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NF-κB inhibition delays DNA damage-induced senescence and aging in mice.
Tilstra JS, Robinson AR, Wang J, Gregg SQ, Clauson CL, Reay DP, Nasto LA, St Croix CM, Usas A, Vo N, Huard J, Clemens PR, Stolz DB, Guttridge DC, Watkins SC, Garinis GA, Wang Y, Niedernhofer LJ, Robbins PD. Tilstra JS, et al. Among authors: niedernhofer lj. J Clin Invest. 2012 Jul;122(7):2601-12. doi: 10.1172/JCI45785. Epub 2012 Jun 18. J Clin Invest. 2012. PMID: 22706308 Free PMC article.
A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis.
Niedernhofer LJ, Garinis GA, Raams A, Lalai AS, Robinson AR, Appeldoorn E, Odijk H, Oostendorp R, Ahmad A, van Leeuwen W, Theil AF, Vermeulen W, van der Horst GT, Meinecke P, Kleijer WJ, Vijg J, Jaspers NG, Hoeijmakers JH. Niedernhofer LJ, et al. Nature. 2006 Dec 21;444(7122):1038-43. doi: 10.1038/nature05456. Nature. 2006. PMID: 17183314
First reported patient with human ERCC1 deficiency has cerebro-oculo-facio-skeletal syndrome with a mild defect in nucleotide excision repair and severe developmental failure.
Jaspers NG, Raams A, Silengo MC, Wijgers N, Niedernhofer LJ, Robinson AR, Giglia-Mari G, Hoogstraten D, Kleijer WJ, Hoeijmakers JH, Vermeulen W. Jaspers NG, et al. Among authors: niedernhofer lj. Am J Hum Genet. 2007 Mar;80(3):457-66. doi: 10.1086/512486. Epub 2007 Jan 29. Am J Hum Genet. 2007. PMID: 17273966 Free PMC article.
Impaired genome maintenance suppresses the growth hormone--insulin-like growth factor 1 axis in mice with Cockayne syndrome.
van der Pluijm I, Garinis GA, Brandt RM, Gorgels TG, Wijnhoven SW, Diderich KE, de Wit J, Mitchell JR, van Oostrom C, Beems R, Niedernhofer LJ, Velasco S, Friedberg EC, Tanaka K, van Steeg H, Hoeijmakers JH, van der Horst GT. van der Pluijm I, et al. Among authors: niedernhofer lj. PLoS Biol. 2007 Jan;5(1):e2. doi: 10.1371/journal.pbio.0050002. PLoS Biol. 2007. PMID: 17326724 Free PMC article.
ERCC1-XPF endonuclease facilitates DNA double-strand break repair.
Ahmad A, Robinson AR, Duensing A, van Drunen E, Beverloo HB, Weisberg DB, Hasty P, Hoeijmakers JH, Niedernhofer LJ. Ahmad A, et al. Among authors: niedernhofer lj. Mol Cell Biol. 2008 Aug;28(16):5082-92. doi: 10.1128/MCB.00293-08. Epub 2008 Jun 9. Mol Cell Biol. 2008. PMID: 18541667 Free PMC article.
Delayed and accelerated aging share common longevity assurance mechanisms.
Schumacher B, van der Pluijm I, Moorhouse MJ, Kosteas T, Robinson AR, Suh Y, Breit TM, van Steeg H, Niedernhofer LJ, van Ijcken W, Bartke A, Spindler SR, Hoeijmakers JH, van der Horst GT, Garinis GA. Schumacher B, et al. Among authors: niedernhofer lj. PLoS Genet. 2008 Aug 15;4(8):e1000161. doi: 10.1371/journal.pgen.1000161. PLoS Genet. 2008. PMID: 18704162 Free PMC article.
Accelerated aging of intervertebral discs in a mouse model of progeria.
Vo N, Seo HY, Robinson A, Sowa G, Bentley D, Taylor L, Studer R, Usas A, Huard J, Alber S, Watkins SC, Lee J, Coehlo P, Wang D, Loppini M, Robbins PD, Niedernhofer LJ, Kang J. Vo N, et al. Among authors: niedernhofer lj. J Orthop Res. 2010 Dec;28(12):1600-7. doi: 10.1002/jor.21153. J Orthop Res. 2010. PMID: 20973062 Free PMC article.
182 results