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A shift in paradigm towards human biology-based systems for cholestatic-liver diseases.
Noor F. Noor F. J Physiol. 2015 Dec 1;593(23):5043-55. doi: 10.1113/JP271124. Epub 2015 Nov 4. J Physiol. 2015. PMID: 26417843 Free PMC article. Review.
Towards a 21st-century roadmap for biomedical research and drug discovery: consensus report and recommendations.
Langley GR, Adcock IM, Busquet F, Crofton KM, Csernok E, Giese C, Heinonen T, Herrmann K, Hofmann-Apitius M, Landesmann B, Marshall LJ, McIvor E, Muotri AR, Noor F, Schutte K, Seidle T, van de Stolpe A, Van Esch H, Willett C, Woszczek G. Langley GR, et al. Among authors: noor f. Drug Discov Today. 2017 Feb;22(2):327-339. doi: 10.1016/j.drudis.2016.10.011. Epub 2016 Oct 29. Drug Discov Today. 2017. PMID: 27989722 Review.
3D organotypic HepaRG cultures as in vitro model for acute and repeated dose toxicity studies.
Mueller D, Krämer L, Hoffmann E, Klein S, Noor F. Mueller D, et al. Among authors: noor f. Toxicol In Vitro. 2014 Feb;28(1):104-12. doi: 10.1016/j.tiv.2013.06.024. Epub 2013 Jul 9. Toxicol In Vitro. 2014. PMID: 23850736
Novel human hepatic organoid model enables testing of drug-induced liver fibrosis in vitro.
Leite SB, Roosens T, El Taghdouini A, Mannaerts I, Smout AJ, Najimi M, Sokal E, Noor F, Chesne C, van Grunsven LA. Leite SB, et al. Among authors: noor f. Biomaterials. 2016 Feb;78:1-10. doi: 10.1016/j.biomaterials.2015.11.026. Epub 2015 Nov 17. Biomaterials. 2016. PMID: 26618472
In Silico Modeling for the Prediction of Dose and Pathway-Related Adverse Effects in Humans From In Vitro Repeated-Dose Studies.
Klein S, Maggioni S, Bucher J, Mueller D, Niklas J, Shevchenko V, Mauch K, Heinzle E, Noor F. Klein S, et al. Among authors: noor f. Toxicol Sci. 2016 Jan;149(1):55-66. doi: 10.1093/toxsci/kfv218. Epub 2015 Sep 29. Toxicol Sci. 2016. PMID: 26420750
Accessing 3D microtissue metabolism: Lactate and oxygen monitoring in hepatocyte spheroids.
Weltin A, Hammer S, Noor F, Kaminski Y, Kieninger J, Urban GA. Weltin A, et al. Among authors: noor f. Biosens Bioelectron. 2017 Jan 15;87:941-948. doi: 10.1016/j.bios.2016.07.094. Epub 2016 Jul 28. Biosens Bioelectron. 2017. PMID: 27665516
Metabolic fate of desomorphine elucidated using rat urine, pooled human liver preparations, and human hepatocyte cultures as well as its detectability using standard urine screening approaches.
Richter LH, Kaminski YR, Noor F, Meyer MR, Maurer HH. Richter LH, et al. Among authors: noor f. Anal Bioanal Chem. 2016 Sep;408(23):6283-94. doi: 10.1007/s00216-016-9740-4. Epub 2016 Jul 2. Anal Bioanal Chem. 2016. PMID: 27372715
Long-term maintenance of HepaRG cells in serum-free conditions and application in a repeated dose study.
Klein S, Mueller D, Schevchenko V, Noor F. Klein S, et al. Among authors: noor f. J Appl Toxicol. 2014 Oct;34(10):1078-86. doi: 10.1002/jat.2929. Epub 2013 Sep 30. J Appl Toxicol. 2014. PMID: 24114766
Real-time in situ viability assessment in a 3D bioreactor with liver cells using resazurin assay.
Mueller D, Tascher G, Damm G, Nüssler AK, Heinzle E, Noor F. Mueller D, et al. Among authors: noor f. Cytotechnology. 2013 Mar;65(2):297-305. doi: 10.1007/s10616-012-9486-6. Epub 2012 Jul 25. Cytotechnology. 2013. PMID: 22828753 Free PMC article.
Biotransformation of diclofenac and effects on the metabolome of primary human hepatocytes upon repeated dose exposure.
Mueller D, Müller-Vieira U, Biemel KM, Tascher G, Nüssler AK, Noor F. Mueller D, et al. Among authors: noor f. Eur J Pharm Sci. 2012 Apr 11;45(5):716-24. doi: 10.1016/j.ejps.2012.01.014. Epub 2012 Feb 4. Eur J Pharm Sci. 2012. PMID: 22330146
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