Nicolas CT - Search Results

1

Curative Ex Vivo Hepatocyte-Directed Gene Editing in a Mouse Model of Hereditary Tyrosinemia Type 1.

VanLith C, Guthman R, Nicolas CT, Allen K, Du Z, Joo DJ, Nyberg SL, Lillegard JB, Hickey RD. VanLith C, et al. Among authors: nicolas ct. Hum Gene Ther. 2018 Nov;29(11):1315-1326. doi: 10.1089/hum.2017.252. Epub 2018 Jun 22. Hum Gene Ther. 2018. PMID: 29764210 Free PMC article.

2

Hepatotoxicity and Toxicology of In Vivo Lentiviral Vector Administration in Healthy and Liver-Injury Mouse Models.

Kaiser RA, Nicolas CT, Allen KL, Chilton JA, Du Z, Hickey RD, Lillegard JB. Kaiser RA, et al. Among authors: nicolas ct. Hum Gene Ther Clin Dev. 2019 Jun;30(2):57-66. doi: 10.1089/humc.2018.249. Epub 2019 Apr 11. Hum Gene Ther Clin Dev. 2019. PMID: 30860398 Free PMC article.

3

Hepatocyte spheroids as an alternative to single cells for transplantation after ex vivo gene therapy in mice and pig models.

Nicolas CT, Hickey RD, Allen KL, Du Z, Guthman RM, Kaiser RA, Amiot B, Bansal A, Pandey MK, Suksanpaisan L, DeGrado TR, Nyberg SL, Lillegard JB. Nicolas CT, et al. Surgery. 2018 Sep;164(3):473-481. doi: 10.1016/j.surg.2018.04.012. Epub 2018 Jun 6. Surgery. 2018. PMID: 29884476 Free PMC article.

4

Lentiviral Vector-mediated Gene Therapy of Hepatocytes Ex Vivo for Autologous Transplantation in Swine.

Kaiser RA, Mao SA, Glorioso J, Amiot B, Nicolas CT, Allen KL, Du Z, VanLith CJ, Hickey RD, Nyberg SL, Lillegard JB. Kaiser RA, et al. Among authors: nicolas ct. J Vis Exp. 2018 Nov 4;(141):10.3791/58399. doi: 10.3791/58399. J Vis Exp. 2018. PMID: 30451238 Free PMC article.

5

Autologous Gene and Cell Therapy Provides Safe and Long-Term Curative Therapy in A Large Pig Model of Hereditary Tyrosinemia Type 1.

Hickey RD, Nicolas CT, Allen K, Mao S, Elgilani F, Glorioso J, Amiot B, VanLith C, Guthman R, Du Z, Chen H, Harding CO, Kaiser RA, Nyberg SL, Lillegard JB. Hickey RD, et al. Among authors: nicolas ct. Cell Transplant. 2019 Jan;28(1):79-88. doi: 10.1177/0963689718814188. Epub 2018 Nov 26. Cell Transplant. 2019. PMID: 30477316 Free PMC article.

6

Ex Vivo Hepatocyte Reprograming Promotes Homology-Directed DNA Repair to Correct Metabolic Disease in Mice After Transplantation.

VanLith CJ, Guthman RM, Nicolas CT, Allen KL, Liu Y, Chilton JA, Tritz ZP, Nyberg SL, Kaiser RA, Lillegard JB, Hickey RD. VanLith CJ, et al. Among authors: nicolas ct. Hepatol Commun. 2019 Feb 15;3(4):558-573. doi: 10.1002/hep4.1315. eCollection 2019 Apr. Hepatol Commun. 2019. PMID: 30976745 Free PMC article.

7

Ex Vivo Cell Therapy by Ectopic Hepatocyte Transplantation Treats the Porcine Tyrosinemia Model of Acute Liver Failure.

Nicolas CT, Kaiser RA, Hickey RD, Allen KL, Du Z, VanLith CJ, Guthman RM, Amiot B, Suksanpaisan L, Han B, Francipane MG, Cheikhi A, Jiang H, Bansal A, Pandey MK, Garg I, Lowe V, Bhagwate A, O'Brien D, Kocher JA, DeGrado TR, Nyberg SL, Lagasse E, Lillegard JB. Nicolas CT, et al. Mol Ther Methods Clin Dev. 2020 Jul 10;18:738-750. doi: 10.1016/j.omtm.2020.07.009. eCollection 2020 Sep 11. Mol Ther Methods Clin Dev. 2020. PMID: 32913881 Free PMC article.

8

In vivo lentiviral vector gene therapy to cure hereditary tyrosinemia type 1 and prevent development of precancerous and cancerous lesions.

Nicolas CT, VanLith CJ, Hickey RD, Du Z, Hillin LG, Guthman RM, Cao WJ, Haugo B, Lillegard A, Roy D, Bhagwate A, O'Brien D, Kocher JP, Kaiser RA, Russell SJ, Lillegard JB. Nicolas CT, et al. Nat Commun. 2022 Aug 25;13(1):5012. doi: 10.1038/s41467-022-32576-7. Nat Commun. 2022. PMID: 36008405 Free PMC article.

9

Activation of homology-directed DNA repair plays key role in CRISPR-mediated genome correction.

Mondal G, VanLith CJ, Nicolas CT, Thompson WS, Cao WS, Hillin L, Haugo BJ, Brien DRO, Kocher JP, Kaiser RA, Lillegard JB. Mondal G, et al. Among authors: nicolas ct. Gene Ther. 2023 Apr;30(3-4):386-397. doi: 10.1038/s41434-022-00369-8. Epub 2022 Oct 19. Gene Ther. 2023. PMID: 36258038

10

Cell therapy in chronic liver disease.

Nicolas CT, Wang Y, Nyberg SL. Nicolas CT, et al. Curr Opin Gastroenterol. 2016 May;32(3):189-94. doi: 10.1097/MOG.0000000000000262. Curr Opin Gastroenterol. 2016. PMID: 26950359 Free PMC article. Review.

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