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Crystal structures of the Streptomyces coelicolor TetR-like protein ActR alone and in complex with actinorhodin or the actinorhodin biosynthetic precursor (S)-DNPA.
Willems AR, Tahlan K, Taguchi T, Zhang K, Lee ZZ, Ichinose K, Junop MS, Nodwell JR. Willems AR, et al. J Mol Biol. 2008 Mar 7;376(5):1377-87. doi: 10.1016/j.jmb.2007.12.061. Epub 2008 Jan 4. J Mol Biol. 2008. PMID: 18207163
Activity-Independent Discovery of Secondary Metabolites Using Chemical Elicitation and Cheminformatic Inference.
Pimentel-Elardo SM, Sørensen D, Ho L, Ziko M, Bueler SA, Lu S, Tao J, Moser A, Lee R, Agard D, Fairn G, Rubinstein JL, Shoichet BK, Nodwell JR. Pimentel-Elardo SM, et al. ACS Chem Biol. 2015 Nov 20;10(11):2616-23. doi: 10.1021/acschembio.5b00612. Epub 2015 Sep 18. ACS Chem Biol. 2015. PMID: 26352211 Free PMC article.
Better chemistry through regulation.
Nodwell JR, Cuthbertson L. Nodwell JR, et al. Chem Biol. 2011 Dec 23;18(12):1515-6. doi: 10.1016/j.chembiol.2011.12.001. Chem Biol. 2011. PMID: 22195551
The SapB morphogen is a lantibiotic-like peptide derived from the product of the developmental gene ramS in Streptomyces coelicolor.
Kodani S, Hudson ME, Durrant MC, Buttner MJ, Nodwell JR, Willey JM. Kodani S, et al. Proc Natl Acad Sci U S A. 2004 Aug 3;101(31):11448-53. doi: 10.1073/pnas.0404220101. Epub 2004 Jul 26. Proc Natl Acad Sci U S A. 2004. PMID: 15277670 Free PMC article.
The TetR family of regulators.
Cuthbertson L, Nodwell JR. Cuthbertson L, et al. Microbiol Mol Biol Rev. 2013 Sep;77(3):440-75. doi: 10.1128/MMBR.00018-13. Microbiol Mol Biol Rev. 2013. PMID: 24006471 Free PMC article. Review.
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