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In nondiabetic, human immunodeficiency virus-infected patients with lipodystrophy, hepatic insulin extraction and posthepatic insulin clearance rate are decreased in proportion to insulin resistance.
Haugaard SB, Andersen O, Hansen BR, Andersen UB, Vølund A, Iversen J, Nielsen JO, Madsbad S. Haugaard SB, et al. Among authors: nielsen jo. Metabolism. 2005 Feb;54(2):171-9. doi: 10.1016/j.metabol.2004.08.009. Metabolism. 2005. PMID: 15690310 Clinical Trial.
Circulating sex hormones and gene expression of subcutaneous adipose tissue oestrogen and alpha-adrenergic receptors in HIV-lipodystrophy: implications for fat distribution.
Andersen O, Pedersen SB, Svenstrup B, Hansen BR, Paulsen SK, Rathje GS, Richelsen B, Nielsen JO, Madsbad S, Iversen J, Haugaard SB. Andersen O, et al. Among authors: nielsen jo. Clin Endocrinol (Oxf). 2007 Aug;67(2):250-8. doi: 10.1111/j.1365-2265.2007.02872.x. Epub 2007 May 24. Clin Endocrinol (Oxf). 2007. PMID: 17524033
Insulin secretion in lipodystrophic HIV-infected patients is associated with high levels of nonglucose secretagogues and insulin resistance of beta-cells.
Haugaard SB, Andersen O, Storgaard H, Dela F, Holst JJ, Iversen J, Nielsen JO, Madsbad S. Haugaard SB, et al. Among authors: nielsen jo. Am J Physiol Endocrinol Metab. 2004 Oct;287(4):E677-85. doi: 10.1152/ajpendo.00009.2004. Epub 2004 May 18. Am J Physiol Endocrinol Metab. 2004. PMID: 15149949 Clinical Trial.
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