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Non-animal methods to predict skin sensitization (II): an assessment of defined approaches (*).
Kleinstreuer NC, Hoffmann S, Alépée N, Allen D, Ashikaga T, Casey W, Clouet E, Cluzel M, Desprez B, Gellatly N, Göbel C, Kern PS, Klaric M, Kühnl J, Martinozzi-Teissier S, Mewes K, Miyazawa M, Strickland J, van Vliet E, Zang Q, Petersohn D. Kleinstreuer NC, et al. Crit Rev Toxicol. 2018 May;48(5):359-374. doi: 10.1080/10408444.2018.1429386. Epub 2018 Feb 23. Crit Rev Toxicol. 2018. PMID: 29474122 Free PMC article. Review.
Skin sensitization is a toxicity endpoint of widespread concern, for which the mechanistic understanding and concurrent necessity for non-animal testing approaches have evolved to a critical juncture, with many available options for predictin
Skin sensitization is a toxicity endpoint of widespread concern, for which the mechanistic understanding and concurrent necess
Replacing the refinement for skin sensitization testing: Considerations to the implementation of adverse outcome pathway (AOP)-based defined approaches (DA) in OECD guidelines.
Kolle SN, Landsiedel R, Natsch A. Kolle SN, et al. Regul Toxicol Pharmacol. 2020 Aug;115:104713. doi: 10.1016/j.yrtph.2020.104713. Epub 2020 Jun 17. Regul Toxicol Pharmacol. 2020. PMID: 32562760
While single non-animal methods have been adopted in OECD test guidelines, combinations of methods (so called defined approaches, DA) are not. Hardly any animal study can be replaced by a single non-animal method
While single non-animal methods have been adopted in OECD test guidelines, combinations of methods (so called …