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Interrogating the transcriptome.
Ruan Y, Le Ber P, Ng HH, Liu ET. Ruan Y, et al. Trends Biotechnol. 2004 Jan;22(1):23-30. doi: 10.1016/j.tibtech.2003.11.002. Trends Biotechnol. 2004. PMID: 14690619 No abstract available.
Transcriptional regulation of nanog by OCT4 and SOX2.
Rodda DJ, Chew JL, Lim LH, Loh YH, Wang B, Ng HH, Robson P. Rodda DJ, et al. J Biol Chem. 2005 Jul 1;280(26):24731-7. doi: 10.1074/jbc.M502573200. Epub 2005 Apr 27. J Biol Chem. 2005. PMID: 15860457
Reciprocal transcriptional regulation of Pou5f1 and Sox2 via the Oct4/Sox2 complex in embryonic stem cells.
Chew JL, Loh YH, Zhang W, Chen X, Tam WL, Yeap LS, Li P, Ang YS, Lim B, Robson P, Ng HH. Chew JL, et al. Mol Cell Biol. 2005 Jul;25(14):6031-46. doi: 10.1128/MCB.25.14.6031-6046.2005. Mol Cell Biol. 2005. PMID: 15988017 Free PMC article.
p53 functions as a negative regulator of osteoblastogenesis, osteoblast-dependent osteoclastogenesis, and bone remodeling.
Wang X, Kua HY, Hu Y, Guo K, Zeng Q, Wu Q, Ng HH, Karsenty G, de Crombrugghe B, Yeh J, Li B. Wang X, et al. J Cell Biol. 2006 Jan 2;172(1):115-25. doi: 10.1083/jcb.200507106. Epub 2005 Dec 27. J Cell Biol. 2006. PMID: 16380437 Free PMC article.
A global map of p53 transcription-factor binding sites in the human genome.
Wei CL, Wu Q, Vega VB, Chiu KP, Ng P, Zhang T, Shahab A, Yong HC, Fu Y, Weng Z, Liu J, Zhao XD, Chew JL, Lee YL, Kuznetsov VA, Sung WK, Miller LD, Lim B, Liu ET, Yu Q, Ng HH, Ruan Y. Wei CL, et al. Cell. 2006 Jan 13;124(1):207-19. doi: 10.1016/j.cell.2005.10.043. Cell. 2006. PMID: 16413492
The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells.
Loh YH, Wu Q, Chew JL, Vega VB, Zhang W, Chen X, Bourque G, George J, Leong B, Liu J, Wong KY, Sung KW, Lee CW, Zhao XD, Chiu KP, Lipovich L, Kuznetsov VA, Robson P, Stanton LW, Wei CL, Ruan Y, Lim B, Ng HH. Loh YH, et al. Nat Genet. 2006 Apr;38(4):431-40. doi: 10.1038/ng1760. Epub 2006 Mar 5. Nat Genet. 2006. PMID: 16518401
Sall4 interacts with Nanog and co-occupies Nanog genomic sites in embryonic stem cells.
Wu Q, Chen X, Zhang J, Loh YH, Low TY, Zhang W, Zhang W, Sze SK, Lim B, Ng HH. Wu Q, et al. J Biol Chem. 2006 Aug 25;281(34):24090-4. doi: 10.1074/jbc.C600122200. Epub 2006 Jul 13. J Biol Chem. 2006. PMID: 16840789
Sall4 modulates embryonic stem cell pluripotency and early embryonic development by the transcriptional regulation of Pou5f1.
Zhang J, Tam WL, Tong GQ, Wu Q, Chan HY, Soh BS, Lou Y, Yang J, Ma Y, Chai L, Ng HH, Lufkin T, Robson P, Lim B. Zhang J, et al. Nat Cell Biol. 2006 Oct;8(10):1114-23. doi: 10.1038/ncb1481. Epub 2006 Sep 17. Nat Cell Biol. 2006. PMID: 16980957
Application of advanced technologies in ageing research.
Lim CA, Ng HH. Lim CA, et al. Mech Ageing Dev. 2007 Jan;128(1):149-60. doi: 10.1016/j.mad.2006.11.024. Epub 2006 Nov 17. Mech Ageing Dev. 2007. PMID: 17113130 Review.
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