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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1946 1
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1952 2
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1956 1
1960 1
1961 1
1962 2
1963 2
1964 4
1965 2
1966 2
1968 3
1969 3
1971 4
1972 4
1973 2
1974 2
1975 4
1976 10
1977 12
1978 4
1979 5
1980 9
1981 10
1982 9
1983 9
1984 5
1985 15
1986 11
1987 10
1988 10
1989 7
1990 13
1991 9
1992 9
1993 13
1994 12
1995 9
1996 3
1997 15
1998 10
1999 12
2000 18
2001 10
2002 8
2003 11
2004 14
2005 4
2006 9
2007 7
2008 8
2009 13
2010 15
2011 15
2012 15
2013 15
2014 15
2015 23
2016 15
2017 14
2018 14
2019 21
2020 16
2021 17
2022 16
2023 2
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561 results
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Norvaline and norleucine may have been more abundant protein components during early stages of cell evolution.
Alvarez-Carreño C, Becerra A, Lazcano A. Alvarez-Carreño C, et al. Orig Life Evol Biosph. 2013 Oct;43(4-5):363-75. doi: 10.1007/s11084-013-9344-3. Epub 2013 Sep 8. Orig Life Evol Biosph. 2013. PMID: 24013929 Review.
The absence of the hydrophobic norvaline and norleucine in the inventory of protein amino acids is readdressed. ...The lack of absolute substrate specificity of leucyl-tRNA synthase leads to a mischarged norvalyl-tRNA(Leu) that evades the translational proofreading activit …
The absence of the hydrophobic norvaline and norleucine in the inventory of protein amino acids is readdressed. ...The lack of absolu …
L-norvaline affects the proliferation of breast cancer cells based on the microbiome and metabolome analysis.
Zhu Q, Zai H, Zhang K, Zhang X, Luo N, Li X, Hu Y, Wu Y. Zhu Q, et al. J Appl Microbiol. 2022 Aug;133(2):1014-1026. doi: 10.1111/jam.15620. Epub 2022 May 25. J Appl Microbiol. 2022. PMID: 35543360

Compared with the L-norvaline or doxorubicin hydrochloride (DOX) group, the proliferation abilities of 4 T1 cells were the lowest in the L-norvaline combined with DOX (p < 0.05). ...L-norvaline combined with DOX could clearly inhibit the proliferation acti

…
Compared with the L-norvaline or doxorubicin hydrochloride (DOX) group, the proliferation abilities of 4 T1 cells were the lowest in …
Antihyperglycemic activity of L-norvaline and L-arginine in high-fat diet and streptozotocin-treated male rats.
Javrushyan H, Nadiryan E, Grigoryan A, Avtandilyan N, Maloyan A. Javrushyan H, et al. Exp Mol Pathol. 2022 Jun;126:104763. doi: 10.1016/j.yexmp.2022.104763. Epub 2022 Apr 7. Exp Mol Pathol. 2022. PMID: 35398371

RESULTS: Treatment of HFD/STZ mice with L-norvaline and L-arginine reduced fasting blood glucose levels by 27.1% vs. untreated HFD/STZ rats (p < 0.001). Blood levels of total cholesterol, low-density lipoprotein (LDL), and malondialdehyde (MDA), a marker for oxidative s

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RESULTS: Treatment of HFD/STZ mice with L-norvaline and L-arginine reduced fasting blood glucose levels by 27.1% vs. untreated HFD/ST …
L-Norvaline, a new therapeutic agent against Alzheimer's disease.
Polis B, Srikanth KD, Gurevich V, Gil-Henn H, Samson AO. Polis B, et al. Neural Regen Res. 2019 Sep;14(9):1562-1572. doi: 10.4103/1673-5374.255980. Neural Regen Res. 2019. PMID: 31089055 Free PMC article.
Through these modes of action, L-norvaline has the potential to improve the symptoms of AD and even interferes with its pathogenesis. As such, L-norvaline is a promising neuroprotective molecule that might be tailored for the treatment of a range of neurodegenerativ …
Through these modes of action, L-norvaline has the potential to improve the symptoms of AD and even interferes with its pathogenesis. …
Efficacy of epetraborole against Mycobacterium abscessus is increased with norvaline.
Sullivan JR, Lupien A, Kalthoff E, Hamela C, Taylor L, Munro KA, Schmeing TM, Kremer L, Behr MA. Sullivan JR, et al. PLoS Pathog. 2021 Oct 12;17(10):e1009965. doi: 10.1371/journal.ppat.1009965. eCollection 2021 Oct. PLoS Pathog. 2021. PMID: 34637487 Free PMC article.
Since EPT-resistant M. abscessus mutants lost LeuRS editing activity, these mutants became susceptible to misaminoacylation with leucine mimics like the non-proteinogenic amino acid norvaline. Proteomic analysis revealed that when M. abscessus LeuRS mutants were fed nor …
Since EPT-resistant M. abscessus mutants lost LeuRS editing activity, these mutants became susceptible to misaminoacylation with leucine mim …
Leucyl-tRNA Synthetase Inhibitor, D-Norvaline, in Combination with Oxacillin, Is Effective against Methicillin-Resistant Staphylococcus aureus.
Lee HJ, Kim B, Kim S, Cho DH, Jung H, Kim W, Kim YG, Kim JS, Joo HS, Lee SH, Yang YH. Lee HJ, et al. Antibiotics (Basel). 2022 May 18;11(5):683. doi: 10.3390/antibiotics11050683. Antibiotics (Basel). 2022. PMID: 35625327 Free PMC article.
Additionally, we observed genetic differences to explore the response to D-norvaline. Furthermore, deletion mutants and clinically isolated MRSA strains were treated with D-norvaline. The study revealed that D-norvaline, with low concentrations of oxacillin, …
Additionally, we observed genetic differences to explore the response to D-norvaline. Furthermore, deletion mutants and clinically is …
Reports of L-Norvaline Toxicity in Humans May Be Greatly Overstated.
Polis B, Gilinsky MA, Samson AO. Polis B, et al. Brain Sci. 2019 Dec 17;9(12):382. doi: 10.3390/brainsci9120382. Brain Sci. 2019. PMID: 31861122 Free PMC article.
Rodgers) was entitled: "Cytotoxicity and Mitochondrial Dysfunction Caused by the Dietary Supplement L-Norvaline". The title may be greatly overstated, and here we provide several arguments showing that norvaline is not as toxic as reported....
Rodgers) was entitled: "Cytotoxicity and Mitochondrial Dysfunction Caused by the Dietary Supplement L-Norvaline". The title may be gr …
Norvaline Restores the BBB Integrity in a Mouse Model of Alzheimer's Disease.
Polis B, Gurevich V, Assa M, Samson AO. Polis B, et al. Int J Mol Sci. 2019 Sep 18;20(18):4616. doi: 10.3390/ijms20184616. Int J Mol Sci. 2019. PMID: 31540372 Free PMC article.
We utilized a homozygous triple-transgenic mouse model of AD (3Tg-AD) to assess the effects of L-norvaline on BBB integrity. We scrutinized the perivascular astrocytes and macrophages by measuring the immunopositive profiles in relation to the presence of beta-amyloid and …
We utilized a homozygous triple-transgenic mouse model of AD (3Tg-AD) to assess the effects of L-norvaline on BBB integrity. We scrut …
Norvaline Reduces Blood Pressure and Induces Diuresis in Rats with Inherited Stress-Induced Arterial Hypertension.
Gilinsky MA, Polityko YK, Markel AL, Latysheva TV, Samson AO, Polis B, Naumenko SE. Gilinsky MA, et al. Biomed Res Int. 2020 Feb 12;2020:4935386. doi: 10.1155/2020/4935386. eCollection 2020. Biomed Res Int. 2020. PMID: 32149110 Free PMC article.
Experimental animals were intraperitoneally administered for seven days with nonproteinogenic amino acid L-norvaline (30 mg/kg/day), which is a potent arginase inhibitor, or with the vehicle. ...Moreover, we suggest that changes in blood and urine are causally related to t …
Experimental animals were intraperitoneally administered for seven days with nonproteinogenic amino acid L-norvaline (30 mg/kg/day), …
Norvaline is accumulated after a down-shift of oxygen in Escherichia coli W3110.
Soini J, Falschlehner C, Liedert C, Bernhardt J, Vuoristo J, Neubauer P. Soini J, et al. Microb Cell Fact. 2008 Oct 21;7:30. doi: 10.1186/1475-2859-7-30. Microb Cell Fact. 2008. PMID: 18940002 Free PMC article.
Norvaline accumulates immediately after a shift to oxygen limitation at high glucose concentration. On the contrary free norvaline is not accumulated in E. coli W3110 in aerobic cultures. ...
Norvaline accumulates immediately after a shift to oxygen limitation at high glucose concentration. On the contrary free norvaline …
561 results