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Indoxyl sulfate upregulates renal expression of ICAM-1 via production of ROS and activation of NF-κB and p53 in proximal tubular cells.
Shimizu H, Yisireyili M, Higashiyama Y, Nishijima F, Niwa T. Shimizu H, et al. Among authors: nishijima f. Life Sci. 2013 Feb 7;92(2):143-8. doi: 10.1016/j.lfs.2012.11.012. Epub 2012 Nov 28. Life Sci. 2013. PMID: 23201429
Senescence and dysfunction of proximal tubular cells are associated with activated p53 expression by indoxyl sulfate.
Shimizu H, Bolati D, Adijiang A, Enomoto A, Nishijima F, Dateki M, Niwa T. Shimizu H, et al. Among authors: nishijima f. Am J Physiol Cell Physiol. 2010 Nov;299(5):C1110-7. doi: 10.1152/ajpcell.00217.2010. Epub 2010 Aug 18. Am J Physiol Cell Physiol. 2010. PMID: 20720180
Indoxyl sulfate reduces superoxide scavenging activity in the kidneys of normal and uremic rats.
Owada S, Goto S, Bannai K, Hayashi H, Nishijima F, Niwa T. Owada S, et al. Among authors: nishijima f. Am J Nephrol. 2008;28(3):446-54. doi: 10.1159/000112823. Epub 2007 Dec 21. Am J Nephrol. 2008. PMID: 18160814
Indoxyl sulphate promotes aortic calcification with expression of osteoblast-specific proteins in hypertensive rats.
Adijiang A, Goto S, Uramoto S, Nishijima F, Niwa T. Adijiang A, et al. Among authors: nishijima f. Nephrol Dial Transplant. 2008 Jun;23(6):1892-901. doi: 10.1093/ndt/gfm861. Epub 2008 Mar 11. Nephrol Dial Transplant. 2008. PMID: 18334529
Indoxyl Sulfate Downregulates Mas Receptor via Aryl Hydrocarbon Receptor/Nuclear Factor-kappa B, and Induces Cell Proliferation and Tissue Factor Expression in Vascular Smooth Muscle Cells.
Ng HY, Bolati W, Lee CT, Chien YS, Yisireyili M, Saito S, Pei SN, Nishijima F, Niwa T. Ng HY, et al. Among authors: nishijima f. Nephron. 2016;133(3):205-12. doi: 10.1159/000447096. Epub 2016 Jun 25. Nephron. 2016. PMID: 27352232
Indoxyl sulfate induces IL-6 expression in vascular endothelial and smooth muscle cells through OAT3-mediated uptake and activation of AhR/NF-κB pathway.
Adelibieke Y, Yisireyili M, Ng HY, Saito S, Nishijima F, Niwa T. Adelibieke Y, et al. Among authors: nishijima f. Nephron Exp Nephrol. 2014;128(1-2):1-8. doi: 10.1159/000365217. Epub 2014 Nov 5. Nephron Exp Nephrol. 2014. PMID: 25376195
Indoxyl sulfate-induced activation of (pro)renin receptor promotes cell proliferation and tissue factor expression in vascular smooth muscle cells.
Yisireyili M, Saito S, Abudureyimu S, Adelibieke Y, Ng HY, Nishijima F, Takeshita K, Murohara T, Niwa T. Yisireyili M, et al. Among authors: nishijima f. PLoS One. 2014 Oct 24;9(10):e109268. doi: 10.1371/journal.pone.0109268. eCollection 2014. PLoS One. 2014. PMID: 25343458 Free PMC article.
Indoxyl sulfate downregulates expression of Mas receptor via OAT3/AhR/Stat3 pathway in proximal tubular cells.
Ng HY, Yisireyili M, Saito S, Lee CT, Adelibieke Y, Nishijima F, Niwa T. Ng HY, et al. Among authors: nishijima f. PLoS One. 2014 Mar 10;9(3):e91517. doi: 10.1371/journal.pone.0091517. eCollection 2014. PLoS One. 2014. PMID: 24614509 Free PMC article.
Indoxyl sulfate-induced activation of (pro)renin receptor is involved in expression of TGF-β1 and α-smooth muscle actin in proximal tubular cells.
Saito S, Shimizu H, Yisireyili M, Nishijima F, Enomoto A, Niwa T. Saito S, et al. Among authors: nishijima f. Endocrinology. 2014 May;155(5):1899-907. doi: 10.1210/en.2013-1937. Epub 2014 Mar 6. Endocrinology. 2014. PMID: 24601883
Indoxyl sulfate promotes cardiac fibrosis with enhanced oxidative stress in hypertensive rats.
Yisireyili M, Shimizu H, Saito S, Enomoto A, Nishijima F, Niwa T. Yisireyili M, et al. Among authors: nishijima f. Life Sci. 2013 Jul 10;92(24-26):1180-5. doi: 10.1016/j.lfs.2013.05.008. Epub 2013 May 21. Life Sci. 2013. PMID: 23702423
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