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Antibiotic resistance caused by gram-negative multidrug efflux pumps.
Nikaido H. Nikaido H. Clin Infect Dis. 1998 Aug;27 Suppl 1:S32-41. doi: 10.1086/514920. Clin Infect Dis. 1998. PMID: 9710669 Review.
Maltose transport system of Escherichia coli: an ABC-type transporter.
Nikaido H. Nikaido H. FEBS Lett. 1994 Jun 6;346(1):55-8. doi: 10.1016/0014-5793(94)00315-7. FEBS Lett. 1994. PMID: 8206159 Review.
PhoPQ-mediated regulation produces a more robust permeability barrier in the outer membrane of Salmonella enterica serovar typhimurium.
Murata T, Tseng W, Guina T, Miller SI, Nikaido H. Murata T, et al. J Bacteriol. 2007 Oct;189(20):7213-22. doi: 10.1128/JB.00973-07. Epub 2007 Aug 10. J Bacteriol. 2007. PMID: 17693506 Free PMC article.
Multidrug efflux pump AcrAB of Salmonella typhimurium excretes only those beta-lactam antibiotics containing lipophilic side chains.
Nikaido H, Basina M, Nguyen V, Rosenberg EY. Nikaido H, et al. J Bacteriol. 1998 Sep;180(17):4686-92. doi: 10.1128/JB.180.17.4686-4692.1998. J Bacteriol. 1998. PMID: 9721312 Free PMC article.
The exclusion of such compounds, exemplified by nafcillin, from cells of the wild-type S. typhimurium was previously interpreted as the result of poor diffusion across the outer membrane (H. Nikaido, Biochim. Biophys. Acta 433:118-132, 1976), but it is now recognize …
The exclusion of such compounds, exemplified by nafcillin, from cells of the wild-type S. typhimurium was previously interpreted as the resu …
Effect of site-directed mutations in multidrug efflux pump AcrB examined by quantitative efflux assays.
Kinana AD, Vargiu AV, Nikaido H. Kinana AD, et al. Among authors: nikaido h. Biochem Biophys Res Commun. 2016 Nov 25;480(4):552-557. doi: 10.1016/j.bbrc.2016.10.083. Epub 2016 Oct 24. Biochem Biophys Res Commun. 2016. PMID: 27789287 Free PMC article.
Aminoacyl β-naphthylamides as substrates and modulators of AcrB multidrug efflux pump.
Kinana AD, Vargiu AV, May T, Nikaido H. Kinana AD, et al. Among authors: nikaido h. Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):1405-10. doi: 10.1073/pnas.1525143113. Epub 2016 Jan 19. Proc Natl Acad Sci U S A. 2016. PMID: 26787896 Free PMC article.
The challenge of efflux-mediated antibiotic resistance in Gram-negative bacteria.
Li XZ, Plésiat P, Nikaido H. Li XZ, et al. Clin Microbiol Rev. 2015 Apr;28(2):337-418. doi: 10.1128/CMR.00117-14. Clin Microbiol Rev. 2015. PMID: 25788514 Free PMC article. Review.
Molecular mechanism of MBX2319 inhibition of Escherichia coli AcrB multidrug efflux pump and comparison with other inhibitors.
Vargiu AV, Ruggerone P, Opperman TJ, Nguyen ST, Nikaido H. Vargiu AV, et al. Antimicrob Agents Chemother. 2014 Oct;58(10):6224-34. doi: 10.1128/AAC.03283-14. Epub 2014 Aug 11. Antimicrob Agents Chemother. 2014. PMID: 25114133 Free PMC article.
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