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Identification of a stage selector element in the human gamma-globin gene promoter that fosters preferential interaction with the 5' HS2 enhancer when in competition with the beta-promoter.
Jane SM, Ney PA, Vanin EF, Gumucio DL, Nienhuis AW. Jane SM, et al. Among authors: nienhuis aw. EMBO J. 1992 Aug;11(8):2961-9. EMBO J. 1992. PMID: 1639067 Free PMC article.
Identification of two novel regulatory elements within the 5'-untranslated region of the human A gamma-globin gene.
Amrolia PJ, Cunningham JM, Ney P, Nienhuis AW, Jane SM. Amrolia PJ, et al. Among authors: nienhuis aw. J Biol Chem. 1995 May 26;270(21):12892-8. doi: 10.1074/jbc.270.21.12892. J Biol Chem. 1995. PMID: 7759548
Transcriptional regulation of human gamma globin gene expression.
McDonagh KT, Lin H, Bodine DM, Lowrey C, Purucker M, Ley T, Nienhuis AW. McDonagh KT, et al. Among authors: nienhuis aw. Prog Clin Biol Res. 1989;316A:149-62. Prog Clin Biol Res. 1989. PMID: 2594803 No abstract available.
Recombinant adeno-associated virus (rAAV)-mediated expression of a human gamma-globin gene in human progenitor-derived erythroid cells.
Miller JL, Donahue RE, Sellers SE, Samulski RJ, Young NS, Nienhuis AW. Miller JL, et al. Among authors: nienhuis aw. Proc Natl Acad Sci U S A. 1994 Oct 11;91(21):10183-7. doi: 10.1073/pnas.91.21.10183. Proc Natl Acad Sci U S A. 1994. PMID: 7524085 Free PMC article.
Regulatory regions flanking the human fetal gamma-globin genes.
Lin HJ, Bodine DM, Rutherford TR, Anagnou NP, McDonagh KT, Ley TJ, Nienhuis AW. Lin HJ, et al. Among authors: nienhuis aw. Ann N Y Acad Sci. 1989;565:13-22. doi: 10.1111/j.1749-6632.1989.tb24145.x. Ann N Y Acad Sci. 1989. PMID: 2476058 No abstract available.
Stable gene transfer and tissue-specific expression of a human globin gene using adenoviral vectors.
Karlsson S, Van Doren K, Schweiger SG, Nienhuis AW, Gluzman Y. Karlsson S, et al. Among authors: nienhuis aw. EMBO J. 1986 Sep;5(9):2377-85. EMBO J. 1986. PMID: 3780679 Free PMC article.
Human globin gene promoter sequences are sufficient for specific expression of a hybrid gene transfected into tissue culture cells.
Rutherford T, Nienhuis AW. Rutherford T, et al. Among authors: nienhuis aw. Mol Cell Biol. 1987 Jan;7(1):398-402. doi: 10.1128/mcb.7.1.398. Mol Cell Biol. 1987. PMID: 3561396 Free PMC article.
Methylation-enhanced binding of Sp1 to the stage selector element of the human gamma-globin gene promoter may regulate development specificity of expression.
Jane SM, Gumucio DL, Ney PA, Cunningham JM, Nienhuis AW. Jane SM, et al. Among authors: nienhuis aw. Mol Cell Biol. 1993 Jun;13(6):3272-81. doi: 10.1128/mcb.13.6.3272. Mol Cell Biol. 1993. PMID: 7684493 Free PMC article.
Nienhuis. EMBO J. 11:2691-2699, 1992). The element binds two proteins, the ubiquitous activator Sp1 and a protein previously known as -50 gamma and now named the stage selector protein (SSP). ...
Nienhuis. EMBO J. 11:2691-2699, 1992). The element binds two proteins, the ubiquitous activator Sp1 and a protein previously known as
Activation of the human beta-globin promoter in K562 cells by DNA sequences 5' to the fetal gamma- or embryonic zeta-globin genes.
Lin HJ, Anagnou NP, Rutherford TR, Shimada T, Nienhuis AW. Lin HJ, et al. Among authors: nienhuis aw. J Clin Invest. 1987 Aug;80(2):374-80. doi: 10.1172/JCI113082. J Clin Invest. 1987. PMID: 3611352 Free PMC article.
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