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Metabolomics: moving to the clinic.
Nordström A, Lewensohn R. Nordström A, et al. J Neuroimmune Pharmacol. 2010 Mar;5(1):4-17. doi: 10.1007/s11481-009-9156-4. Epub 2009 Apr 28. J Neuroimmune Pharmacol. 2010. PMID: 19399626 Review.
Over the last few years, there has been a rapidly growing number of metabolomics applications aimed at finding biomarkers which could assist diagnosis, provide therapy guidance, and evaluate response to therapy for particular diseases. Also, within the fields of drug disco …
Over the last few years, there has been a rapidly growing number of metabolomics applications aimed at finding biomarkers which could …
Multiple ionization mass spectrometry strategy used to reveal the complexity of metabolomics.
Nordström A, Want E, Northen T, Lehtiö J, Siuzdak G. Nordström A, et al. Anal Chem. 2008 Jan 15;80(2):421-9. doi: 10.1021/ac701982e. Epub 2007 Dec 18. Anal Chem. 2008. PMID: 18085752
A multiple ionization mass spectrometry strategy is presented based on the analysis of human serum extracts. Chromatographic separation was interfaced inline with the atmospheric pressure ionization techniques electrospray ionization (ESI) and atmospheric pressure chemical
A multiple ionization mass spectrometry strategy is presented based on the analysis of human serum extracts. Chromatographic separati
Discrimination of pancreatic cancer and pancreatitis by LC-MS metabolomics.
Lindahl A, Heuchel R, Forshed J, Lehtiö J, Löhr M, Nordström A. Lindahl A, et al. Among authors: nordstrom a. Metabolomics. 2017;13(5):61. doi: 10.1007/s11306-017-1199-6. Epub 2017 Apr 1. Metabolomics. 2017. PMID: 28413374 Free PMC article.
INTRODUCTION: Pancreatic ductal adenocarcinoma (PDAC) is the fifth most common cause of cancer-related death in Europe with a 5-year survival rate of <5%. Chronic pancreatitis (CP) is a risk factor for PDAC development, but in the majority of cases malignancy is …
INTRODUCTION: Pancreatic ductal adenocarcinoma (PDAC) is the fifth most common cause of cancer-related death in Europe with a 5-year …
Tuning Metabolome Coverage in Reversed Phase LC-MS Metabolomics of MeOH Extracted Samples Using the Reconstitution Solvent Composition.
Lindahl A, Sääf S, Lehtiö J, Nordström A. Lindahl A, et al. Among authors: nordstrom a. Anal Chem. 2017 Jul 18;89(14):7356-7364. doi: 10.1021/acs.analchem.7b00475. Epub 2017 Jun 28. Anal Chem. 2017. PMID: 28613827
This sample concentration step typically occurs after metabolite extraction, when dried samples are reconstituted in a solvent for injection on column. ...Reconstitution in 100% H(2)O resulted in a higher number of significant metabolites discriminating between thes …
This sample concentration step typically occurs after metabolite extraction, when dried samples are reconstituted in a solvent for in …
Current Status and Future Prospects of Clinically Exploiting Cancer-specific Metabolism-Why Is Tumor Metabolism Not More Extensively Translated into Clinical Targets and Biomarkers?
Muthu M, Nordström A. Muthu M, et al. Among authors: nordstrom a. Int J Mol Sci. 2019 Mar 19;20(6):1385. doi: 10.3390/ijms20061385. Int J Mol Sci. 2019. PMID: 30893889 Free PMC article. Review.
Tumor cells exhibit a specialized metabolism supporting their superior ability for rapid proliferation, migration, and apoptotic evasion. ...This review investigates the current efforts of using metabolomics as a tool for translation of tumor metabolism into the cli …
Tumor cells exhibit a specialized metabolism supporting their superior ability for rapid proliferation, migration, and apoptotic evas …
Overlap in serum metabolic profiles between non-related diseases: Implications for LC-MS metabolomics biomarker discovery.
Lindahl A, Forshed J, Nordström A. Lindahl A, et al. Among authors: nordstrom a. Biochem Biophys Res Commun. 2016 Sep 23;478(3):1472-7. doi: 10.1016/j.bbrc.2016.08.155. Epub 2016 Aug 28. Biochem Biophys Res Commun. 2016. PMID: 27581198
Yet, no clinically approved metabolite biomarkers have emerged with failure in validation phases often being a reason. To investigate why, we have applied untargeted metabolic profiling in a retrospective cohort of serum samples representing non-related diseases. .. …
Yet, no clinically approved metabolite biomarkers have emerged with failure in validation phases often being a reason. To investigate …
Rewired metabolism in drug-resistant leukemia cells: a metabolic switch hallmarked by reduced dependence on exogenous glutamine.
Stäubert C, Bhuiyan H, Lindahl A, Broom OJ, Zhu Y, Islam S, Linnarsson S, Lehtiö J, Nordström A. Stäubert C, et al. Among authors: nordstrom a. J Biol Chem. 2015 Mar 27;290(13):8348-59. doi: 10.1074/jbc.M114.618769. Epub 2015 Feb 19. J Biol Chem. 2015. PMID: 25697355 Free PMC article.
Here, we applied a broad spectrum of technologies including RNA sequencing, global untargeted metabolomics, and stable isotope labeling mass spectrometry to identify metabolic changes in P-glycoprotein overexpressing T-cell acute lymphoblastic leukemia (ALL) cells, which e …
Here, we applied a broad spectrum of technologies including RNA sequencing, global untargeted metabolomics, and stable isotope labeli …
Hydroxycarboxylic acid receptors are essential for breast cancer cells to control their lipid/fatty acid metabolism.
Stäubert C, Broom OJ, Nordström A. Stäubert C, et al. Among authors: nordstrom a. Oncotarget. 2015 Aug 14;6(23):19706-20. doi: 10.18632/oncotarget.3565. Oncotarget. 2015. PMID: 25839160 Free PMC article.
Furthermore, siRNA mediated knock-down of HCA3 induced considerable breast cancer cell death as did knock-down of HCA1, although to a lesser extent. Liquid Chromatography Mass Spectrometry based analyses of breast cancer cell medium revealed a role for HCA3 in contr …
Furthermore, siRNA mediated knock-down of HCA3 induced considerable breast cancer cell death as did knock-down of HCA1, although to a
Nonlinear data alignment for UPLC-MS and HPLC-MS based metabolomics: quantitative analysis of endogenous and exogenous metabolites in human serum.
Nordström A, O'Maille G, Qin C, Siuzdak G. Nordström A, et al. Anal Chem. 2006 May 15;78(10):3289-95. doi: 10.1021/ac060245f. Anal Chem. 2006. PMID: 16689529 Free PMC article.
A nonlinear alignment strategy was examined for the quantitative analysis of serum metabolites. Two small-molecule mixtures with a difference in relative concentration of 20-100% for 10 of the compounds were added to human serum. ...The length of the chromatographic
A nonlinear alignment strategy was examined for the quantitative analysis of serum metabolites. Two small-molecule mixtures with a
Surfactant-enhanced desorption/ionization on silicon mass spectrometry.
Nordström A, Apon JV, Uritboonthai W, Go EP, Siuzdak G. Nordström A, et al. Anal Chem. 2006 Jan 1;78(1):272-8. doi: 10.1021/ac051398q. Anal Chem. 2006. PMID: 16383337
Perfluorooctanesulfonic acid improved the signal-to-noise ratio of tryptic digests and gave a 3-fold increase in the number of peptides identified. ...The signal enhancement may be facilitated by the high surface activity of the perfluorinated surfactants on the fluorinate …
Perfluorooctanesulfonic acid improved the signal-to-noise ratio of tryptic digests and gave a 3-fold increase in the number of peptid …
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