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mGlu1 Receptors Monopolize the Synaptic Control of Cerebellar Purkinje Cells by Epigenetically Down-Regulating mGlu5 Receptors.
Notartomaso S, Nakao H, Mascio G, Scarselli P, Cannella M, Zappulla C, Madonna M, Motolese M, Gradini R, Liberatore F, Zonta M, Carmignoto G, Battaglia G, Bruno V, Watanabe M, Aiba A, Nicoletti F. Notartomaso S, et al. Sci Rep. 2018 Sep 6;8(1):13361. doi: 10.1038/s41598-018-31369-7. Sci Rep. 2018. PMID: 30190524 Free PMC article.
Switch in the expression of mGlu1 and mGlu5 metabotropic glutamate receptors in the cerebellum of mice developing experimental autoimmune encephalomyelitis and in autoptic cerebellar samples from patients with multiple sclerosis.
Fazio F, Notartomaso S, Aronica E, Storto M, Battaglia G, Vieira E, Gatti S, Bruno V, Biagioni F, Gradini R, Nicoletti F, Di Marco R. Fazio F, et al. Among authors: notartomaso s. Neuropharmacology. 2008 Sep;55(4):491-9. doi: 10.1016/j.neuropharm.2008.06.066. Epub 2008 Jul 8. Neuropharmacology. 2008. PMID: 18619983
Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors.
Fazio F, Lionetto L, Molinaro G, Bertrand HO, Acher F, Ngomba RT, Notartomaso S, Curini M, Rosati O, Scarselli P, Di Marco R, Battaglia G, Bruno V, Simmaco M, Pin JP, Nicoletti F, Goudet C. Fazio F, et al. Among authors: notartomaso s. Mol Pharmacol. 2012 May;81(5):643-56. doi: 10.1124/mol.111.074765. Epub 2012 Feb 6. Mol Pharmacol. 2012. PMID: 22311707
Pharmacological enhancement of mGlu1 metabotropic glutamate receptors causes a prolonged symptomatic benefit in a mouse model of spinocerebellar ataxia type 1.
Notartomaso S, Zappulla C, Biagioni F, Cannella M, Bucci D, Mascio G, Scarselli P, Fazio F, Weisz F, Lionetto L, Simmaco M, Gradini R, Battaglia G, Signore M, Puliti A, Nicoletti F. Notartomaso S, et al. Mol Brain. 2013 Nov 19;6:48. doi: 10.1186/1756-6606-6-48. Mol Brain. 2013. PMID: 24252411 Free PMC article.
Cinnabarinic acid, an endogenous agonist of type-4 metabotropic glutamate receptor, suppresses experimental autoimmune encephalomyelitis in mice.
Fazio F, Zappulla C, Notartomaso S, Busceti C, Bessede A, Scarselli P, Vacca C, Gargaro M, Volpi C, Allegrucci M, Lionetto L, Simmaco M, Belladonna ML, Nicoletti F, Fallarino F. Fazio F, et al. Among authors: notartomaso s. Neuropharmacology. 2014 Jun;81:237-43. doi: 10.1016/j.neuropharm.2014.02.011. Epub 2014 Feb 21. Neuropharmacology. 2014. PMID: 24565643
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