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IL-6R/STAT3-signaling in keratinocytes rather than T cells induces psoriasis-like dermatitis in mice.
Ravipati A, Nolan S, Alphonse M, Dikeman D, Youn C, Wang Y, Orlando N, Patrick G, Lee S, Ortines RV, Liu H, Miller RJ, Dillen CA, Marchitto M, Cai SS, Miller LS, Archer NK. Ravipati A, et al. Among authors: nolan s. J Invest Dermatol. 2021 Oct 6:S0022-202X(21)02291-0. doi: 10.1016/j.jid.2021.09.012. Online ahead of print. J Invest Dermatol. 2021. PMID: 34626614
Optimization of TopoIV Potency, ADMET Properties, and hERG Inhibition of 5-Amino-1,3-dioxane-Linked Novel Bacterial Topoisomerase Inhibitors: Identification of a Lead with In Vivo Efficacy against MRSA.
Lu Y, Vibhute S, Li L, Okumu A, Ratigan SC, Nolan S, Papa JL, Mann CA, English A, Chen A, Seffernick JT, Koci B, Duncan LR, Roth B, Cummings JE, Slayden RA, Lindert S, McElroy CA, Wozniak DJ, Yalowich J, Mitton-Fry MJ. Lu Y, et al. Among authors: nolan s. J Med Chem. 2021 Oct 6. doi: 10.1021/acs.jmedchem.1c01250. Online ahead of print. J Med Chem. 2021. PMID: 34614347
Discovery of the Oxadiazine FRM-024: A Potent CNS-Penetrant Gamma Secretase Modulator.
Bursavich MG, Harrison BA, Acharya R, Costa DE, Freeman EA, Hrdlicka LA, Jin H, Kapadnis S, Moffit JS, Murphy D, Nolan SJ, Patzke H, Tang C, Van Voorhies HE, Wen M, Koenig G, Blain JF, Burnett DA. Bursavich MG, et al. Among authors: nolan sj. J Med Chem. 2021 Oct 14;64(19):14426-14447. doi: 10.1021/acs.jmedchem.1c00904. Epub 2021 Sep 22. J Med Chem. 2021. PMID: 34550687
A vitamin D enriched diet attenuates sex-specific behavioral deficits, increases the lifespan, but does not rescue bone abnormalities in a mouse model of cortical dysplasia.
Womble PD, Hodges SL, Nolan SO, Binder MS, Holley AJ, Herrera R, Senger S, Kwok E, Narviaz DA, Faust A, Hernandez-Zegada CJ, Kwon RY, Lugo JN. Womble PD, et al. Among authors: nolan so. Epilepsy Behav. 2021 Sep 9;124:108297. doi: 10.1016/j.yebeh.2021.108297. Online ahead of print. Epilepsy Behav. 2021. PMID: 34509882
Quantitative microbial human exposure model for faecal indicator bacteria and risk assessment of pathogenic Escherichia coli in surface runoff following application of dairy cattle slurry and co-digestate to grassland.
Nag R, Nolan S, O'Flaherty V, Fenton O, Richards KG, Markey BK, Whyte P, Bolton D, Cummins E. Nag R, et al. Among authors: nolan s. J Environ Manage. 2021 Dec 1;299:113627. doi: 10.1016/j.jenvman.2021.113627. Epub 2021 Aug 28. J Environ Manage. 2021. PMID: 34467857 Free article.
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