Niikura T - Search Results

1

Neuronal cell death in Alzheimer's disease and a neuroprotective factor, humanin.

Niikura T, Tajima H, Kita Y. Niikura T, et al. Curr Neuropharmacol. 2006 Apr;4(2):139-47. doi: 10.2174/157015906776359577. Curr Neuropharmacol. 2006. PMID: 18615127 Free PMC article.

2

Evidence for in vivo production of Humanin peptide, a neuroprotective factor against Alzheimer's disease-related insults.

Tajima H, Niikura T, Hashimoto Y, Ito Y, Kita Y, Terashita K, Yamazaki K, Koto A, Aiso S, Nishimoto I. Tajima H, et al. Among authors: niikura t. Neurosci Lett. 2002 May 24;324(3):227-31. doi: 10.1016/s0304-3940(02)00199-4. Neurosci Lett. 2002. PMID: 12009529

3

Two serine residues distinctly regulate the rescue function of Humanin, an inhibiting factor of Alzheimer's disease-related neurotoxicity: functional potentiation by isomerization and dimerization.

Terashita K, Hashimoto Y, Niikura T, Tajima H, Yamagishi Y, Ishizaka M, Kawasumi M, Chiba T, Kanekura K, Yamada M, Nawa M, Kita Y, Aiso S, Nishimoto I. Terashita K, et al. Among authors: niikura t. J Neurochem. 2003 Jun;85(6):1521-38. doi: 10.1046/j.1471-4159.2003.01797.x. J Neurochem. 2003. PMID: 12787071 Free article.

4

[Neuronal cell death by Alzheimer's disease-relevant insults and its rescue].

Niikura T, Hashimoto Y, Tajima H, Ito Y, Nishimoto I. Niikura T, et al. Nihon Ronen Igakkai Zasshi. 2003 Jan;40(1):36-40. doi: 10.3143/geriatrics.40.36. Nihon Ronen Igakkai Zasshi. 2003. PMID: 12649845 Free article. Japanese.

5

Neurotoxic mechanisms by Alzheimer's disease-linked N141I mutant presenilin 2.

Hashimoto Y, Niikura T, Ito Y, Kita Y, Terashita K, Nishimoto I. Hashimoto Y, et al. Among authors: niikura t. J Pharmacol Exp Ther. 2002 Mar;300(3):736-45. doi: 10.1124/jpet.300.3.736. J Pharmacol Exp Ther. 2002. PMID: 11861776

6

Neurotoxic mechanisms triggered by Alzheimer's disease-linked mutant M146L presenilin 1: involvement of NO synthase via a novel pertussis toxin target.

Hashimoto Y, Ito Y, Arakawa E, Kita Y, Terashita K, Niikura T, Nishimoto I. Hashimoto Y, et al. Among authors: niikura t. J Neurochem. 2002 Feb;80(3):426-37. doi: 10.1046/j.0022-3042.2001.00722.x. J Neurochem. 2002. PMID: 11905990 Free article.

7

Death and survival of neuronal cells exposed to Alzheimer's insults.

Niikura T, Hashimoto Y, Tajima H, Nishimoto I. Niikura T, et al. J Neurosci Res. 2002 Nov 1;70(3):380-91. doi: 10.1002/jnr.10354. J Neurosci Res. 2002. PMID: 12391601 Review.

8

Molecular mechanisms for neuronal cell death by Alzheimer's amyloid precursor protein-relevant insults.

Kawasumi M, Hashimoto Y, Chiba T, Kanekura K, Yamagishi Y, Ishizaka M, Tajima H, Niikura T, Nishimoto I. Kawasumi M, et al. Among authors: niikura t. Neurosignals. 2002 Sep-Oct;11(5):236-50. doi: 10.1159/000067424. Neurosignals. 2002. PMID: 12566925 Review.

9

A tripartite motif protein TRIM11 binds and destabilizes Humanin, a neuroprotective peptide against Alzheimer's disease-relevant insults.

Niikura T, Hashimoto Y, Tajima H, Ishizaka M, Yamagishi Y, Kawasumi M, Nawa M, Terashita K, Aiso S, Nishimoto I. Niikura T, et al. Eur J Neurosci. 2003 Mar;17(6):1150-8. doi: 10.1046/j.1460-9568.2003.02553.x. Eur J Neurosci. 2003. PMID: 12670303

10

Humanin antagonists: mutants that interfere with dimerization inhibit neuroprotection by Humanin.

Hashimoto Y, Terashita K, Niikura T, Yamagishi Y, Ishizaka M, Kanekura K, Chiba T, Yamada M, Kita Y, Aiso S, Matsuoka M, Nishimoto I. Hashimoto Y, et al. Among authors: niikura t. Eur J Neurosci. 2004 May;19(9):2356-64. doi: 10.1111/j.0953-816X.2004.03298.x. Eur J Neurosci. 2004. PMID: 15128389

We have previously shown that P3A, S7A, C8A, L9A, L12A, T13A, S14A and P19A mutations nullify the neuroprotective function of HN [Yamagishi, Y., Hashimoto, Y., Niikura, T. & Nishimoto, I. (2003) Peptides, 24, 585-595]. Here we examined whether any of these 'null …

We have previously shown that P3A, S7A, C8A, L9A, L12A, T13A, S14A and P19A mutations nullify the neuroprotective function of HN [Yamagishi, …

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