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185 results

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Page 1
Pharmacological updates of nifuroxazide: Promising preclinical effects and the underlying molecular mechanisms.
Althagafy HS, El-Aziz MKA, Ibrahim IM, Abd-Alhameed EK, Hassanein EHM. Althagafy HS, et al. Eur J Pharmacol. 2023 Jul 15;951:175776. doi: 10.1016/j.ejphar.2023.175776. Epub 2023 May 14. Eur J Pharmacol. 2023. PMID: 37192715 Review.
Nifuroxazide (NFX) is a safe nitrofuran antibacterial drug used clinically to treat acute diarrhea and infectious traveler diarrhea or colitis. ...
Nifuroxazide (NFX) is a safe nitrofuran antibacterial drug used clinically to treat acute diarrhea and infectious traveler diarrhea o …
Nifuroxazide boosts the anticancer efficacy of palbociclib-induced senescence by dual inhibition of STAT3 and CDK2 in triple-negative breast cancer.
Wang X, Shi W, Wang X, Lu JJ, He P, Zhang H, Chen X. Wang X, et al. Cell Death Discov. 2023 Sep 26;9(1):355. doi: 10.1038/s41420-023-01658-w. Cell Death Discov. 2023. PMID: 37752122 Free PMC article.
Here we report that combining palbociclib with the STAT3 inhibitor nifuroxazide uncouples SASP production from senescence-associated cell cycle exit. Moreover, we identified nifuroxazide as a CDK2 inhibitor that synergistically promotes palbociclib-induced growth ar …
Here we report that combining palbociclib with the STAT3 inhibitor nifuroxazide uncouples SASP production from senescence-associated …
Nifuroxazide suppresses PD-L1 expression and enhances the efficacy of radiotherapy in hepatocellular carcinoma.
Zhao T, Wei P, Zhang C, Zhou S, Liang L, Guo S, Yin Z, Cheng S, Gan Z, Xia Y, Zhang Y, Guo S, Zhong J, Yang Z, Tu F, Wang Q, Bai J, Ren F, Feng Z, Jia H. Zhao T, et al. Elife. 2024 Mar 5;12:RP90911. doi: 10.7554/eLife.90911. Elife. 2024. PMID: 38441416 Free PMC article.
In this study, we investigated whether nifuroxazide could enhance the efficacy of radiotherapy in HCC by reducing PD-L1 expression. ...Importantly, nifuroxazide limited the increased expression of PD-L1 in tumor tissues induced by radiation therapy. ...
In this study, we investigated whether nifuroxazide could enhance the efficacy of radiotherapy in HCC by reducing PD-L1 expression. . …
Nifuroxazide Has Better Efficacy Than Probiotic Treatment in Adult Patients with Acute Diarrheal Syndrome.
Husic-Selimovic A, Custovic N, Sivac N, Glamoclija U, Sukalo A, Mehic M. Husic-Selimovic A, et al. Mater Sociomed. 2022 Dec;34(4):267-271. doi: 10.5455/msm.2022.34.267-271. Mater Sociomed. 2022. PMID: 36936893 Free PMC article.
Patients were feeling better and there was a trend of reporting better therapy efficacy in nifuroxazide group. Subjective assessment of therapy tolerability was also better in nifuroxazide group. ...CONCLUSION: Although probiotics are sometimes used in the treatment …
Patients were feeling better and there was a trend of reporting better therapy efficacy in nifuroxazide group. Subjective assessment …
Nifuroxazide in combination with CpG ODN exerts greater efficacy against hepatocellular carcinoma.
Wang Y, Liu W, Liu M, Wang H, Zhou L, Chen J, Sun H, Wei X, Fan M, Yang M, Liu Z, Yang Z, Zhong J, Lu C, Zhao T, Jia H. Wang Y, et al. Int Immunopharmacol. 2022 Jul;108:108911. doi: 10.1016/j.intimp.2022.108911. Epub 2022 Jun 1. Int Immunopharmacol. 2022. PMID: 35729838
Moreover, as a broad-spectrum antimicrobial drug, nifuroxazide exhibited an anti-HCC effect through activation of p-Stat3. Here, we tested the effect of nifuroxazide on HCC in vitro and then explored the therapeutic effect of combined nifuroxazide and CpG ODN …
Moreover, as a broad-spectrum antimicrobial drug, nifuroxazide exhibited an anti-HCC effect through activation of p-Stat3. Here, we t …
Nifuroxazide induces apoptosis, inhibits cell migration and invasion in osteosarcoma.
Luo Y, Zeng A, Fang A, Song L, Fan C, Zeng C, Ye T, Chen H, Tu C, Xie Y. Luo Y, et al. Invest New Drugs. 2019 Oct;37(5):1006-1013. doi: 10.1007/s10637-019-00724-4. Epub 2019 Jan 25. Invest New Drugs. 2019. PMID: 30680584
Interestingly, nifuroxazide showed low toxicity to non-tumor cells (HEK 293 T). In addition, ROS-mitochondrial mediated apoptosis was observed after treatment of nifuroxazide. Moreover, nifuroxazide could significantly inhibit osteosarcoma cells migration and …
Interestingly, nifuroxazide showed low toxicity to non-tumor cells (HEK 293 T). In addition, ROS-mitochondrial mediated apoptosis was …
Pro-Nifuroxazide Self-Assembly Leads to Triggerable Nanomedicine for Anti-cancer Therapy.
Misra SK, Wu Z, Ostadhossein F, Ye M, Boateng K, Schulten K, Tajkhorshid E, Pan D. Misra SK, et al. ACS Appl Mater Interfaces. 2019 May 22;11(20):18074-18089. doi: 10.1021/acsami.9b01343. Epub 2019 May 13. ACS Appl Mater Interfaces. 2019. PMID: 31013055 Free PMC article.
We have synthesized a novel lipase-labile SN-2 phospholipid prodrug from a clinically investigated STAT3 inhibitor, nifuroxazide (Pro-nifuroxazide), which can be regioselectively cleaved by the membrane-abundant enzymes in cancer cells. ...Results indicated that Pro …
We have synthesized a novel lipase-labile SN-2 phospholipid prodrug from a clinically investigated STAT3 inhibitor, nifuroxazide (Pro …
Toward a repositioning of the antibacterial drug nifuroxazide for cancer treatment.
Bailly C. Bailly C. Drug Discov Today. 2019 Sep;24(9):1930-1936. doi: 10.1016/j.drudis.2019.06.017. Epub 2019 Jun 28. Drug Discov Today. 2019. PMID: 31260646 Review.
Nifuroxazide (NFX) is a broad-spectrum antibacterial drug that has been used for the treatment of infectious diarrhoea since 1966. ...
Nifuroxazide (NFX) is a broad-spectrum antibacterial drug that has been used for the treatment of infectious diarrhoea since 1966. .. …
Nifuroxazide Mitigates Angiogenesis in Ehlrich's Solid Carcinoma: Molecular Docking, Bioinformatic and Experimental Studies on Inhibition of Il-6/Jak2/Stat3 Signaling.
El-Sherbiny M, El-Sayed RM, Helal MA, Ibrahiem AT, Elmahdi HS, Eladl MA, Bilay SE, Alshahrani AM, Tawfik MK, Hamed ZE, Mohamed AO, Zaitone SA. El-Sherbiny M, et al. Molecules. 2021 Nov 13;26(22):6858. doi: 10.3390/molecules26226858. Molecules. 2021. PMID: 34833950 Free PMC article.
Nifuroxazide is an antidiarrheal medication that has promising anticancer activity against diverse types of tumors. ...The experimental groups were as follows: EST control, EST + nifuroxazide (5 mg/kg), and EST + nifuroxazide (10 mg/kg). Nifuroxazide w …
Nifuroxazide is an antidiarrheal medication that has promising anticancer activity against diverse types of tumors. ...The experiment …
Nifuroxazide Activates the Parthanatos to Overcome TMPRSS2:ERG Fusion-Positive Prostate Cancer.
Li C, Zhang J, Wu Q, Kumar A, Pan G, Kelvin DJ. Li C, et al. Mol Cancer Ther. 2023 Mar 2;22(3):306-316. doi: 10.1158/1535-7163.MCT-22-0159. Mol Cancer Ther. 2023. PMID: 36622760 Free PMC article.
In vivo and in vitro methods revealed that nifuroxazide (NFZ) inhibited the proliferation of a TMPRSS2:ERG fusion-positive prostate cancer cell line (VCaP) with an IC50 lower than that of ERG-negative prostate cancer cell lines (LNCaP, DU145, and WPMY cells). ...
In vivo and in vitro methods revealed that nifuroxazide (NFZ) inhibited the proliferation of a TMPRSS2:ERG fusion-positive prostate c …
185 results