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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1947 3
1948 2
1952 1
1961 1
1963 2
1964 1
1968 1
1969 3
1970 3
1972 1
1975 1
1976 6
1977 1
1978 5
1979 3
1980 16
1981 13
1982 28
1983 52
1984 79
1985 97
1986 108
1987 122
1988 116
1989 117
1990 124
1991 128
1992 112
1993 102
1994 83
1995 89
1996 85
1997 90
1998 92
1999 65
2000 60
2001 57
2002 61
2003 45
2004 43
2005 46
2006 45
2007 56
2008 47
2009 39
2010 43
2011 50
2012 42
2013 28
2014 25
2015 32
2016 30
2017 26
2018 16
2019 21
2020 19
2021 21
2022 26
2023 4
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2,550 results
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Nordihydroguaiaretic Acid in Therapeutics: Beneficial to Toxicity Profiles and the Search for its Analogs.
Mala John GS, Takeuchi S, Venkatraman G, Rayala SK. Mala John GS, et al. Curr Cancer Drug Targets. 2020;20(2):86-103. doi: 10.2174/1568009619666191022141547. Curr Cancer Drug Targets. 2020. PMID: 31642411 Review.
Nordihydroguaiaretic acid (NDGA) is a plant lignan obtained from creosote bush, Larrea tridentata and is known to possess antioxidant, anticancer activities and is used in traditional medicine in North America and Mexico. ...
Nordihydroguaiaretic acid (NDGA) is a plant lignan obtained from creosote bush, Larrea tridentata and is known to possess anti …
Assessing Nordihydroguaiaretic Acid Therapeutic Effect for Glioblastoma Multiforme.
Manciu FS, Guerrero J, Bennet KE, Chang SY, Rahman M, Martinez Lopez LV, Chantigian S, Castellanos M, Manciu M. Manciu FS, et al. Sensors (Basel). 2022 Mar 30;22(7):2643. doi: 10.3390/s22072643. Sensors (Basel). 2022. PMID: 35408257 Free PMC article.
In this study, we demonstrate that Raman microscopy combined with computational analysis is a useful approach to discriminating accurately between brain tumor bio-specimens and to identifying structural changes in glioblastoma (GBM) bio-signatures after nordihydroguaiaretic …
In this study, we demonstrate that Raman microscopy combined with computational analysis is a useful approach to discriminating accurately b …
Nordihydroguaiaretic acid analogues: their chemical synthesis and biological activities.
Chen Q. Chen Q. Curr Top Med Chem. 2009;9(17):1636-59. doi: 10.2174/156802609789941915. Curr Top Med Chem. 2009. PMID: 19903157 Review.
Nordihydroguaiaretic acid is a natural occurring lignan mainly isolated and commercially produced from desert plant, creosote bush (Larrea divaricata Cav. ...Remarkably, terameprocol, a tetra-O-methyl derivative of nordihydroguaiaretic acid, is current …
Nordihydroguaiaretic acid is a natural occurring lignan mainly isolated and commercially produced from desert plant, creosote …
Nordihydroguaiaretic acid inhibits glyoxalase I, and causes the accumulation of methylglyoxal followed by cell-growth inhibition.
Watanabe M, Toyomura T, Ikegami R, Suwaki Y, Sada M, Wake H, Nishinaka T, Hatipoglu OF, Takahashi H, Nishibori M, Mori S. Watanabe M, et al. Mol Biol Rep. 2022 Nov;49(11):10499-10507. doi: 10.1007/s11033-022-07929-6. Epub 2022 Sep 20. Mol Biol Rep. 2022. PMID: 36127524
Glyoxalase I (GLO1) is a key enzyme for eliminating MGO in mammalian cells, therefore, compounds affecting GLO1 activity are potential therapeutic agents for MGO-induced disorders. Previously, we found nordihydroguaiaretic acid (NDGA) as a potent GLO1 inhibitor. MET …
Glyoxalase I (GLO1) is a key enzyme for eliminating MGO in mammalian cells, therefore, compounds affecting GLO1 activity are potential thera …
Nordihydroguaiaretic Acid as a Novel Substrate and Inhibitor of Catechol O-Methyltransferase Modulates 4-Hydroxyestradiol-Induced Cyto- and Genotoxicity in MCF-7 Cells.
Kim JH, Lee J, Jeong H, Bang MS, Jeong JH, Chang M. Kim JH, et al. Molecules. 2021 Apr 3;26(7):2060. doi: 10.3390/molecules26072060. Molecules. 2021. PMID: 33916785 Free PMC article.
Nordihydroguaiaretic acid (NDGA) is a major lignan metabolite found in Larrea spp., which are widely used in South America to treat various diseases. ...
Nordihydroguaiaretic acid (NDGA) is a major lignan metabolite found in Larrea spp., which are widely used in South America to …
Nordihydroguaiaretic acid prevents glycation induced structural alterations and aggregation of albumin.
Awasthi S, Preethy R, Saraswathi NT. Awasthi S, et al. Int J Biol Macromol. 2019 Feb 1;122:479-484. doi: 10.1016/j.ijbiomac.2018.10.173. Epub 2018 Oct 26. Int J Biol Macromol. 2019. PMID: 30416092
This study demonstrates the antiglycation activity of Nordihydroguaiaretic acid, a lignin from the creosote bush (Larrea tridentate), which has also been proven to assist in the treatment of cancer, neurological disorders, and cardiovascular complications. ...
This study demonstrates the antiglycation activity of Nordihydroguaiaretic acid, a lignin from the creosote bush (Larrea tride …
Nordihydroguaiaretic acid reduces secondary organ injury in septic rats after cecal ligation and puncture.
Zubrow ME, Margulies SS, Yehya N. Zubrow ME, et al. PLoS One. 2020 Aug 13;15(8):e0237613. doi: 10.1371/journal.pone.0237613. eCollection 2020. PLoS One. 2020. PMID: 32790786 Free PMC article.
BACKGROUND: Nordihydroguaiaretic acid (NDGA) is a plant extract that has been shown to act as a free radical scavenger and pluripotent inhibitor of pro-inflammatory cytokines, two major cellular processes involved in the pathophysiology of sepsis. ...
BACKGROUND: Nordihydroguaiaretic acid (NDGA) is a plant extract that has been shown to act as a free radical scavenger and plu …
A novel nordihydroguaiaretic acid analog, compound 3a, alleviates acute lung injury by exerting antiapoptotic and antiinflammatory effects.
Lin Y, Wang X, Shen M, Shi Q, Zhang J, Lu Q, Huang L, Chen C. Lin Y, et al. Eur J Pharmacol. 2022 Mar 15;919:174777. doi: 10.1016/j.ejphar.2022.174777. Epub 2022 Jan 25. Eur J Pharmacol. 2022. PMID: 35085517
Acute lung injury (ALI) is a continuum of pulmonary changes caused by various lung insults. Previously, we synthesized a series of nordihydroguaiaretic acid analogs; of these, compound 3a exhibited excellent antioxidant capacity in a murine model of middle cerebral …
Acute lung injury (ALI) is a continuum of pulmonary changes caused by various lung insults. Previously, we synthesized a series of nordih …
Effect of nordihydroguaiaretic acid on spermatogenesis and fertility in rats.
Abbas MA, Badran D, Disi A. Abbas MA, et al. Andrologia. 2018 Apr;50(3). doi: 10.1111/and.12916. Epub 2017 Nov 6. Andrologia. 2018. PMID: 29110321
Nordihydroguaiaretic acid (NDGA) is a naturally occurring lignan with potent antioxidant activity. ...
Nordihydroguaiaretic acid (NDGA) is a naturally occurring lignan with potent antioxidant activity. ...
Molecular mechanisms and clinical applications of nordihydroguaiaretic acid (NDGA) and its derivatives: an update.
Lü JM, Nurko J, Weakley SM, Jiang J, Kougias P, Lin PH, Yao Q, Chen C. Lü JM, et al. Med Sci Monit. 2010 May;16(5):RA93-100. Med Sci Monit. 2010. PMID: 20424564 Free PMC article. Review.
Creosote bush, Larrea tridentata, is known as chaparral or greasewood in the United States and as gobernadora or hediondilla in Mexico. Nordihydroguaiaretic acid (NDGA), the main metabolite of the creosote bush, has been shown to have promising applications in the t …
Creosote bush, Larrea tridentata, is known as chaparral or greasewood in the United States and as gobernadora or hediondilla in Mexico. N …
2,550 results