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A computational systems biology software platform for multiscale modeling and simulation: integrating whole-body physiology, disease biology, and molecular reaction networks.
Eissing T, Kuepfer L, Becker C, Block M, Coboeken K, Gaub T, Goerlitz L, Jaeger J, Loosen R, Ludewig B, Meyer M, Niederalt C, Sevestre M, Siegmund HU, Solodenko J, Thelen K, Telle U, Weiss W, Wendl T, Willmann S, Lippert J. Eissing T, et al. Among authors: niederalt c. Front Physiol. 2011 Feb 24;2:4. doi: 10.3389/fphys.2011.00004. eCollection 2011. Front Physiol. 2011. PMID: 21483730 Free PMC article.
Spatio-temporal simulation of first pass drug perfusion in the liver.
Schwen LO, Krauss M, Niederalt C, Gremse F, Kiessling F, Schenk A, Preusser T, Kuepfer L. Schwen LO, et al. Among authors: niederalt c. PLoS Comput Biol. 2014 Mar 13;10(3):e1003499. doi: 10.1371/journal.pcbi.1003499. eCollection 2014 Mar. PLoS Comput Biol. 2014. PMID: 24625393 Free PMC article.
Applied Concepts in PBPK Modeling: How to Build a PBPK/PD Model.
Kuepfer L, Niederalt C, Wendl T, Schlender JF, Willmann S, Lippert J, Block M, Eissing T, Teutonico D. Kuepfer L, et al. Among authors: niederalt c. CPT Pharmacometrics Syst Pharmacol. 2016 Oct;5(10):516-531. doi: 10.1002/psp4.12134. Epub 2016 Oct 19. CPT Pharmacometrics Syst Pharmacol. 2016. PMID: 27653238 Free PMC article.
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