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Preclinical and clinical effects of Nigella sativa and its constituent, thymoquinone: A review.
Gholamnezhad Z, Havakhah S, Boskabady MH. Gholamnezhad Z, et al. J Ethnopharmacol. 2016 Aug 22;190:372-86. doi: 10.1016/j.jep.2016.06.061. Epub 2016 Jun 27. J Ethnopharmacol. 2016. PMID: 27364039 Review.
ETHNOPHARMACOLOGICAL RELEVANCE: Nigella sativa (N. sativa) L. (Ranunculaceae), well known as black cumin, has been used as a herbal medicine that has a rich historical background. ...However, there were some confounding factors in the reviewed clinical trials …
ETHNOPHARMACOLOGICAL RELEVANCE: Nigella sativa (N. sativa) L. (Ranunculaceae), well known as black cumin, has been used …
Nigella sativa L. and COVID-19: A Glance at The Anti-COVID-19 Chemical Constituents, Clinical Trials, Inventions, and Patent Literature.
Imran M, Khan SA, Abida, Alshammari MK, Alkhaldi SM, Alshammari FN, Kamal M, Alam O, Asdaq SMB, Alzahrani AK, Jomah S. Imran M, et al. Molecules. 2022 Apr 25;27(9):2750. doi: 10.3390/molecules27092750. Molecules. 2022. PMID: 35566101 Free PMC article. Review.
Scientists have been identifying remedies for its prevention and treatment from all possible sources, including plants. Nigella sativa L. (NS) is an important medicinal plant of Islamic value. This review highlights the anti-COVID-19 potential, clinical trials, inve …
Scientists have been identifying remedies for its prevention and treatment from all possible sources, including plants. Nigella sa …
The effect of a hydrogel made by Nigella sativa L. on acne vulgaris: A randomized double-blind clinical trial.
Soleymani S, Zargaran A, Farzaei MH, Iranpanah A, Heydarpour F, Najafi F, Rahimi R. Soleymani S, et al. Phytother Res. 2020 Nov;34(11):3052-3062. doi: 10.1002/ptr.6739. Epub 2020 Jun 17. Phytother Res. 2020. PMID: 32548864 Clinical Trial.
Nigella sativa L. (black seed) is one of the main medicinal plants frequently cited in traditional Persian medicine manuscripts for management of acne vulgaris. The present study was designed to investigate the efficacy of a topical preparation from N. sativa …
Nigella sativa L. (black seed) is one of the main medicinal plants frequently cited in traditional Persian medicine manuscript …
Effects of Nigella sativa on VCAM-1 and ICAM-1: A systematic review of preclinical and clinical studies.
Faghfoori Z, Javadivala Z, Malek Mahdavi A. Faghfoori Z, et al. J Cardiovasc Thorac Res. 2025 Mar 18;17(1):12-19. doi: 10.34172/jcvtr.025.33343. eCollection 2025 Mar. J Cardiovasc Thorac Res. 2025. PMID: 40365513 Free PMC article. Review.
The objective of present review was to assess all studies about effect of Nigella sativa (N. sativa) on vascular cell and intercellular adhesion molecules-1 (VCAM-1 and ICAM-1) under different situations. ...In two clinical trials, supplementation with N. …
The objective of present review was to assess all studies about effect of Nigella sativa (N. sativa) on vascular cell a …
Thymoquinone, a major constituent in Nigella sativa seeds, is a potential preventative and treatment option for atherosclerosis.
Majdalawieh AF, Yousef SM, Abu-Yousef IA. Majdalawieh AF, et al. Eur J Pharmacol. 2021 Oct 15;909:174420. doi: 10.1016/j.ejphar.2021.174420. Epub 2021 Aug 12. Eur J Pharmacol. 2021. PMID: 34391767 Review.
Nonpharmacological interventions to treat chronic diseases like atherosclerosis have gained considerable attention in recent years. Thymoquinone (TQ), the major bioactive constituent of Nigella sativa seeds, presents one such example of a natural therapeutic …
Nonpharmacological interventions to treat chronic diseases like atherosclerosis have gained considerable attention in recent years. Thymo …
A randomized, double-blind, placebo-controlled study to evaluate the benefits of a standardized Nigella sativa oil containing 5% thymoquinone in reducing the symptoms of seasonal allergy.
Majeed A, Majeed S, Parameswarappa AK, Murali A, Gudimallam S, Siddegowda C, Chandrashekar H, Mundkur L. Majeed A, et al. Medicine (Baltimore). 2024 Aug 9;103(32):e39243. doi: 10.1097/MD.0000000000039243. Medicine (Baltimore). 2024. PMID: 39121267 Free PMC article. Clinical Trial.
A phase I clinical trial to evaluate the safety of thymoquinone-rich black cumin oil (BlaQmax ) on healthy subjects: Randomized, double-blinded, placebo-controlled prospective study.
Thomas JV, Mohan ME, Prabhakaran P, Das S S, Maliakel B, I M K. Thomas JV, et al. Toxicol Rep. 2022 Apr 20;9:999-1007. doi: 10.1016/j.toxrep.2022.04.020. eCollection 2022. Toxicol Rep. 2022. PMID: 36518481 Free PMC article.
Black cumin or black seed (Nigella sativa L.) is a popular medicinal herb and culinary spice belonging to Ranunculacea family. Thymoquinone (TQ) is the major active phytoconstituent in black cumin and is abundant in the volatile oil fraction. ...
Black cumin or black seed (Nigella sativa L.) is a popular medicinal herb and culinary spice belonging to Ranunculacea family. …
A randomized, double-blind, placebo-controlled, clinical trial to evaluate the benefits of Nigella sativa seeds oil in reducing cardiovascular risks in hypertensive patients.
Shoaei-Hagh P, Kamelan Kafi F, Najafi S, Zamanzadeh M, Heidari Bakavoli A, Ramezani J, Soltanian S, Asili J, Hosseinzadeh H, Eslami S, Taherzadeh Z. Shoaei-Hagh P, et al. Phytother Res. 2021 Aug;35(8):4388-4400. doi: 10.1002/ptr.7140. Epub 2021 May 6. Phytother Res. 2021. PMID: 33957004 Clinical Trial.
The efficacy, safety, and utility of Nigella sativa seeds oil as a complementary treatment for hypertension, glucose control, and lipid metabolism were evaluated. Hypertensive patients in the intervention (n = 26) and placebo (n = 29) groups received 2.5 ml of N. …
The efficacy, safety, and utility of Nigella sativa seeds oil as a complementary treatment for hypertension, glucose control, …
Nigella sativa fixed oil as alternative treatment in management of pain in arthritis rheumatoid.
Mahboubi M, Mohammad Taghizadeh Kashani L, Mahboubi M. Mahboubi M, et al. Phytomedicine. 2018 Jul 15;46:69-77. doi: 10.1016/j.phymed.2018.04.018. Epub 2018 Apr 10. Phytomedicine. 2018. PMID: 30097124 Review.
BACKGROUND: N. sativa seeds is the source of fixed oil, which contain fatty acids and thymoquinone. N. sativa fixed oil topically or orally is used traditionally for management of pain in back, joints, musculoskeletal organs and arthritis rheumatoid. ...RESUL …
BACKGROUND: N. sativa seeds is the source of fixed oil, which contain fatty acids and thymoquinone. N. sativa fixed oil …
Cardiovascular benefits of black cumin (Nigella sativa).
Shabana A, El-Menyar A, Asim M, Al-Azzeh H, Al Thani H. Shabana A, et al. Cardiovasc Toxicol. 2013 Mar;13(1):9-21. doi: 10.1007/s12012-012-9181-z. Cardiovasc Toxicol. 2013. PMID: 22911452 Review.
Black Cumin (Nigella sativa), which belongs to the botanical family of Ranunculaceae, commonly grows in Eastern Europe, the Middle East, and Western Asia. ...We reviewed the literature from 1960 to March 2012 by using the following key words: "Nigella sati …
Black Cumin (Nigella sativa), which belongs to the botanical family of Ranunculaceae, commonly grows in Eastern Europe, the Mi …
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