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Mutations conferring resistance to SCH6, a novel hepatitis C virus NS3/4A protease inhibitor. Reduced RNA replication fitness and partial rescue by second-site mutations.
Yi M, Tong X, Skelton A, Chase R, Chen T, Prongay A, Bogen SL, Saksena AK, Njoroge FG, Veselenak RL, Pyles RB, Bourne N, Malcolm BA, Lemon SM. Yi M, et al. Among authors: njoroge fg. J Biol Chem. 2006 Mar 24;281(12):8205-15. doi: 10.1074/jbc.M510246200. Epub 2005 Dec 13. J Biol Chem. 2006. PMID: 16352601
Macrocyclic inhibitors of HCV NS3 protease.
Venkatraman S, Njoroge FG. Venkatraman S, et al. Among authors: njoroge fg. Expert Opin Ther Pat. 2009 Sep;19(9):1277-303. doi: 10.1517/13543770903044994. Expert Opin Ther Pat. 2009. PMID: 19563268 Review.
Key steps in the structure-based optimization of the hepatitis C virus NS3/4A protease inhibitor SCH503034.
Madison V, Prongay AJ, Guo Z, Yao N, Pichardo J, Fischmann T, Strickland C, Myers J Jr, Weber PC, Beyer BM, Ingram R, Hong Z, Prosise WW, Ramanathan L, Taremi SS, Yarosh-Tomaine T, Zhang R, Senior M, Yang RS, Malcolm B, Arasappan A, Bennett F, Bogen SL, Chen K, Jao E, Liu YT, Lovey RG, Saksena AK, Venkatraman S, Girijavallabhan V, Njoroge FG. Madison V, et al. Among authors: njoroge fg. J Synchrotron Radiat. 2008 May;15(Pt 3):204-7. doi: 10.1107/S0909049507064229. Epub 2008 Apr 18. J Synchrotron Radiat. 2008. PMID: 18421139 Free PMC article.
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