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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1987 1
1993 1
1997 1
2001 1
2003 2
2004 2
2005 2
2006 2
2007 5
2008 6
2009 5
2010 4
2011 13
2012 15
2013 10
2014 4
2015 5
2016 6
2017 14
2018 16
2019 13
2020 11
2021 13
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137 results
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Page 1
Senolytics improve physical function and increase lifespan in old age.
Xu M, Pirtskhalava T, Farr JN, Weigand BM, Palmer AK, Weivoda MM, Inman CL, Ogrodnik MB, Hachfeld CM, Fraser DG, Onken JL, Johnson KO, Verzosa GC, Langhi LGP, Weigl M, Giorgadze N, LeBrasseur NK, Miller JD, Jurk D, Singh RJ, Allison DB, Ejima K, Hubbard GB, Ikeno Y, Cubro H, Garovic VD, Hou X, Weroha SJ, Robbins PD, Niedernhofer LJ, Khosla S, Tchkonia T, Kirkland JL. Xu M, et al. Among authors: niedernhofer lj. Nat Med. 2018 Aug;24(8):1246-1256. doi: 10.1038/s41591-018-0092-9. Epub 2018 Jul 9. Nat Med. 2018. PMID: 29988130 Free PMC article.
The Achilles' heel of senescent cells: from transcriptome to senolytic drugs.
Zhu Y, Tchkonia T, Pirtskhalava T, Gower AC, Ding H, Giorgadze N, Palmer AK, Ikeno Y, Hubbard GB, Lenburg M, O'Hara SP, LaRusso NF, Miller JD, Roos CM, Verzosa GC, LeBrasseur NK, Wren JD, Farr JN, Khosla S, Stout MB, McGowan SJ, Fuhrmann-Stroissnigg H, Gurkar AU, Zhao J, Colangelo D, Dorronsoro A, Ling YY, Barghouthy AS, Navarro DC, Sano T, Robbins PD, Niedernhofer LJ, Kirkland JL. Zhu Y, et al. Among authors: niedernhofer lj. Aging Cell. 2015 Aug;14(4):644-58. doi: 10.1111/acel.12344. Epub 2015 Apr 22. Aging Cell. 2015. PMID: 25754370 Free PMC article.
Fisetin is a senotherapeutic that extends health and lifespan.
Yousefzadeh MJ, Zhu Y, McGowan SJ, Angelini L, Fuhrmann-Stroissnigg H, Xu M, Ling YY, Melos KI, Pirtskhalava T, Inman CL, McGuckian C, Wade EA, Kato JI, Grassi D, Wentworth M, Burd CE, Arriaga EA, Ladiges WL, Tchkonia T, Kirkland JL, Robbins PD, Niedernhofer LJ. Yousefzadeh MJ, et al. Among authors: niedernhofer lj. EBioMedicine. 2018 Oct;36:18-28. doi: 10.1016/j.ebiom.2018.09.015. Epub 2018 Sep 29. EBioMedicine. 2018. PMID: 30279143 Free PMC article.
The Clinical Potential of Senolytic Drugs.
Kirkland JL, Tchkonia T, Zhu Y, Niedernhofer LJ, Robbins PD. Kirkland JL, et al. Among authors: niedernhofer lj. J Am Geriatr Soc. 2017 Oct;65(10):2297-2301. doi: 10.1111/jgs.14969. Epub 2017 Sep 4. J Am Geriatr Soc. 2017. PMID: 28869295 Free PMC article.
Molecular pathology endpoints useful for aging studies.
Niedernhofer LJ, Kirkland JL, Ladiges W. Niedernhofer LJ, et al. Ageing Res Rev. 2017 May;35:241-249. doi: 10.1016/j.arr.2016.09.012. Epub 2016 Oct 6. Ageing Res Rev. 2017. PMID: 27721062 Free PMC article. Review.
Hsp90 inhibitors as senolytic drugs to extend healthy aging.
Fuhrmann-Stroissnigg H, Niedernhofer LJ, Robbins PD. Fuhrmann-Stroissnigg H, et al. Among authors: niedernhofer lj. Cell Cycle. 2018;17(9):1048-1055. doi: 10.1080/15384101.2018.1475828. Epub 2018 Jul 23. Cell Cycle. 2018. PMID: 29886783 Free PMC article. Review.
Genetics of extreme human longevity to guide drug discovery for healthy ageing.
Zhang ZD, Milman S, Lin JR, Wierbowski S, Yu H, Barzilai N, Gorbunova V, Ladiges WC, Niedernhofer LJ, Suh Y, Robbins PD, Vijg J. Zhang ZD, et al. Among authors: niedernhofer lj. Nat Metab. 2020 Aug;2(8):663-672. doi: 10.1038/s42255-020-0247-0. Epub 2020 Jul 27. Nat Metab. 2020. PMID: 32719537 Free PMC article. Review.
Senolytic Drugs: Reducing Senescent Cell Viability to Extend Health Span.
Robbins PD, Jurk D, Khosla S, Kirkland JL, LeBrasseur NK, Miller JD, Passos JF, Pignolo RJ, Tchkonia T, Niedernhofer LJ. Robbins PD, et al. Among authors: niedernhofer lj. Annu Rev Pharmacol Toxicol. 2021 Jan 6;61:779-803. doi: 10.1146/annurev-pharmtox-050120-105018. Epub 2020 Sep 30. Annu Rev Pharmacol Toxicol. 2021. PMID: 32997601 Free PMC article.
Mouse Models of Accelerated Cellular Senescence.
Yousefzadeh MJ, Melos KI, Angelini L, Burd CE, Robbins PD, Niedernhofer LJ. Yousefzadeh MJ, et al. Among authors: niedernhofer lj. Methods Mol Biol. 2019;1896:203-230. doi: 10.1007/978-1-4939-8931-7_17. Methods Mol Biol. 2019. PMID: 30474850 Free PMC article.
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