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Histone deacetylases: silencers for hire.
Ng HH, Bird A. Ng HH, et al. Trends Biochem Sci. 2000 Mar;25(3):121-6. doi: 10.1016/s0968-0004(00)01551-6. Trends Biochem Sci. 2000. PMID: 10694882 Review.
Ubiquitination of histone H2B by Rad6 is required for efficient Dot1-mediated methylation of histone H3 lysine 79.
Ng HH, Xu RM, Zhang Y, Struhl K. Ng HH, et al. J Biol Chem. 2002 Sep 20;277(38):34655-7. doi: 10.1074/jbc.C200433200. Epub 2002 Aug 6. J Biol Chem. 2002. PMID: 12167634
The Rtf1 component of the Paf1 transcriptional elongation complex is required for ubiquitination of histone H2B.
Ng HH, Dole S, Struhl K. Ng HH, et al. J Biol Chem. 2003 Sep 5;278(36):33625-8. doi: 10.1074/jbc.C300270200. Epub 2003 Jul 21. J Biol Chem. 2003. PMID: 12876293
Targeted recruitment of Set1 histone methylase by elongating Pol II provides a localized mark and memory of recent transcriptional activity.
Ng HH, Robert F, Young RA, Struhl K. Ng HH, et al. Mol Cell. 2003 Mar;11(3):709-19. doi: 10.1016/s1097-2765(03)00092-3. Mol Cell. 2003. PMID: 12667453
Lysine-79 of histone H3 is hypomethylated at silenced loci in yeast and mammalian cells: a potential mechanism for position-effect variegation.
Ng HH, Ciccone DN, Morshead KB, Oettinger MA, Struhl K. Ng HH, et al. Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1820-5. doi: 10.1073/pnas.0437846100. Epub 2003 Feb 6. Proc Natl Acad Sci U S A. 2003. PMID: 12574507 Free PMC article.
Lysine methylation within the globular domain of histone H3 by Dot1 is important for telomeric silencing and Sir protein association.
Ng HH, Feng Q, Wang H, Erdjument-Bromage H, Tempst P, Zhang Y, Struhl K. Ng HH, et al. Genes Dev. 2002 Jun 15;16(12):1518-27. doi: 10.1101/gad.1001502. Genes Dev. 2002. PMID: 12080090 Free PMC article.
DNA methylation and chromatin modification.
Ng HH, Bird A. Ng HH, et al. Curr Opin Genet Dev. 1999 Apr;9(2):158-63. doi: 10.1016/s0959-437x(99)80024-0. Curr Opin Genet Dev. 1999. PMID: 10322130 Review.
Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex.
Nan X, Ng HH, Johnson CA, Laherty CD, Turner BM, Eisenman RN, Bird A. Nan X, et al. Among authors: ng hh. Nature. 1998 May 28;393(6683):386-9. doi: 10.1038/30764. Nature. 1998. PMID: 9620804
Active repression of methylated genes by the chromosomal protein MBD1.
Ng HH, Jeppesen P, Bird A. Ng HH, et al. Mol Cell Biol. 2000 Feb;20(4):1394-406. doi: 10.1128/mcb.20.4.1394-1406.2000. Mol Cell Biol. 2000. PMID: 10648624 Free PMC article.
MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex.
Ng HH, Zhang Y, Hendrich B, Johnson CA, Turner BM, Erdjument-Bromage H, Tempst P, Reinberg D, Bird A. Ng HH, et al. Nat Genet. 1999 Sep;23(1):58-61. doi: 10.1038/12659. Nat Genet. 1999. PMID: 10471499
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