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Alix, a novel mouse protein undergoing calcium-dependent interaction with the apoptosis-linked-gene 2 (ALG-2) protein.
Missotten M, Nichols A, Rieger K, Sadoul R. Missotten M, et al. Among authors: nichols a. Cell Death Differ. 1999 Feb;6(2):124-9. doi: 10.1038/sj.cdd.4400456. Cell Death Differ. 1999. PMID: 10200558
Here we have used ALG-2 as bait in a yeast two hybrid screen of a mouse brain cDNA library. We found that ALG-2 binds to itself and to a novel protein that we call ALG-2 interacting protein X, Alix. ...Alix is a potential regulator or downstream effect …
Here we have used ALG-2 as bait in a yeast two hybrid screen of a mouse brain cDNA library. We found that ALG-2 binds to itsel …
The DRY motif as a molecular switch of the human oxytocin receptor.
Favre N, Fanelli F, Missotten M, Nichols A, Wilson J, di Tiani M, Rommel C, Scheer A. Favre N, et al. Among authors: nichols a. Biochemistry. 2005 Aug 2;44(30):9990-10008. doi: 10.1021/bi0509853. Biochemistry. 2005. PMID: 16042376
A single-amino acid substitution within the highly conserved E/DRY motif at the cytosolic extension of helix 3 [i.e., D136(3.49)N] increased the rate of both basal and agonist-stimulated inositol phosphate (IP(3)) accumulation of the receptor. Furthermore, like for a
A single-amino acid substitution within the highly conserved E/DRY motif at the cytosolic extension of helix 3 [i.e., D136(3.49)N] in
MAP kinase phosphatase 3 (MKP3) interacts with and is phosphorylated by protein kinase CK2alpha.
Castelli M, Camps M, Gillieron C, Leroy D, Arkinstall S, Rommel C, Nichols A. Castelli M, et al. Among authors: nichols a. J Biol Chem. 2004 Oct 22;279(43):44731-9. doi: 10.1074/jbc.M407669200. Epub 2004 Jul 28. J Biol Chem. 2004. PMID: 15284227
Mitogen-activated protein (MAP) kinases play a central role in controlling a wide range of cellular functions following their activation by a variety of extracellular stimuli. ...Although ERK2 activity is regulated by its phosphorylation state, MKP3 is regula …
Mitogen-activated protein (MAP) kinases play a central role in controlling a wide range of cellular functions following their …
Substrate recognition domains within extracellular signal-regulated kinase mediate binding and catalytic activation of mitogen-activated protein kinase phosphatase-3.
Nichols A, Camps M, Gillieron C, Chabert C, Brunet A, Wilsbacher J, Cobb M, Pouyssegur J, Shaw JP, Arkinstall S. Nichols A, et al. J Biol Chem. 2000 Aug 11;275(32):24613-21. doi: 10.1074/jbc.M001515200. J Biol Chem. 2000. PMID: 10811804
Mitogen-activated protein (MAP) kinase phosphatase-3 (MKP-3) is a dual specificity phosphatase that inactivates extracellular signal-regulated kinase (ERK) MAP kinases. ...We have used a series of p38/ERK chimeric molecules to identify domains within ERK necessary f …
Mitogen-activated protein (MAP) kinase phosphatase-3 (MKP-3) is a dual specificity phosphatase that inactivates extracellular signal- …
Dual specificity phosphatases: a gene family for control of MAP kinase function.
Camps M, Nichols A, Arkinstall S. Camps M, et al. Among authors: nichols a. FASEB J. 2000 Jan;14(1):6-16. FASEB J. 2000. PMID: 10627275 Review.
Mitogen-activated protein (MAP) kinases are important players in signal transduction pathways activated by a range of stimuli and mediate a number of physiological and pathological changes in cell function. MAP kinase activation requires phosphorylation on a
Mitogen-activated protein (MAP) kinases are important players in signal transduction pathways activated by a range of stimuli and med …
Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis.
Desagher S, Osen-Sand A, Nichols A, Eskes R, Montessuit S, Lauper S, Maundrell K, Antonsson B, Martinou JC. Desagher S, et al. Among authors: nichols a. J Cell Biol. 1999 Mar 8;144(5):891-901. doi: 10.1083/jcb.144.5.891. J Cell Biol. 1999. PMID: 10085289 Free PMC article.
Here we report that in staurosporine-induced apoptosis of HeLa cells, Bid, a BH3 domain containing protein, translocates from the cytosol to mitochondria. ...Using isolated mitochondria and various BH3 mutants of Bid, we demonstrate that direct binding of Bid to Bax is …
Here we report that in staurosporine-induced apoptosis of HeLa cells, Bid, a BH3 domain containing protein, translocates from the cyt …
Catalytic activation of the phosphatase MKP-3 by ERK2 mitogen-activated protein kinase.
Camps M, Nichols A, Gillieron C, Antonsson B, Muda M, Chabert C, Boschert U, Arkinstall S. Camps M, et al. Among authors: nichols a. Science. 1998 May 22;280(5367):1262-5. doi: 10.1126/science.280.5367.1262. Science. 1998. PMID: 9596579
Catalytic activation of MAP kinase phosphatases through substrate binding may regulate MAP kinase activation by a large number of receptor systems....
Catalytic activation of MAP kinase phosphatases through substrate binding may regulate MAP kinase activation by a large number of rec …
Bax-induced cytochrome C release from mitochondria is independent of the permeability transition pore but highly dependent on Mg2+ ions.
Eskes R, Antonsson B, Osen-Sand A, Montessuit S, Richter C, Sadoul R, Mazzei G, Nichols A, Martinou JC. Eskes R, et al. Among authors: nichols a. J Cell Biol. 1998 Oct 5;143(1):217-24. doi: 10.1083/jcb.143.1.217. J Cell Biol. 1998. PMID: 9763433 Free PMC article.
Bax, a death-promoting member, is a pore-forming, mitochondria-associated protein whose mechanism of action is still unknown. ...The release of cytochrome C has been postulated to be a consequence of the opening of the mitochondrial permeability transition po …
Bax, a death-promoting member, is a pore-forming, mitochondria-associated protein whose mechanism of action is still unknown. …
The p75 neurotrophin receptor: effects on neuron survival in vitro and interaction with death domain-containing adaptor proteins.
Nichols A, Martinou I, Maundrell K, Martinou JC. Nichols A, et al. Apoptosis. 1998 Sep;3(4):289-94. doi: 10.1023/a:1009617426753. Apoptosis. 1998. PMID: 14646493
The p75 neurotrophin receptor (p75NTR) is a death domain (DD) containing receptor of the TNF/FAS(APO-1) family. p75NTR has recently been shown to mediate apoptosis in certain types of neurons as well as in oligodendrocytes. ...
The p75 neurotrophin receptor (p75NTR) is a death domain (DD) containing receptor of the TNF/FAS(APO-1) family. p75NTR has recently b …
Design, synthesis, and biological activity of novel, potent, and selective (benzoylaminomethyl)thiophene sulfonamide inhibitors of c-Jun-N-terminal kinase.
Rückle T, Biamonte M, Grippi-Vallotton T, Arkinstall S, Cambet Y, Camps M, Chabert C, Church DJ, Halazy S, Jiang X, Martinou I, Nichols A, Sauer W, Gotteland JP. Rückle T, et al. Among authors: nichols a. J Med Chem. 2004 Dec 30;47(27):6921-34. doi: 10.1021/jm031112e. J Med Chem. 2004. PMID: 15615541
Several lines of evidence support the hypothesis that c-Jun N-terminal kinases (JNKs) play a critical role in a wide range of disease states including cell death (apoptosis)-related and inflammatory disorders (epilepsy, brain, heart and renal ischemia, neurodegenera …
Several lines of evidence support the hypothesis that c-Jun N-terminal kinases (JNKs) play a critical role in a wide range of …
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