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Inflammasome Adaptor ASC Suppresses Apoptosis of Gastric Cancer Cells by an IL18-Mediated Inflammation-Independent Mechanism.
Deswaerte V, Nguyen P, West A, Browning AF, Yu L, Ruwanpura SM, Balic J, Livis T, Girard C, Preaudet A, Oshima H, Fung KY, Tye H, Najdovska M, Ernst M, Oshima M, Gabay C, Putoczki T, Jenkins BJ. Deswaerte V, et al. Among authors: nguyen p. Cancer Res. 2018 Mar 1;78(5):1293-1307. doi: 10.1158/0008-5472.CAN-17-1887. Epub 2017 Dec 27. Cancer Res. 2018. PMID: 29282220
Interleukin-11 is the dominant IL-6 family cytokine during gastrointestinal tumorigenesis and can be targeted therapeutically.
Putoczki TL, Thiem S, Loving A, Busuttil RA, Wilson NJ, Ziegler PK, Nguyen PM, Preaudet A, Farid R, Edwards KM, Boglev Y, Luwor RB, Jarnicki A, Horst D, Boussioutas A, Heath JK, Sieber OM, Pleines I, Kile BT, Nash A, Greten FR, McKenzie BS, Ernst M. Putoczki TL, et al. Cancer Cell. 2013 Aug 12;24(2):257-71. doi: 10.1016/j.ccr.2013.06.017. Cancer Cell. 2013. PMID: 23948300 Free article.
Stomach-Specific Activation of Oncogenic KRAS and STAT3-Dependent Inflammation Cooperatively Promote Gastric Tumorigenesis in a Preclinical Model.
Thiem S, Eissmann MF, Elzer J, Jonas A, Putoczki TL, Poh A, Nguyen P, Preaudet A, Flanagan D, Vincan E, Waring P, Buchert M, Jarnicki A, Ernst M. Thiem S, et al. Among authors: nguyen p. Cancer Res. 2016 Apr 15;76(8):2277-87. doi: 10.1158/0008-5472.CAN-15-3089. Epub 2016 Feb 2. Cancer Res. 2016. PMID: 26837764
ADAM17 is required for EGF-R-induced intestinal tumors via IL-6 trans-signaling.
Schmidt S, Schumacher N, Schwarz J, Tangermann S, Kenner L, Schlederer M, Sibilia M, Linder M, Altendorf-Hofmann A, Knösel T, Gruber ES, Oberhuber G, Bolik J, Rehman A, Sinha A, Lokau J, Arnold P, Cabron AS, Zunke F, Becker-Pauly C, Preaudet A, Nguyen P, Huynh J, Afshar-Sterle S, Chand AL, Westermann J, Dempsey PJ, Garbers C, Schmidt-Arras D, Rosenstiel P, Putoczki T, Ernst M, Rose-John S. Schmidt S, et al. Among authors: nguyen p. J Exp Med. 2018 Apr 2;215(4):1205-1225. doi: 10.1084/jem.20171696. Epub 2018 Feb 22. J Exp Med. 2018. PMID: 29472497 Free PMC article.
Emerging roles for Interleukin-11 in disease.
Nguyen PM, Abdirahman SM, Putoczki TL. Nguyen PM, et al. Growth Factors. 2019 Apr;37(1-2):1-11. doi: 10.1080/08977194.2019.1620227. Epub 2019 Jun 4. Growth Factors. 2019. PMID: 31161823 Review.
4,307 results