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From bench to clinic with apoptosis-based therapeutic agents.
Nicholson DW. Nicholson DW. Nature. 2000 Oct 12;407(6805):810-6. doi: 10.1038/35037747. Nature. 2000. PMID: 11048733 Review.
Apoptosis and caspases regulate death and inflammation in sepsis.
Hotchkiss RS, Nicholson DW. Hotchkiss RS, et al. Nat Rev Immunol. 2006 Nov;6(11):813-22. doi: 10.1038/nri1943. Epub 2006 Oct 13. Nat Rev Immunol. 2006. PMID: 17039247 Review.
Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome.
Marsden VS, O'Connor L, O'Reilly LA, Silke J, Metcalf D, Ekert PG, Huang DC, Cecconi F, Kuida K, Tomaselli KJ, Roy S, Nicholson DW, Vaux DL, Bouillet P, Adams JM, Strasser A. Marsden VS, et al. Nature. 2002 Oct 10;419(6907):634-7. doi: 10.1038/nature01101. Epub 2002 Sep 25. Nature. 2002. PMID: 12374983
Apoptosis. Baiting death inhibitors.
Nicholson DW. Nicholson DW. Nature. 2001 Mar 1;410(6824):33-4. doi: 10.1038/35065201. Nature. 2001. PMID: 11242030 No abstract available.
Neuroprotection by the inhibition of apoptosis.
Robertson GS, Crocker SJ, Nicholson DW, Schulz JB. Robertson GS, et al. Brain Pathol. 2000 Apr;10(2):283-92. doi: 10.1111/j.1750-3639.2000.tb00262.x. Brain Pathol. 2000. PMID: 10764048 Review.
Control of apoptosis by proteases.
Thornberry NA, Rosen A, Nicholson DW. Thornberry NA, et al. Adv Pharmacol. 1997;41:155-77. doi: 10.1016/s1054-3589(08)61058-3. Adv Pharmacol. 1997. PMID: 9204145 Review. No abstract available.
Deficiency in caspase-9 or caspase-3 induces compensatory caspase activation.
Zheng TS, Hunot S, Kuida K, Momoi T, Srinivasan A, Nicholson DW, Lazebnik Y, Flavell RA. Zheng TS, et al. Nat Med. 2000 Nov;6(11):1241-7. doi: 10.1038/81343. Nat Med. 2000. PMID: 11062535
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