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Steady-state pharmacokinetics of corticosteroid delivery from glucuronide prodrugs in normal and colitic rats.
Nolen HW 3rd, Fedorak RN, Friend DR. Nolen HW 3rd, et al. Biopharm Drug Dispos. 1997 Nov;18(8):681-95. doi: 10.1002/(sici)1099-081x(199711)18:8<681::aid-bdd56>3.0.co;2-a. Biopharm Drug Dispos. 1997. PMID: 9373725
Colonic delivery of dexamethasone from a prodrug accelerates healing of colitis in rats without adrenal suppression.
Fedorak RN, Haeberlin B, Empey LR, Cui N, Nolen H 3rd, Jewell LD, Friend DR. Fedorak RN, et al. Among authors: nolen h 3rd. Gastroenterology. 1995 Jun;108(6):1688-99. doi: 10.1016/0016-5085(95)90130-2. Gastroenterology. 1995. PMID: 7768373
Budesonide-beta-D-glucuronide: a potential prodrug for treatment of ulcerative colitis.
Nolen H 3rd, Fedorak RN, Friend DR. Nolen H 3rd, et al. J Pharm Sci. 1995 Jun;84(6):677-81. doi: 10.1002/jps.2600840603. J Pharm Sci. 1995. PMID: 7562403 Clinical Trial.
Menthol-beta-D-glucuronide: a potential prodrug for treatment of the irritable bowel syndrome.
Nolen HW 3rd, Friend DR. Nolen HW 3rd, et al. Pharm Res. 1994 Dec;11(12):1707-11. doi: 10.1023/a:1018950930134. Pharm Res. 1994. PMID: 7899232
In vitro evaluation of dexamethasone-beta-D-glucuronide for colon-specific drug delivery.
Haeberlin B, Rubas W, Nolen HW 3rd, Friend DR. Haeberlin B, et al. Among authors: nolen hw 3rd. Pharm Res. 1993 Nov;10(11):1553-62. doi: 10.1023/a:1018956232628. Pharm Res. 1993. PMID: 8290467
Combined chromatographic-isotopic dilution analysis of fecapentaenes in human feces.
Peters JH, Nolen HW 3rd, Gordon GR, Bradford WW 3rd, Bupp JE, Reist EJ. Peters JH, et al. Among authors: nolen hw 3rd. J Chromatogr. 1989 Mar 24;488(2):301-13. doi: 10.1016/s0378-4347(00)82955-2. J Chromatogr. 1989. PMID: 2663902
Quaternary salts of 2-[(hydroxyimino)methyl]imidazole. 2. Preparation and in vitro and in vivo evaluation of 1-(alkoxymethyl)-2-[(hydroxyimino)methyl]-3-methylimida zolium halides for reactivation of organophosphorus-inhibited acetylcholinesterases.
Bedford CD, Harris RN 3rd, Howd RA, Goff DA, Koolpe GA, Petesch M, Miller A, Nolen HW 3rd, Musallam HA, Pick RO, et al. Bedford CD, et al. Among authors: nolen hw 3rd. J Med Chem. 1989 Feb;32(2):493-503. doi: 10.1021/jm00122a034. J Med Chem. 1989. PMID: 2913310
Facile exchange of the cyano group in highly potent anticancer cyanomorpholinyl anthracyclines.
Peters JH, Gordon GR, Nolen HW 3rd, Tracy M, Thomas DW. Peters JH, et al. Among authors: nolen hw 3rd. Biochem Pharmacol. 1988 Jan 15;37(2):357-61. doi: 10.1016/0006-2952(88)90742-3. Biochem Pharmacol. 1988. PMID: 3422560 No abstract available.
Nonquaternary cholinesterase reactivators. 3. 3(5)-Substituted 1,2,4-oxadiazol-5(3)-aldoximes and 1,2,4-oxadiazole-5(3)-thiocarbohydroximates as reactivators of organophosphonate-inhibited eel and human acetylcholinesterase in vitro.
Bedford CD, Howd RA, Dailey OD, Miller A, Nolen HW 3rd, Kenley RA, Kern JR, Winterle JS. Bedford CD, et al. Among authors: nolen hw 3rd. J Med Chem. 1986 Nov;29(11):2174-83. doi: 10.1021/jm00161a008. J Med Chem. 1986. PMID: 3783578
Nonquaternary cholinesterase reactivators. 4. Dialkylaminoalkyl thioesters of alpha-keto thiohydroximic acids as reactivators of ethyl methylphosphonyl- and 1,2,2-trimethylpropyl methylphosphonyl-acetylcholinesterase in vitro.
Bedford CD, Miura M, Bottaro JC, Howd RA, Nolen HW 3rd. Bedford CD, et al. Among authors: nolen hw 3rd. J Med Chem. 1986 Sep;29(9):1689-96. doi: 10.1021/jm00159a021. J Med Chem. 1986. PMID: 3746817
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