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Gut microbiota and intestinal FXR mediate the clinical benefits of metformin.

Sun L, Xie C, Wang G, Wu Y, Wu Q, Wang X, Liu J, Deng Y, Xia J, Chen B, Zhang S, Yun C, Lian G, Zhang X, Zhang H, Bisson WH, Shi J, Gao X, Ge P, Liu C, Krausz KW, Nichols RG, Cai J, Rimal B, Patterson AD, Wang X, Gonzalez FJ, Jiang C. Sun L, et al. Among authors: nichols rg. Nat Med. 2018 Dec;24(12):1919-1929. doi: 10.1038/s41591-018-0222-4. Epub 2018 Nov 5. Nat Med. 2018. PMID: 30397356 Free PMC article.

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Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the Gut Microbiota.

Li G, Xie C, Lu S, Nichols RG, Tian Y, Li L, Patel D, Ma Y, Brocker CN, Yan T, Krausz KW, Xiang R, Gavrilova O, Patterson AD, Gonzalez FJ. Li G, et al. Among authors: nichols rg. Cell Metab. 2017 Oct 3;26(4):672-685.e4. doi: 10.1016/j.cmet.2017.08.019. Epub 2017 Sep 14. Cell Metab. 2017. PMID: 28918936 Free PMC article.

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Interplay Between the Host, the Human Microbiome, and Drug Metabolism.

Nichols RG, Peters JM, Patterson AD. Nichols RG, et al. Hum Genomics. 2019 Jun 11;13(1):27. doi: 10.1186/s40246-019-0211-9. Hum Genomics. 2019. PMID: 31186074 Free PMC article. Review.

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Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease.

Jiang C, Xie C, Li F, Zhang L, Nichols RG, Krausz KW, Cai J, Qi Y, Fang ZZ, Takahashi S, Tanaka N, Desai D, Amin SG, Albert I, Patterson AD, Gonzalez FJ. Jiang C, et al. Among authors: nichols rg. J Clin Invest. 2015 Jan;125(1):386-402. doi: 10.1172/JCI76738. Epub 2014 Dec 15. J Clin Invest. 2015. PMID: 25500885 Free PMC article.

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Intestine farnesoid X receptor agonist and the gut microbiota activate G-protein bile acid receptor-1 signaling to improve metabolism.

Pathak P, Xie C, Nichols RG, Ferrell JM, Boehme S, Krausz KW, Patterson AD, Gonzalez FJ, Chiang JYL. Pathak P, et al. Among authors: nichols rg. Hepatology. 2018 Oct;68(4):1574-1588. doi: 10.1002/hep.29857. Epub 2018 May 21. Hepatology. 2018. PMID: 29486523 Free PMC article.

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The microbiome modulating activity of bile acids.

Tian Y, Gui W, Koo I, Smith PB, Allman EL, Nichols RG, Rimal B, Cai J, Liu Q, Patterson AD. Tian Y, et al. Among authors: nichols rg. Gut Microbes. 2020 Jul 3;11(4):979-996. doi: 10.1080/19490976.2020.1732268. Epub 2020 Mar 5. Gut Microbes. 2020. PMID: 32138583 Free PMC article.

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Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the Gut Microbiota.

Li G, Xie C, Lu S, Nichols RG, Tian Y, Li L, Patel D, Ma Y, Brocker CN, Yan T, Krausz KW, Xiang R, Gavrilova O, Patterson AD, Gonzalez FJ. Li G, et al. Among authors: nichols rg. Cell Metab. 2017 Nov 7;26(5):801. doi: 10.1016/j.cmet.2017.10.007. Cell Metab. 2017. PMID: 29117546 Free PMC article. No abstract available.

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The relationship between the gut microbiome and host gene expression: a review.

Nichols RG, Davenport ER. Nichols RG, et al. Hum Genet. 2020 Nov 22:1-14. doi: 10.1007/s00439-020-02237-0. Online ahead of print. Hum Genet. 2020. PMID: 33221945 Free PMC article. Review.

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Metabolic impact of persistent organic pollutants on gut microbiota.

Tian Y, Gui W, Rimal B, Koo I, Smith PB, Nichols RG, Cai J, Liu Q, Patterson AD. Tian Y, et al. Among authors: nichols rg. Gut Microbes. 2020 Nov 9;12(1):1-16. doi: 10.1080/19490976.2020.1848209. Gut Microbes. 2020. PMID: 33295235 Free PMC article.

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Perfluorooctane sulfonate alters gut microbiota-host metabolic homeostasis in mice.

Zhang L, Rimal B, Nichols RG, Tian Y, Smith PB, Hatzakis E, Chang SC, Butenhoff JL, Peters JM, Patterson AD. Zhang L, et al. Among authors: nichols rg. Toxicology. 2020 Feb 15;431:152365. doi: 10.1016/j.tox.2020.152365. Epub 2020 Jan 8. Toxicology. 2020. PMID: 31926186 Free PMC article.

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