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Introduction of histidine residues into avidin subunit interfaces allows pH-dependent regulation of quaternary structure and biotin binding.
Nordlund HR, Hytönen VP, Laitinen OH, Uotila ST, Niskanen EA, Savolainen J, Porkka E, Kulomaa MS. Nordlund HR, et al. Among authors: niskanen ea. FEBS Lett. 2003 Dec 18;555(3):449-54. doi: 10.1016/s0014-5793(03)01302-4. FEBS Lett. 2003. PMID: 14675754
Design and construction of highly stable, protease-resistant chimeric avidins.
Hytönen VP, Määttä JA, Nyholm TK, Livnah O, Eisenberg-Domovich Y, Hyre D, Nordlund HR, Hörhä J, Niskanen EA, Paldanius T, Kulomaa T, Porkka EJ, Stayton PS, Laitinen OH, Kulomaa MS. Hytönen VP, et al. Among authors: niskanen ea. J Biol Chem. 2005 Mar 18;280(11):10228-33. doi: 10.1074/jbc.M414196200. Epub 2005 Jan 13. J Biol Chem. 2005. PMID: 15649900
Controlling quaternary structure assembly: subunit interface engineering and crystal structure of dual chain avidin.
Hytönen VP, Hörhä J, Airenne TT, Niskanen EA, Helttunen KJ, Johnson MS, Salminen TA, Kulomaa MS, Nordlund HR. Hytönen VP, et al. Among authors: niskanen ea. J Mol Biol. 2006 Jun 23;359(5):1352-63. doi: 10.1016/j.jmb.2006.04.044. Epub 2006 May 6. J Mol Biol. 2006. PMID: 16787776
Structure and characterization of a novel chicken biotin-binding protein A (BBP-A).
Hytönen VP, Määttä JA, Niskanen EA, Huuskonen J, Helttunen KJ, Halling KK, Nordlund HR, Rissanen K, Johnson MS, Salminen TA, Kulomaa MS, Laitinen OH, Airenne TT. Hytönen VP, et al. Among authors: niskanen ea. BMC Struct Biol. 2007 Mar 7;7:8. doi: 10.1186/1472-6807-7-8. BMC Struct Biol. 2007. PMID: 17343730 Free PMC article.
Dynamics and interactions of parvoviral NS1 protein in the nucleus.
Ihalainen TO, Niskanen EA, Jylhävä J, Turpeinen T, Rinne J, Timonen J, Vihinen-Ranta M. Ihalainen TO, et al. Among authors: niskanen ea. Cell Microbiol. 2007 Aug;9(8):1946-59. doi: 10.1111/j.1462-5822.2007.00926.x. Epub 2007 Apr 5. Cell Microbiol. 2007. PMID: 17419720
Parvovirus induced alterations in nuclear architecture and dynamics.
Ihalainen TO, Niskanen EA, Jylhävä J, Paloheimo O, Dross N, Smolander H, Langowski J, Timonen J, Vihinen-Ranta M. Ihalainen TO, et al. Among authors: niskanen ea. PLoS One. 2009 Jun 17;4(6):e5948. doi: 10.1371/journal.pone.0005948. PLoS One. 2009. PMID: 19536327 Free PMC article.
Effect of ATP binding and hydrolysis on dynamics of canine parvovirus NS1.
Niskanen EA, Ihalainen TO, Kalliolinna O, Häkkinen MM, Vihinen-Ranta M. Niskanen EA, et al. J Virol. 2010 May;84(10):5391-403. doi: 10.1128/JVI.02221-09. Epub 2010 Mar 10. J Virol. 2010. PMID: 20219935 Free PMC article.
Coxsackievirus B3-induced cellular protrusions: structural characteristics and functional competence.
Paloheimo O, Ihalainen TO, Tauriainen S, Välilehto O, Kirjavainen S, Niskanen EA, Laakkonen JP, Hyöty H, Vihinen-Ranta M. Paloheimo O, et al. Among authors: niskanen ea. J Virol. 2011 Jul;85(13):6714-24. doi: 10.1128/JVI.00247-10. Epub 2011 Apr 27. J Virol. 2011. PMID: 21525342 Free PMC article.
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