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A novel 1 beta-methylcarbapenem antibiotic, S-4661. Synthesis and structure-activity relationships of 2-(5-substituted pyrrolidin-3-ylthio)-1 beta-methylcarbapenems.
Iso Y, Irie T, Nishino Y, Motokawa K, Nishitani Y. Iso Y, et al. J Antibiot (Tokyo). 1996 Feb;49(2):199-209. doi: 10.7164/antibiotics.49.199. J Antibiot (Tokyo). 1996. PMID: 8621362
1-Oxacephem-based human chymase inhibitors: discovery of stable inhibitors in human plasma.
Aoyama Y, Uenaka M, Konoike T, Iso Y, Nishitani Y, Kanda A, Naya N, Nakajima M. Aoyama Y, et al. Bioorg Med Chem Lett. 2000 Nov 6;10(21):2403-6. doi: 10.1016/s0960-894x(00)00489-3. Bioorg Med Chem Lett. 2000. PMID: 11078188
Synthesis and structure-activity relationships of a new class of 1-oxacephem-based human chymase inhibitors.
Aoyama Y, Uenaka M, Konoike T, Iso Y, Nishitani Y, Kanda A, Naya N, Nakajima M. Aoyama Y, et al. Bioorg Med Chem Lett. 2000 Nov 6;10(21):2397-401. doi: 10.1016/s0960-894x(00)00488-1. Bioorg Med Chem Lett. 2000. PMID: 11078187
Synthesis and modification of a novel 1 beta-methyl carbapenem antibiotic, S-4661.
Iso Y, Irie T, Iwaki T, Kii M, Sendo Y, Motokawa K, Nishitani Y. Iso Y, et al. J Antibiot (Tokyo). 1996 May;49(5):478-84. doi: 10.7164/antibiotics.49.478. J Antibiot (Tokyo). 1996. PMID: 8682725
cis-Halovinylthioacetamido side chain, a new effective structural element for 7 beta-substitution in cephem and oxacephem antibiotics. I. 7 beta-cis-Chlorovinylthioacetamino-7 alpha-methoxy-1-oxacephems.
Nishitani Y, Aoki T, Yoshida T, Nagata W. Nishitani Y, et al. J Antibiot (Tokyo). 1988 Mar;41(3):316-31. doi: 10.7164/antibiotics.41.316. J Antibiot (Tokyo). 1988. PMID: 3366690
cis-Halovinylthioacetamido side chain, a new effective structural element for 7 beta-substitution in cephem and oxacephem antibiotics. II. 7 beta-cis-Fluorovinylthioacetamino-7 alpha-methoxy-1-oxacephems.
Nishitani Y, Aoki T, Konoike T, Takahashi H, Yamamoto S, Nishino Y, Yoshioka M, Tsuji T, Komatsu Y, Matsuura S, et al. Nishitani Y, et al. J Antibiot (Tokyo). 1988 Mar;41(3):332-42. doi: 10.7164/antibiotics.41.332. J Antibiot (Tokyo). 1988. PMID: 3366691
Preclinical in vivo antitumor efficacy of nedaplatin with gemcitabine against human lung cancer.
Matsumoto M, Takeda Y, Maki H, Hojo K, Wada T, Nishitani Y, Maekawa R, Yoshioka T. Matsumoto M, et al. Jpn J Cancer Res. 2001 Jan;92(1):51-8. doi: 10.1111/j.1349-7006.2001.tb01047.x. Jpn J Cancer Res. 2001. PMID: 11173544 Free PMC article.
Discovery of novel non-peptide thrombopoietin mimetic compounds that induce megakaryocytopoiesis.
Yamane N, Takahashi K, Tanaka Y, Kato K, Takayama M, Ohyabu N, Shiota T, Takenaka H, Yoshida Y, Hara S, Murashi T, Nakamura E, Nishitani Y, Ishizaki J, Yamane S, Nagata K, Koizumi K, Yutsudo T, Suzuki R, Itoh T, Takemoto H. Yamane N, et al. Biosci Rep. 2008 Oct;28(5):275-85. doi: 10.1042/BSR20080086. Biosci Rep. 2008. PMID: 18620546
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