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Host defence peptides: antimicrobial and immunomodulatory activity and potential applications for tackling antibiotic-resistant infections.
Nijnik A, Hancock R. Nijnik A, et al. Emerg Health Threats J. 2009;2:e1. doi: 10.3134/ehtj.09.001. Epub 2009 Feb 24. Emerg Health Threats J. 2009. PMID: 22460279 Free PMC article.
Host defence peptides are short cationic molecules produced by the immune systems of most multicellular organisms; they are a class of compounds being actively researched. ...
Host defence peptides are short cationic molecules produced by the immune systems of most multicellular organisms; they are a class o …
Manipulation of innate immunity by a bacterial secreted peptide: lantibiotic nisin Z is selectively immunomodulatory.
Kindrachuk J, Jenssen H, Elliott M, Nijnik A, Magrangeas-Janot L, Pasupuleti M, Thorson L, Ma S, Easton DM, Bains M, Finlay B, Breukink EJ, Georg-Sahl H, Hancock RE. Kindrachuk J, et al. Innate Immun. 2013 Jun;19(3):315-27. doi: 10.1177/1753425912461456. Epub 2012 Oct 29. Innate Immun. 2013. PMID: 23109507
Innate immunity is triggered by a variety of bacterial molecules, resulting in both protective and potentially harmful pro-inflammatory responses. Further, innate immunity also provides a mechanism for the maintenance of homeostasis between the host immune system an …
Innate immunity is triggered by a variety of bacterial molecules, resulting in both protective and potentially harmful pro-inflammato …
Signaling pathways mediating chemokine induction in keratinocytes by cathelicidin LL-37 and flagellin.
Nijnik A, Pistolic J, Filewod NC, Hancock RE. Nijnik A, et al. J Innate Immun. 2012;4(4):377-86. doi: 10.1159/000335901. Epub 2012 Apr 17. J Innate Immun. 2012. PMID: 22516952 Free PMC article.
Cathelicidin LL-37 is a multifunctional immunomodulatory and antimicrobial host defense peptide that has an important role in the immune defenses of the skin and other epithelial barriers. ...These signaling mechanisms mediated the synergistic effects of LL-37 on chemokine …
Cathelicidin LL-37 is a multifunctional immunomodulatory and antimicrobial host defense peptide that has an important role in the imm …
Modulating immunity as a therapy for bacterial infections.
Hancock RE, Nijnik A, Philpott DJ. Hancock RE, et al. Nat Rev Microbiol. 2012 Mar 16;10(4):243-54. doi: 10.1038/nrmicro2745. Nat Rev Microbiol. 2012. PMID: 22421877 Review.
A range of potential immune modulators have been proposed, including innate defence regulator peptides and agonists of innate immune components such as Toll-like receptors and NOD-like receptors....
A range of potential immune modulators have been proposed, including innate defence regulator peptides and agonists of innate immune
The role of the Src family kinase Lyn in the immunomodulatory activities of cathelicidin peptide LL-37 on monocytic cells.
Nijnik A, Pistolic J, Cho P, Filewod NC, Falsafi R, Ramin A, Harder KW, Hancock RE. Nijnik A, et al. J Leukoc Biol. 2012 Apr;91(4):599-607. doi: 10.1189/jlb.0411191. Epub 2012 Jan 13. J Leukoc Biol. 2012. PMID: 22246800 Free PMC article. Clinical Trial.
Cathelicidin LL-37 is a multifunctional, immunomodulatory and antimicrobial host-defense peptide of the human immune system. ...Through systematic siRNA knockdown of SFK members, a requirement for Lyn in mediating LL-37 activity was identified. The involvement of Ly …
Cathelicidin LL-37 is a multifunctional, immunomodulatory and antimicrobial host-defense peptide of the human immune system. ...Throu …
Cathelicidin peptide LL-37 modulates TREM-1 expression and inflammatory responses to microbial compounds.
Amatngalim GD, Nijnik A, Hiemstra PS, Hancock RE. Amatngalim GD, et al. Inflammation. 2011 Oct;34(5):412-25. doi: 10.1007/s10753-010-9248-6. Inflammation. 2011. PMID: 20811938
In this work, the effects of LL-37 on responses to TREM-1 stimulation, alone and in the presence of a range of microbial compounds, were analyzed. ...
In this work, the effects of LL-37 on responses to TREM-1 stimulation, alone and in the presence of a range of microbial compounds, w …
Synthetic cationic peptide IDR-1002 provides protection against bacterial infections through chemokine induction and enhanced leukocyte recruitment.
Nijnik A, Madera L, Ma S, Waldbrook M, Elliott MR, Easton DM, Mayer ML, Mullaly SC, Kindrachuk J, Jenssen H, Hancock RE. Nijnik A, et al. J Immunol. 2010 Mar 1;184(5):2539-50. doi: 10.4049/jimmunol.0901813. Epub 2010 Jan 27. J Immunol. 2010. PMID: 20107187
In this study, an immunomodulatory peptide IDR-1002 was selected from a library of bactenecin derivatives based on its substantially more potent ability to induce chemokines in human PBMCs. ...Chemokine induction by IDR-1002 was found to be mediated through a Gi-cou …
In this study, an immunomodulatory peptide IDR-1002 was selected from a library of bactenecin derivatives based on its substantially …
Human cathelicidin peptide LL-37 modulates the effects of IFN-gamma on APCs.
Nijnik A, Pistolic J, Wyatt A, Tam S, Hancock RE. Nijnik A, et al. J Immunol. 2009 Nov 1;183(9):5788-98. doi: 10.4049/jimmunol.0901491. Epub 2009 Oct 7. J Immunol. 2009. PMID: 19812202
The human cathelicidin peptide LL-37 is a multifunctional immunomodulatory and antimicrobial host defense peptide of the human immune system. ...This study suggests that LL-37 modulates IFN-gamma responses during both the innate and adaptive phases of immune responses, ind …
The human cathelicidin peptide LL-37 is a multifunctional immunomodulatory and antimicrobial host defense peptide of the human immune …
Potential of immunomodulatory host defense peptides as novel anti-infectives.
Easton DM, Nijnik A, Mayer ML, Hancock RE. Easton DM, et al. Trends Biotechnol. 2009 Oct;27(10):582-90. doi: 10.1016/j.tibtech.2009.07.004. Epub 2009 Aug 14. Trends Biotechnol. 2009. PMID: 19683819 Free PMC article. Review.
A fundamentally new strategy for the treatment of infectious disease is the modulation of host immune responses to enhance clearance of infectious agents and reduce tissue damage due to inflammation. ...We discuss the potential and current limitations in exploiting the imm
A fundamentally new strategy for the treatment of infectious disease is the modulation of host immune responses to enhance clearance
Intracellular receptor for human host defense peptide LL-37 in monocytes.
Mookherjee N, Lippert DN, Hamill P, Falsafi R, Nijnik A, Kindrachuk J, Pistolic J, Gardy J, Miri P, Naseer M, Foster LJ, Hancock RE. Mookherjee N, et al. J Immunol. 2009 Aug 15;183(4):2688-96. doi: 10.4049/jimmunol.0802586. Epub 2009 Jul 15. J Immunol. 2009. PMID: 19605696
The human cationic host defense peptide LL-37 has a broad range of immunomodulatory, anti-infective functions. A synthetic innate defense regulator peptide, innate defense regulator 1 (IDR-1), based conceptually on LL-37, was recently shown to selectively modulate i …
The human cationic host defense peptide LL-37 has a broad range of immunomodulatory, anti-infective functions. A synthetic inn …
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