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Clinical blockade of PD1 and LAG3--potential mechanisms of action.
Nguyen LT, Ohashi PS. Nguyen LT, et al. Nat Rev Immunol. 2015 Jan;15(1):45-56. doi: 10.1038/nri3790. Nat Rev Immunol. 2015. PMID: 25534622 Review.
Tumor growth enhances cross-presentation leading to limited T cell activation without tolerance.
Nguyen LT, Elford AR, Murakami K, Garza KM, Schoenberger SP, Odermatt B, Speiser DE, Ohashi PS. Nguyen LT, et al. J Exp Med. 2002 Feb 18;195(4):423-35. doi: 10.1084/jem.20010032. J Exp Med. 2002. PMID: 11854356 Free PMC article.
TCR affinity and negative regulation limit autoimmunity.
Gronski MA, Boulter JM, Moskophidis D, Nguyen LT, Holmberg K, Elford AR, Deenick EK, Kim HO, Penninger JM, Odermatt B, Gallimore A, Gascoigne NR, Ohashi PS. Gronski MA, et al. Nat Med. 2004 Nov;10(11):1234-9. doi: 10.1038/nm1114. Epub 2004 Oct 3. Nat Med. 2004. PMID: 15467726
Adjuvant IL-7 antagonizes multiple cellular and molecular inhibitory networks to enhance immunotherapies.
Pellegrini M, Calzascia T, Elford AR, Shahinian A, Lin AE, Dissanayake D, Dhanji S, Nguyen LT, Gronski MA, Morre M, Assouline B, Lahl K, Sparwasser T, Ohashi PS, Mak TW. Pellegrini M, et al. Nat Med. 2009 May;15(5):528-36. doi: 10.1038/nm.1953. Epub 2009 Apr 26. Nat Med. 2009. PMID: 19396174
Mobilizing and evaluating anticancer T cells: pitfalls and solutions.
Robert-Tissot C, Nguyen LT, Ohashi PS, Speiser DE. Robert-Tissot C, et al. Expert Rev Vaccines. 2013 Nov;12(11):1325-40. doi: 10.1586/14760584.2013.843456. Epub 2013 Oct 16. Expert Rev Vaccines. 2013. PMID: 24127850 Review.
A distinct innate lymphoid cell population regulates tumor-associated T cells.
Crome SQ, Nguyen LT, Lopez-Verges S, Yang SY, Martin B, Yam JY, Johnson DJ, Nie J, Pniak M, Yen PH, Milea A, Sowamber R, Katz SR, Bernardini MQ, Clarke BA, Shaw PA, Lang PA, Berman HK, Pugh TJ, Lanier LL, Ohashi PS. Crome SQ, et al. Nat Med. 2017 Mar;23(3):368-375. doi: 10.1038/nm.4278. Epub 2017 Feb 6. Nat Med. 2017. PMID: 28165478 Free PMC article.
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