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An intranasal ASO therapeutic targeting SARS-CoV-2.
Zhu C, Lee JY, Woo JZ, Xu L, Nguyenla X, Yamashiro LH, Ji F, Biering SB, Van Dis E, Gonzalez F, Fox D, Wehri E, Rustagi A, Pinsky BA, Schaletzky J, Blish CA, Chiu C, Harris E, Sadreyev RI, Stanley S, Kauppinen S, Rouskin S, Näär AM. Zhu C, et al. Among authors: nguyenla x. Nat Commun. 2022 Aug 3;13(1):4503. doi: 10.1038/s41467-022-32216-0. Nat Commun. 2022. PMID: 35922434 Free PMC article.
Screening a Library of FDA-Approved and Bioactive Compounds for Antiviral Activity against SARS-CoV-2.
Biering SB, Van Dis E, Wehri E, Yamashiro LH, Nguyenla X, Dugast-Darzacq C, Graham TGW, Stroumza JR, Golovkine GR, Roberts AW, Fines DM, Spradlin JN, Ward CC, Bajaj T, Dovala D, Schulze-Gamen U, Bajaj R, Fox DM, Ott M, Murthy N, Nomura DK, Schaletzky J, Stanley SA. Biering SB, et al. Among authors: nguyenla x. ACS Infect Dis. 2021 Aug 13;7(8):2337-2351. doi: 10.1021/acsinfecdis.1c00017. Epub 2021 Jun 15. ACS Infect Dis. 2021. PMID: 34129317
SARS-CoV-2 nucleocapsid protein forms condensates with viral genomic RNA.
Jack A, Ferro LS, Trnka MJ, Wehri E, Nadgir A, Nguyenla X, Fox D, Costa K, Stanley S, Schaletzky J, Yildiz A. Jack A, et al. Among authors: nguyenla x. PLoS Biol. 2021 Oct 11;19(10):e3001425. doi: 10.1371/journal.pbio.3001425. eCollection 2021 Oct. PLoS Biol. 2021. PMID: 34634033 Free PMC article.
Genome-wide bidirectional CRISPR screens identify mucins as host factors modulating SARS-CoV-2 infection.
Biering SB, Sarnik SA, Wang E, Zengel JR, Leist SR, Schäfer A, Sathyan V, Hawkins P, Okuda K, Tau C, Jangid AR, Duffy CV, Wei J, Gilmore RC, Alfajaro MM, Strine MS, Nguyenla X, Van Dis E, Catamura C, Yamashiro LH, Belk JA, Begeman A, Stark JC, Shon DJ, Fox DM, Ezzatpour S, Huang E, Olegario N, Rustagi A, Volmer AS, Livraghi-Butrico A, Wehri E, Behringer RR, Cheon DJ, Schaletzky J, Aguilar HC, Puschnik AS, Button B, Pinsky BA, Blish CA, Baric RS, O'Neal WK, Bertozzi CR, Wilen CB, Boucher RC, Carette JE, Stanley SA, Harris E, Konermann S, Hsu PD. Biering SB, et al. Among authors: nguyenla x. Nat Genet. 2022 Aug;54(8):1078-1089. doi: 10.1038/s41588-022-01131-x. Epub 2022 Jul 25. Nat Genet. 2022. PMID: 35879412 Free PMC article.
Broad-spectrum CRISPR-mediated inhibition of SARS-CoV-2 variants and endemic coronaviruses in vitro.
Zeng L, Liu Y, Nguyenla XH, Abbott TR, Han M, Zhu Y, Chemparathy A, Lin X, Chen X, Wang H, Rane DA, Spatz JM, Jain S, Rustagi A, Pinsky B, Zepeda AE, Kadina AP, Walker JA 3rd, Holden K, Temperton N, Cochran JR, Barron AE, Connolly MD, Blish CA, Lewis DB, Stanley SA, La Russa MF, Qi LS. Zeng L, et al. Among authors: nguyenla xh. Nat Commun. 2022 May 19;13(1):2766. doi: 10.1038/s41467-022-30546-7. Nat Commun. 2022. PMID: 35589813 Free PMC article.
Open-source RNA extraction and RT-qPCR methods for SARS-CoV-2 detection.
Graham TGW, Dugast-Darzacq C, Dailey GM, Nguyenla XH, Van Dis E, Esbin MN, Abidi A, Stanley SA, Darzacq X, Tjian R. Graham TGW, et al. Among authors: nguyenla xh. PLoS One. 2021 Feb 3;16(2):e0246647. doi: 10.1371/journal.pone.0246647. eCollection 2021. PLoS One. 2021. PMID: 33534838 Free PMC article.
Mucosal Vaccination with Cyclic Dinucleotide Adjuvants Induces Effective T Cell Homing and IL-17-Dependent Protection against Mycobacterium tuberculosis Infection.
Jong RM, Van Dis E, Berry SB, Nguyenla X, Baltodano A, Pastenkos G, Xu C, Fox D, Yosef N, McWhirter SM, Stanley SA. Jong RM, et al. Among authors: nguyenla x. J Immunol. 2022 Jan 15;208(2):407-419. doi: 10.4049/jimmunol.2100029. Epub 2021 Dec 29. J Immunol. 2022. PMID: 34965963 Free PMC article.
ESAT-6 undergoes self-association at phagosomal pH and an ESAT-6 specific nanobody restricts M. tuberculosis growth in macrophages.
Bates TA, Trank-Greene M, Nguyenla X, Anastas A, Gurmessa SK, Merutka IR, Dixon SD, Shumate A, Groncki AR, Parson MA, Ingram JR, Barklis E, Burke JE, Shinde U, Ploegh HL, Tafesse FG. Bates TA, et al. Among authors: nguyenla x. bioRxiv [Preprint]. 2024 Mar 19:2023.08.16.553641. doi: 10.1101/2023.08.16.553641. bioRxiv. 2024. PMID: 37645775 Free PMC article. Preprint.
Discovery of SARS-CoV-2 antiviral synergy between remdesivir and approved drugs in human lung cells.
Nguyenla X, Wehri E, Van Dis E, Biering SB, Yamashiro LH, Zhu C, Stroumza J, Dugast-Darzacq C, Graham TGW, Wang X, Jockusch S, Tao C, Chien M, Xie W, Patel DJ, Meyer C, Garzia A, Tuschl T, Russo JJ, Ju J, Näär AM, Stanley S, Schaletzky J. Nguyenla X, et al. Sci Rep. 2022 Nov 2;12(1):18506. doi: 10.1038/s41598-022-21034-5. Sci Rep. 2022. PMID: 36323770 Free PMC article.
11 results