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Complementation cloning of S2P, a gene encoding a putative metalloprotease required for intramembrane cleavage of SREBPs.
Rawson RB, Zelenski NG, Nijhawan D, Ye J, Sakai J, Hasan MT, Chang TY, Brown MS, Goldstein JL. Rawson RB, et al. Mol Cell. 1997 Dec;1(1):47-57. doi: 10.1016/s1097-2765(00)80006-4. Mol Cell. 1997. PMID: 9659902
Apoptosis in neural development and disease.
Nijhawan D, Honarpour N, Wang X. Nijhawan D, et al. Annu Rev Neurosci. 2000;23:73-87. doi: 10.1146/annurev.neuro.23.1.73. Annu Rev Neurosci. 2000. PMID: 10845059 Review.
P7C3 neuroprotective chemicals function by activating the rate-limiting enzyme in NAD salvage.
Wang G, Han T, Nijhawan D, Theodoropoulos P, Naidoo J, Yadavalli S, Mirzaei H, Pieper AA, Ready JM, McKnight SL. Wang G, et al. Cell. 2014 Sep 11;158(6):1324-1334. doi: 10.1016/j.cell.2014.07.040. Cell. 2014. PMID: 25215490 Free PMC article.
Engineering Forward Genetics into Cultured Cancer Cells for Chemical Target Identification.
Povedano JM, Liou J, Wei D, Srivatsav A, Kim J, Xie Y, Nijhawan D, McFadden DG. Povedano JM, et al. Among authors: nijhawan d. Cell Chem Biol. 2019 Sep 19;26(9):1315-1321.e3. doi: 10.1016/j.chembiol.2019.06.006. Epub 2019 Jul 11. Cell Chem Biol. 2019. PMID: 31303577
Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15.
Han T, Goralski M, Gaskill N, Capota E, Kim J, Ting TC, Xie Y, Williams NS, Nijhawan D. Han T, et al. Among authors: nijhawan d. Science. 2017 Apr 28;356(6336):eaal3755. doi: 10.1126/science.aal3755. Epub 2017 Mar 16. Science. 2017. PMID: 28302793
Cancer vulnerabilities unveiled by genomic loss.
Nijhawan D, Zack TI, Ren Y, Strickland MR, Lamothe R, Schumacher SE, Tsherniak A, Besche HC, Rosenbluh J, Shehata S, Cowley GS, Weir BA, Goldberg AL, Mesirov JP, Root DE, Bhatia SN, Beroukhim R, Hahn WC. Nijhawan D, et al. Cell. 2012 Aug 17;150(4):842-54. doi: 10.1016/j.cell.2012.07.023. Cell. 2012. PMID: 22901813 Free PMC article.
Synthesis and Biological Evaluation of Kibdelone C and Its Simplified Derivatives.
Rujirawanich J, Kim S, Ma AJ, Butler JR, Wang Y, Wang C, Rosen M, Posner B, Nijhawan D, Ready JM. Rujirawanich J, et al. J Am Chem Soc. 2016 Aug 24;138(33):10561-70. doi: 10.1021/jacs.6b05484. Epub 2016 Aug 9. J Am Chem Soc. 2016. PMID: 27459345 Free PMC article.
Discovery of tumor-specific irreversible inhibitors of stearoyl CoA desaturase.
Theodoropoulos PC, Gonzales SS, Winterton SE, Rodriguez-Navas C, McKnight JS, Morlock LK, Hanson JM, Cross B, Owen AE, Duan Y, Moreno JR, Lemoff A, Mirzaei H, Posner BA, Williams NS, Ready JM, Nijhawan D. Theodoropoulos PC, et al. Nat Chem Biol. 2016 Apr;12(4):218-25. doi: 10.1038/nchembio.2016. Epub 2016 Feb 1. Nat Chem Biol. 2016. PMID: 26829472 Free PMC article.
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