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A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis.
Niedernhofer LJ, Garinis GA, Raams A, Lalai AS, Robinson AR, Appeldoorn E, Odijk H, Oostendorp R, Ahmad A, van Leeuwen W, Theil AF, Vermeulen W, van der Horst GT, Meinecke P, Kleijer WJ, Vijg J, Jaspers NG, Hoeijmakers JH. Niedernhofer LJ, et al. Nature. 2006 Dec 21;444(7122):1038-43. doi: 10.1038/nature05456. Nature. 2006. PMID: 17183314
A mouse model of accelerated liver aging caused by a defect in DNA repair.
Gregg SQ, Gutiérrez V, Robinson AR, Woodell T, Nakao A, Ross MA, Michalopoulos GK, Rigatti L, Rothermel CE, Kamileri I, Garinis GA, Stolz DB, Niedernhofer LJ. Gregg SQ, et al. Among authors: niedernhofer lj. Hepatology. 2012 Feb;55(2):609-21. doi: 10.1002/hep.24713. Hepatology. 2012. PMID: 21953681 Free PMC article.
Premature aging-related peripheral neuropathy in a mouse model of progeria.
Goss JR, Stolz DB, Robinson AR, Zhang M, Arbujas N, Robbins PD, Glorioso JC, Niedernhofer LJ. Goss JR, et al. Among authors: niedernhofer lj. Mech Ageing Dev. 2011 Aug;132(8-9):437-42. doi: 10.1016/j.mad.2011.04.010. Epub 2011 May 11. Mech Ageing Dev. 2011. PMID: 21596054 Free PMC article.
Genotoxic stress accelerates age-associated degenerative changes in intervertebral discs.
Nasto LA, Wang D, Robinson AR, Clauson CL, Ngo K, Dong Q, Roughley P, Epperly M, Huq SM, Pola E, Sowa G, Robbins PD, Kang J, Niedernhofer LJ, Vo NV. Nasto LA, et al. Among authors: niedernhofer lj. Mech Ageing Dev. 2013 Jan-Feb;134(1-2):35-42. doi: 10.1016/j.mad.2012.11.002. Epub 2012 Dec 19. Mech Ageing Dev. 2013. PMID: 23262094 Free PMC article.
NF-κB inhibition delays DNA damage-induced senescence and aging in mice.
Tilstra JS, Robinson AR, Wang J, Gregg SQ, Clauson CL, Reay DP, Nasto LA, St Croix CM, Usas A, Vo N, Huard J, Clemens PR, Stolz DB, Guttridge DC, Watkins SC, Garinis GA, Wang Y, Niedernhofer LJ, Robbins PD. Tilstra JS, et al. Among authors: niedernhofer lj. J Clin Invest. 2012 Jul;122(7):2601-12. doi: 10.1172/JCI45785. Epub 2012 Jun 18. J Clin Invest. 2012. PMID: 22706308 Free PMC article.
Immunodetection of DNA repair endonuclease ERCC1-XPF in human tissue.
Bhagwat NR, Roginskaya VY, Acquafondata MB, Dhir R, Wood RD, Niedernhofer LJ. Bhagwat NR, et al. Among authors: niedernhofer lj. Cancer Res. 2009 Sep 1;69(17):6831-8. doi: 10.1158/0008-5472.CAN-09-1237. Cancer Res. 2009. PMID: 19723666 Free PMC article.
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