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NAFLD and increased risk of cardiovascular disease: clinical associations, pathophysiological mechanisms and pharmacological implications.
Targher G, Byrne CD, Tilg H. Targher G, et al. Gut. 2020 Sep;69(9):1691-1705. doi: 10.1136/gutjnl-2020-320622. Epub 2020 Apr 22. Gut. 2020. PMID: 32321858 Review.
Non-alcoholic fatty liver disease (NAFLD) is a public health problem, affecting up to a third of the world's adult population. ...This narrative review provides an overview of the literature on: (1) the evidence for an association between NAFLD
Non-alcoholic fatty liver disease (NAFLD) is a public health problem, affecting up to a third of the worl
Non-alcoholic fatty liver disease and cardiovascular risk: Pathophysiological mechanisms and implications.
Francque SM, van der Graaff D, Kwanten WJ. Francque SM, et al. J Hepatol. 2016 Aug;65(2):425-43. doi: 10.1016/j.jhep.2016.04.005. Epub 2016 Jun 1. J Hepatol. 2016. PMID: 27091791 Review.
Non-alcoholic fatty liver disease (NAFLD) has become one of the most frequent chronic liver diseases in the Western society and its prevalence is likely to rise even further. An increasing body of evidence shows that NAFLD is not only a p
Non-alcoholic fatty liver disease (NAFLD) has become one of the most frequent chronic liver diseas
Partial MCT1 invalidation protects against diet-induced non-alcoholic fatty liver disease and the associated brain dysfunction.
Hadjihambi A, Konstantinou C, Klohs J, Monsorno K, Le Guennec A, Donnelly C, Cox IJ, Kusumbe A, Hosford PS, Soffientini U, Lecca S, Mameli M, Jalan R, Paolicelli RC, Pellerin L. Hadjihambi A, et al. J Hepatol. 2023 Jan;78(1):180-190. doi: 10.1016/j.jhep.2022.08.008. Epub 2022 Aug 19. J Hepatol. 2023. PMID: 35995127 Free article.
BACKGROUND & AIMS: Non-alcoholic fatty liver disease (NAFLD) has been associated with mild cerebral dysfunction and cognitive decline, although the exact pathophysiological mechanism remains ambiguous. ...IMPACT AND IMPLICAT
BACKGROUND & AIMS: Non-alcoholic fatty liver disease (NAFLD) has been associated with mild cerebral d …
Heterogeneity of non-alcoholic fatty liver disease (NAFLD): Implication for cardiovascular risk stratification.
Baratta F, D'Erasmo L, Bini S, Pastori D, Angelico F, Del Ben M, Arca M, Di Costanzo A. Baratta F, et al. Atherosclerosis. 2022 Sep;357:51-59. doi: 10.1016/j.atherosclerosis.2022.08.011. Epub 2022 Aug 20. Atherosclerosis. 2022. PMID: 36058083 Review.
NAFLD is currently considered the most common liver disease worldwide and mounting data support its strong link with atherosclerotic cardiovascular disease (ASCVD). ...However, NAFLD is encountered also in subjects without insulin resistance and metabo …
NAFLD is currently considered the most common liver disease worldwide and mounting data support its strong link with atheroscl …
Type 2 Diabetes in Non-Alcoholic Fatty Liver Disease and Hepatitis C Virus Infection--Liver: The "Musketeer" in the Spotlight.
Ballestri S, Nascimbeni F, Romagnoli D, Baldelli E, Targher G, Lonardo A. Ballestri S, et al. Int J Mol Sci. 2016 Mar 9;17(3):355. doi: 10.3390/ijms17030355. Int J Mol Sci. 2016. PMID: 27005620 Free PMC article. Review.
The pathogenesis of type 2 diabetes (T2D) involves chronic hyperinsulinemia due to systemic and hepatic insulin resistance (IR), which if uncorrected, will lead to progressive pancreatic beta cell failure in predisposed individuals. Non-alcoholic fatty liv
The pathogenesis of type 2 diabetes (T2D) involves chronic hyperinsulinemia due to systemic and hepatic insulin resistance (IR), which if un …
Fatty liver is associated with an increased risk of diabetes and cardiovascular disease - Evidence from three different disease models: NAFLD, HCV and HIV.
Lonardo A, Ballestri S, Guaraldi G, Nascimbeni F, Romagnoli D, Zona S, Targher G. Lonardo A, et al. World J Gastroenterol. 2016 Nov 28;22(44):9674-9693. doi: 10.3748/wjg.v22.i44.9674. World J Gastroenterol. 2016. PMID: 27956792 Free PMC article. Review.
Fatty liver, which frequently coexists with necro-inflammatory and fibrotic changes, may occur in the setting of nonalcoholic fatty liver disease (NAFLD) and chronic infections due to either hepatitis C virus (HCV) or human immunodeficiency viru
Fatty liver, which frequently coexists with necro-inflammatory and fibrotic changes, may occur in the setting of nonalcoholic
Characterizing skeletal muscle dysfunction in women with polycystic ovary syndrome.
McDonnell T, Cussen L, McIlroy M, O'Reilly MW. McDonnell T, et al. Ther Adv Endocrinol Metab. 2022 Jul 18;13:20420188221113140. doi: 10.1177/20420188221113140. eCollection 2022. Ther Adv Endocrinol Metab. 2022. PMID: 35874313 Free PMC article. Review.
It has traditionally been viewed as a primarily reproductive disorder; however, it is increasingly recognized as a lifelong metabolic disease. Women with PCOS are at increased risk of insulin resistance (IR), type 2 diabetes mellitus, non-alcoholic
It has traditionally been viewed as a primarily reproductive disorder; however, it is increasingly recognized as a lifelong metabolic dis
Cholesterol Homeostasis: An In Silico Investigation into How Aging Disrupts Its Key Hepatic Regulatory Mechanisms.
Morgan AE, Mc Auley MT. Morgan AE, et al. Biology (Basel). 2020 Sep 30;9(10):314. doi: 10.3390/biology9100314. Biology (Basel). 2020. PMID: 33007859 Free PMC article.
The dysregulation of intracellular cholesterol homeostasis is associated with several age-related diseases, most notably cardiovascular disease (CVD). Research in this area has benefitted from using computational modelling to study the inherent complexity associated …
The dysregulation of intracellular cholesterol homeostasis is associated with several age-related diseases, most notably cardiovascular