Ngui J - Search Results

1

Characterization of rat and human UDP-glucuronosyltransferases responsible for the in vitro glucuronidation of diclofenac.

King C, Tang W, Ngui J, Tephly T, Braun M. King C, et al. Among authors: ngui j. Toxicol Sci. 2001 May;61(1):49-53. doi: 10.1093/toxsci/61.1.49. Toxicol Sci. 2001. PMID: 11294973

2

Assessing and minimizing time-dependent inhibition of cytochrome P450 3A in drug discovery: a case study with melanocortin-4 receptor agonists.

Tang W, Stearns RA, Wang RW, Miller RR, Chen Q, Ngui J, Bakshi RK, Nargund RP, Dean DC, Baillie TA. Tang W, et al. Among authors: ngui j. Xenobiotica. 2008 Nov;38(11):1437-51. doi: 10.1080/00498250802464685. Xenobiotica. 2008. PMID: 18841517

3

In vitro bioactivation of dihydrobenzoxathiin selective estrogen receptor modulators by cytochrome P450 3A4 in human liver microsomes: formation of reactive iminium and quinone type metabolites.

Zhang Z, Chen Q, Li Y, Doss GA, Dean BJ, Ngui JS, Silva Elipe M, Kim S, Wu JY, Dininno F, Hammond ML, Stearns RA, Evans DC, Baillie TA, Tang W. Zhang Z, et al. Among authors: ngui js. Chem Res Toxicol. 2005 Apr;18(4):675-85. doi: 10.1021/tx0496789. Chem Res Toxicol. 2005. PMID: 15833027

4

Metabolism of a thiazole benzenesulfonamide derivative, a potent and elective agonist of the human beta3-adrenergic receptor, in rats: identification of a novel isethionic acid conjugate.

Tang W, Stearns RA, Miller RR, Ngui JS, Mathvink RJ, Weber AE, Kwei GY, Strauss JR, Keohane CA, Doss GA, Chiu SH, Baillie TA. Tang W, et al. Among authors: ngui js. Drug Metab Dispos. 2002 Jul;30(7):778-87. doi: 10.1124/dmd.30.7.778. Drug Metab Dispos. 2002. PMID: 12065436

5

Cytochrome P450 3A4-mediated bioactivation of raloxifene: irreversible enzyme inhibition and thiol adduct formation.

Chen Q, Ngui JS, Doss GA, Wang RW, Cai X, DiNinno FP, Blizzard TA, Hammond ML, Stearns RA, Evans DC, Baillie TA, Tang W. Chen Q, et al. Chem Res Toxicol. 2002 Jul;15(7):907-14. doi: 10.1021/tx0200109. Chem Res Toxicol. 2002. PMID: 12119000

6

Influence of different recombinant systems on the cooperativity exhibited by cytochrome P4503A4.

Zhang Z, Li Y, Shou M, Zhang Y, Ngui JS, Stearns RA, Evans DC, Baillie TA, Tang W. Zhang Z, et al. Among authors: ngui js. Xenobiotica. 2004 May;34(5):473-86. doi: 10.1080/00498250410001691271. Xenobiotica. 2004. PMID: 15370963

7

Bioactivation of diclofenac via benzoquinone imine intermediates-identification of urinary mercapturic acid derivatives in rats and humans.

Poon GK, Chen Q, Teffera Y, Ngui JS, Griffin PR, Braun MP, Doss GA, Freeden C, Stearns RA, Evans DC, Baillie TA, Tang W. Poon GK, et al. Among authors: ngui js. Drug Metab Dispos. 2001 Dec;29(12):1608-13. Drug Metab Dispos. 2001. PMID: 11717180

8

Enzyme kinetics of cytochrome P450-mediated reactions.

Shou M, Lin Y, Lu P, Tang C, Mei Q, Cui D, Tang W, Ngui JS, Lin CC, Singh R, Wong BK, Yergey JA, Lin JH, Pearson PG, Baillie TA, Rodrigues AD, Rushmore TH. Shou M, et al. Among authors: ngui js. Curr Drug Metab. 2001 Mar;2(1):17-36. doi: 10.2174/1389200013338784. Curr Drug Metab. 2001. PMID: 11465149 Review.

9

Cytochrome P450 3A4-mediated interaction of diclofenac and quinidine.

Ngui JS, Tang W, Stearns RA, Shou M, Miller RR, Zhang Y, Lin JH, Baillie TA. Ngui JS, et al. Drug Metab Dispos. 2000 Sep;28(9):1043-50. Drug Metab Dispos. 2000. PMID: 10950847

10

In vitro stimulation of warfarin metabolism by quinidine: increases in the formation of 4'- and 10-hydroxywarfarin.

Ngui JS, Chen Q, Shou M, Wang RW, Stearns RA, Baillie TA, Tang W. Ngui JS, et al. Drug Metab Dispos. 2001 Jun;29(6):877-86. Drug Metab Dispos. 2001. PMID: 11353757

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