Nonsynonymous single-nucleotide polymorphisms in the G6PC2 gene affect protein expression, enzyme activity, and fasting blood glucose.
J Biol Chem. 2022.
PMID: 34954144
Free PMC article.
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Nonsynonymous single-nucleotide polymorphisms in the G6PC2 gene affect protein expression, enzyme activity, and fasting blood glucose.
Overway EM, Bosma KJ, Claxton DP, Oeser JK, Singh K, Breidenbach LB, Mchaourab HS, Davis LK, O'Brien RM.
Overway EM, et al.
J Biol Chem. 2022 Feb;298(2):101534. doi: 10.1016/j.jbc.2021.101534. Epub 2021 Dec 23.
J Biol Chem. 2022.
PMID: 34954144
Free PMC article.
G6PC2 encodes a glucose-6-phosphatase (G6Pase) catalytic subunit that modulates the sensitivity of insulin secretion to glucose and thereby regulates fasting blood glucose (FBG). A common single-nucleotide polymorphism …
G6PC2 encodes a glucose-6-phosphatase (G6Pase) catalytic subunit that modulates the sensitivity of insulin secretion to glu …
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Functional Analysis of Mouse G6pc1 Mutations Using a Novel In Situ Assay for Glucose-6-Phosphatase Activity and the Effect of Mutations in Conserved Human G6PC1/G6PC2 Amino Acids on G6PC2 Protein Expression.
Boortz KA, Syring KE, Pound LD, Wang Y, Oeser JK, O'Brien RM.
Boortz KA, et al.
PLoS One. 2016 Sep 9;11(9):e0162439. doi: 10.1371/journal.pone.0162439. eCollection 2016.
PLoS One. 2016.
PMID: 27611587
Free PMC article.
Single nucleotide polymorphisms (SNPs) in G6PC2 are the most important common determinants of variations in FBG in humans. ...Using a novel in situ functional assay for glucose-6-phosphatase activity we demonstrate that the amino acid cha …
Single nucleotide polymorphisms (SNPs) in G6PC2 are the most important common determinants of variations in FBG …
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