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Endogenous glutamine production in critically ill patients: the effect of exogenous glutamine supplementation.
Mori M, Rooyackers O, Smedberg M, Tjäder I, Norberg A, Wernerman J. Mori M, et al. Among authors: norberg a. Crit Care. 2014 Apr 14;18(2):R72. doi: 10.1186/cc13829. Crit Care. 2014. PMID: 24731231 Free PMC article. Clinical Trial.
Recently a technique employing a bolus injection of isotopically labeled glutamine was introduced, with the potential to allow for multiple assessments of the glutamine Ra over time in critically ill patients, who may not be as metabolically stable as healthy indivi …
Recently a technique employing a bolus injection of isotopically labeled glutamine was introduced, with the potential to allow …
Elimination kinetics of L-alanyl-L-glutamine in ICU patients.
Berg A, Rooyackers O, Norberg A, Wernerman J. Berg A, et al. Among authors: norberg a. Amino Acids. 2005 Nov;29(3):221-8. doi: 10.1007/s00726-005-0230-9. Epub 2005 Aug 1. Amino Acids. 2005. PMID: 16049639 Clinical Trial.
A randomised, double blind, placebo-controlled study was performed giving 0.5 g x kg(-1) x day(-1) of undiluted alanyl-glutamine (20%) or saline in a peripheral vein during 4 hours in ICU patients (n = 20). During the infusion period a steady state in plasma
A randomised, double blind, placebo-controlled study was performed giving 0.5 g x kg(-1) x day(-1) of undiluted alanyl-glutamine (20%
Glutamine kinetics during intravenous glutamine supplementation in ICU patients on continuous renal replacement therapy.
Berg A, Norberg A, Martling CR, Gamrin L, Rooyackers O, Wernerman J. Berg A, et al. Among authors: norberg a. Intensive Care Med. 2007 Apr;33(4):660-6. doi: 10.1007/s00134-007-0547-9. Epub 2007 Feb 22. Intensive Care Med. 2007. PMID: 17318498 Clinical Trial.
DESIGN AND PATIENTS: In a pragmatic clinical study 12 patients without urine production receiving CRRT were prospectively randomized in a cross-over design to receive glutamine intravenously for 20 h before placebo or placebo before glutamine on two consecutive days …
DESIGN AND PATIENTS: In a pragmatic clinical study 12 patients without urine production receiving CRRT were prospectively randomized …
The pattern of amino acid exchange across the brain is unaffected by intravenous glutamine supplementation in head trauma patients.
Berg A, Bellander BM, Wanecek M, Norberg A, Ungerstedt U, Rooyackers O, Wernerman J. Berg A, et al. Among authors: norberg a. Clin Nutr. 2008 Dec;27(6):816-21. doi: 10.1016/j.clnu.2008.06.006. Epub 2008 Jul 22. Clin Nutr. 2008. PMID: 18649974 Clinical Trial.
The arterio-venous (a-v) concentration differences over the brain were calculated to be -49+/-26 and -27+/-14 micromol/L during the treatment and control periods respectively, showing a continuous release of glutamine (p<0.0001). On the other hand, the a-v …
The arterio-venous (a-v) concentration differences over the brain were calculated to be -49+/-26 and -27+/-14 micromol/L during the t …
Glutamine and glutathione at ICU admission in relation to outcome.
Rodas PC, Rooyackers O, Hebert C, Norberg Å, Wernerman J. Rodas PC, et al. Among authors: norberg a. Clin Sci (Lond). 2012 Jun;122(12):591-7. doi: 10.1042/CS20110520. Clin Sci (Lond). 2012. PMID: 22248298 Free PMC article.
The admission plasma glutamine concentrations were totally independent of the conventional risk scoring at admittance, and a subnormal concentration was an independent predictor of mortality. In addition, glutathione redox status was also an independent mortality predictor …
The admission plasma glutamine concentrations were totally independent of the conventional risk scoring at admittance, and a subnorma …
Whole body protein turnover in critically ill patients with multiple organ failure.
Rooyackers O, Kouchek-Zadeh R, Tjäder I, Norberg Å, Klaude M, Wernerman J. Rooyackers O, et al. Among authors: norberg a. Clin Nutr. 2015 Feb;34(1):95-100. doi: 10.1016/j.clnu.2014.01.020. Epub 2014 Feb 5. Clin Nutr. 2015. PMID: 24556361

METHODS: As a reference group, healthy volunteers (n = 8) were studied in the postabsorptive state and during parenteral nutrition delivery. ...For phenylalanine this change was attributable to an increased protein synthesis (P < 0.0001), while for leucine the change wa

METHODS: As a reference group, healthy volunteers (n = 8) were studied in the postabsorptive state and during parenteral nutrition de …
A tracer bolus method for investigating glutamine kinetics in humans.
Mori M, Smedberg M, Klaude M, Tjäder I, Norberg A, Rooyackers O, Wernerman J. Mori M, et al. Among authors: norberg a. PLoS One. 2014 May 8;9(5):e96601. doi: 10.1371/journal.pone.0096601. eCollection 2014. PLoS One. 2014. PMID: 24810895 Free PMC article. Clinical Trial.
Endogenous glutamine production can be measured by continuous infusion of a glutamine tracer, which necessitates a minimum measurement time period. ...Healthy volunteers received a bolus injection of [1-13C] glutamine, and blood was collected from the radial …
Endogenous glutamine production can be measured by continuous infusion of a glutamine tracer, which necessitates a minimum mea …
Plasma glutamine concentration after intensive care unit discharge: an observational study.
Smedberg M, Grass JN, Pettersson L, Norberg Å, Rooyackers O, Wernerman J. Smedberg M, et al. Among authors: norberg a. Crit Care. 2014 Dec 9;18(6):677. doi: 10.1186/s13054-014-0677-8. Crit Care. 2014. PMID: 25488701 Free PMC article.
In the recent Scandinavian Glutamine Trial, a survival advantage was seen with glutamine supplementation as long as patients stayed in the ICU. It was therefore hypothesized that the glutamine level may drop at ICU discharge, indicative of a sustained glutamine defi …
In the recent Scandinavian Glutamine Trial, a survival advantage was seen with glutamine supplementation as long as patients stayed i …
Plasma Glutamine Concentrations in Liver Failure.
Helling G, Wahlin S, Smedberg M, Pettersson L, Tjäder I, Norberg Å, Rooyackers O, Wernerman J. Helling G, et al. Among authors: norberg a. PLoS One. 2016 Mar 3;11(3):e0150440. doi: 10.1371/journal.pone.0150440. eCollection 2016. PLoS One. 2016. PMID: 26938452 Free PMC article.
CONCLUSION: Liver failure, regardless of severity and course of illness, may be associated with a high plasma glutamine concentration. Further studies are needed to understand whether high glutamine levels should be regarded as a biomarker or as a contributor …
CONCLUSION: Liver failure, regardless of severity and course of illness, may be associated with a high plasma glutamine concentration …
Measuring energy expenditure in the intensive care unit: a comparison of indirect calorimetry by E-sCOVX and Quark RMR with Deltatrac II in mechanically ventilated critically ill patients.
Rehal MS, Fiskaare E, Tjäder I, Norberg Å, Rooyackers O, Wernerman J. Rehal MS, et al. Among authors: norberg a. Crit Care. 2016 Mar 5;20:54. doi: 10.1186/s13054-016-1232-6. Crit Care. 2016. PMID: 26951095 Free PMC article.
The aim of this study was to validate two modern devices (E-sCOVX and Quark RMR) against a reference method (Deltatrac II). METHOD: Measurements of VO2/VCO2 with the test and reference devices were performed simultaneously over a 20-min period in mechanically ventil …
The aim of this study was to validate two modern devices (E-sCOVX and Quark RMR) against a reference method (Deltatrac II). METHOD: M …
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