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Targeting Glycolysis in Alloreactive T Cells to Prevent Acute Graft-Versus-Host Disease While Preserving Graft-Versus-Leukemia Effect.
Huang Y, Zou Y, Jiao Y, Shi P, Nie X, Huang W, Xiong C, Choi M, Huang C, Macintyre AN, Nichols A, Li F, Li CY, MacIver NJ, Cardona DM, Brennan TV, Li Z, Chao NJ, Rathmell JC, Chen BJ. Huang Y, et al. Front Immunol. 2022 Feb 28;13:751296. doi: 10.3389/fimmu.2022.751296. eCollection 2022. Front Immunol. 2022. PMID: 35296079 Free PMC article.
Estrogen-related receptor-α is a metabolic regulator of effector T-cell activation and differentiation.
Michalek RD, Gerriets VA, Nichols AG, Inoue M, Kazmin D, Chang CY, Dwyer MA, Nelson ER, Pollizzi KN, Ilkayeva O, Giguere V, Zuercher WJ, Powell JD, Shinohara ML, McDonnell DP, Rathmell JC. Michalek RD, et al. Among authors: nichols ag. Proc Natl Acad Sci U S A. 2011 Nov 8;108(45):18348-53. doi: 10.1073/pnas.1108856108. Epub 2011 Oct 31. Proc Natl Acad Sci U S A. 2011. PMID: 22042850 Free PMC article.
AMPK Is Essential to Balance Glycolysis and Mitochondrial Metabolism to Control T-ALL Cell Stress and Survival.
Kishton RJ, Barnes CE, Nichols AG, Cohen S, Gerriets VA, Siska PJ, Macintyre AN, Goraksha-Hicks P, de Cubas AA, Liu T, Warmoes MO, Abel ED, Yeoh AE, Gershon TR, Rathmell WK, Richards KL, Locasale JW, Rathmell JC. Kishton RJ, et al. Among authors: nichols ag. Cell Metab. 2016 Apr 12;23(4):649-62. doi: 10.1016/j.cmet.2016.03.008. Cell Metab. 2016. PMID: 27076078 Free PMC article.
Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation.
Gerriets VA, Kishton RJ, Nichols AG, Macintyre AN, Inoue M, Ilkayeva O, Winter PS, Liu X, Priyadharshini B, Slawinska ME, Haeberli L, Huck C, Turka LA, Wood KC, Hale LP, Smith PA, Schneider MA, MacIver NJ, Locasale JW, Newgard CB, Shinohara ML, Rathmell JC. Gerriets VA, et al. Among authors: nichols ag. J Clin Invest. 2015 Jan;125(1):194-207. doi: 10.1172/JCI76012. Epub 2014 Dec 1. J Clin Invest. 2015. PMID: 25437876 Free PMC article.
29 results