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High fat diet worsens Alzheimer's disease-related behavioral abnormalities and neuropathology in APP/PS1 mice, but not by synergistically decreasing cerebral blood flow.
Bracko O, Vinarcsik LK, Cruz Hernández JC, Ruiz-Uribe NE, Haft-Javaherian M, Falkenhain K, Ramanauskaite EM, Ali M, Mohapatra A, Swallow MA, Njiru BN, Muse V, Michelucci PE, Nishimura N, Schaffer CB. Bracko O, et al. Among authors: njiru bn. Sci Rep. 2020 Jun 18;10(1):9884. doi: 10.1038/s41598-020-65908-y. Sci Rep. 2020. PMID: 32555372 Free PMC article.
Vascular oxidative stress causes neutrophil arrest in brain capillaries, leading to decreased cerebral blood flow and contributing to memory impairment in a mouse model of Alzheimer’s disease.
Ruiz-Uribe NE, Bracko O, Swallow M, Omurzakov A, Dash S, Uchida H, Xiang D, Haft-Javaherian M, Falkenhain K, Lamont ME, Ali M, Njiru BN, Chang HY, Tan AY, Xiang JZ, Iadecola C, Park L, Sanchez T, Nishimura N, Schaffer CB. Ruiz-Uribe NE, et al. Among authors: njiru bn. bioRxiv [Preprint]. 2023 Feb 15:2023.02.15.528710. doi: 10.1101/2023.02.15.528710. bioRxiv. 2023. PMID: 36824768 Free PMC article. Preprint.
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