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Pharmacokinetics of sildenafil after single oral doses in healthy male subjects: absolute bioavailability, food effects and dose proportionality.
Nichols DJ, Muirhead GJ, Harness JA. Nichols DJ, et al. Br J Clin Pharmacol. 2002;53 Suppl 1(Suppl 1):5S-12S. doi: 10.1046/j.0306-5251.2001.00027.x. Br J Clin Pharmacol. 2002. PMID: 11879254 Free PMC article. Clinical Trial.
Model-based drug development: a rational approach to efficiently accelerate drug development.
Milligan PA, Brown MJ, Marchant B, Martin SW, van der Graaf PH, Benson N, Nucci G, Nichols DJ, Boyd RA, Mandema JW, Krishnaswami S, Zwillich S, Gruben D, Anziano RJ, Stock TC, Lalonde RL. Milligan PA, et al. Among authors: nichols dj. Clin Pharmacol Ther. 2013 Jun;93(6):502-14. doi: 10.1038/clpt.2013.54. Epub 2013 Mar 14. Clin Pharmacol Ther. 2013. PMID: 23588322
Evaluation of the Intelisite capsule to deliver theophylline and frusemide tablets to the small intestine and colon.
Clear NJ, Milton A, Humphrey M, Henry BT, Wulff M, Nichols DJ, Anziano RJ, Wilding I. Clear NJ, et al. Among authors: nichols dj. Eur J Pharm Sci. 2001 Jul;13(4):375-84. doi: 10.1016/s0928-0987(01)00134-8. Eur J Pharm Sci. 2001. PMID: 11408152 Clinical Trial.
Pharmacokinetics and metabolism of darifenacin in the mouse, rat, dog and man.
Beaumont KC, Cussans NJ, Nichols DJ, Smith DA. Beaumont KC, et al. Among authors: nichols dj. Xenobiotica. 1998 Jan;28(1):63-75. doi: 10.1080/004982598239768. Xenobiotica. 1998. PMID: 9493320
The pharmacokinetics and pharmacodynamics of oral dofetilide after twice daily and three times daily dosing.
Allen MJ, Nichols DJ, Oliver SD. Allen MJ, et al. Among authors: nichols dj. Br J Clin Pharmacol. 2000 Sep;50(3):247-53. doi: 10.1046/j.1365-2125.2000.00243.x. Br J Clin Pharmacol. 2000. PMID: 10971309 Free PMC article. Clinical Trial.
Pharmacokinetics of trospectomycin sulphate in healthy subjects after single intravenous and intramuscular doses.
Nichols DJ, Bye A, Novak E. Nichols DJ, et al. Br J Clin Pharmacol. 1991 Aug;32(2):255-7. doi: 10.1111/j.1365-2125.1991.tb03893.x. Br J Clin Pharmacol. 1991. PMID: 1834145 Free PMC article.
Effect of dofetilide on the pharmacokinetics of digoxin.
Kleinermans D, Nichols DJ, Dalrymple I. Kleinermans D, et al. Among authors: nichols dj. Am J Cardiol. 2001 Jan 15;87(2):248-50, A9-10. doi: 10.1016/s0002-9149(00)01332-1. Am J Cardiol. 2001. PMID: 11152855 Clinical Trial.
Effect of cimetidine and ranitidine on pharmacokinetics and pharmacodynamics of a single dose of dofetilide.
Abel S, Nichols DJ, Brearley CJ, Eve MD. Abel S, et al. Among authors: nichols dj. Br J Clin Pharmacol. 2000 Jan;49(1):64-71. doi: 10.1046/j.1365-2125.2000.00114.x. Br J Clin Pharmacol. 2000. PMID: 10606839 Free PMC article. Clinical Trial.
Effect of omeprazole on the steady-state pharmacokinetics of voriconazole.
Wood N, Tan K, Purkins L, Layton G, Hamlin J, Kleinermans D, Nichols D. Wood N, et al. Among authors: nichols d. Br J Clin Pharmacol. 2003 Dec;56 Suppl 1(Suppl 1):56-61. doi: 10.1046/j.1365-2125.2003.02000.x. Br J Clin Pharmacol. 2003. PMID: 14616415 Free PMC article. Clinical Trial.
Histamine H2-receptor antagonists have no clinically significant effect on the steady-state pharmacokinetics of voriconazole.
Purkins L, Wood N, Kleinermans D, Nichols D. Purkins L, et al. Among authors: nichols d. Br J Clin Pharmacol. 2003 Dec;56 Suppl 1(Suppl 1):51-5. doi: 10.1046/j.1365-2125.2003.01999.x. Br J Clin Pharmacol. 2003. PMID: 14616414 Free PMC article. Clinical Trial.
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