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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1992 1
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2000 16
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2003 28
2004 35
2005 20
2006 16
2007 20
2008 18
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2010 25
2011 25
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2013 32
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553 results

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Page 1
A regulatory T cell Notch4-GDF15 axis licenses tissue inflammation in asthma.
Harb H, Stephen-Victor E, Crestani E, Benamar M, Massoud A, Cui Y, Charbonnier LM, Arbag S, Baris S, Cunnigham A, Leyva-Castillo JM, Geha RS, Mousavi AJ, Guennewig B, Schmitz-Abe K, Sioutas C, Phipatanakul W, Chatila TA. Harb H, et al. Nat Immunol. 2020 Nov;21(11):1359-1370. doi: 10.1038/s41590-020-0777-3. Epub 2020 Sep 14. Nat Immunol. 2020. PMID: 32929274 Free PMC article.
We found that interleukin-6- and STAT3 transcription factor-dependent upregulation of Notch4 receptor on lung tissue regulatory T (T(reg)) cells is necessary for allergens and particulate matter pollutants to promote airway inflammation. ...Our studies thus identify …
We found that interleukin-6- and STAT3 transcription factor-dependent upregulation of Notch4 receptor on lung tissue regulator …
Notch4 signaling limits regulatory T-cell-mediated tissue repair and promotes severe lung inflammation in viral infections.
Harb H, Benamar M, Lai PS, Contini P, Griffith JW, Crestani E, Schmitz-Abe K, Chen Q, Fong J, Marri L, Filaci G, Del Zotto G, Pishesha N, Kolifrath S, Broggi A, Ghosh S, Gelmez MY, Oktelik FB, Cetin EA, Kiykim A, Kose M, Wang Z, Cui Y, Yu XG, Li JZ, Berra L, Stephen-Victor E, Charbonnier LM, Zanoni I, Ploegh H, Deniz G, De Palma R, Chatila TA. Harb H, et al. Immunity. 2021 Jun 8;54(6):1186-1199.e7. doi: 10.1016/j.immuni.2021.04.002. Epub 2021 Apr 28. Immunity. 2021. PMID: 33915108 Free PMC article.
Deletion of Notch4 in Treg cells or therapy with anti-Notch4 antibodies in conventional and humanized mice normalized the dysregulated innate immunity and rescued disease morbidity and mortality induced by a synthetic analog of viral RNA or by influenza H1N1 virus. …
Deletion of Notch4 in Treg cells or therapy with anti-Notch4 antibodies in conventional and humanized mice normalized the dysr …
General Capillary Endothelial Cells Undergo Reprogramming Into Arterial Endothelial Cells in Pulmonary Hypertension Through HIF-2alpha/Notch4 Pathway.
Liu B, Yi D, Xia X, Ramirez K, Zhao H, Cao Y, Tripathi A, Dong R, Gao A, Ding H, Qiu S, Kalinichenko VV, Zhao YY, Fallon MB, Dai Z. Liu B, et al. Circulation. 2024 Jul 30;150(5):414-417. doi: 10.1161/CIRCULATIONAHA.123.067981. Epub 2024 Jul 29. Circulation. 2024. PMID: 39074180 Free PMC article. No abstract available.
Inhibition of NOTCH4 sensitizes FLT3/ITD acute myeloid leukemia cells to FLT3 tyrosine kinase inhibition.
Zhu R, Shirley CM, Chu SH, Li L, Nguyen BH, Seo J, Wu M, Seale T, Duffield AS, Staudt LM, Levis M, Hu Y, Small D. Zhu R, et al. Leukemia. 2024 Jul;38(7):1581-1591. doi: 10.1038/s41375-024-02292-w. Epub 2024 May 29. Leukemia. 2024. PMID: 38811818
In a loss-of-function RNAi screen, we identified NOTCH4 as one such potential target whose inhibition proved cytotoxic to AML cells, and also sensitized them to FLT3 inhibition. Further investigation found increased NOTCH4 expression in FLT3/ITD AML cell lines and p …
In a loss-of-function RNAi screen, we identified NOTCH4 as one such potential target whose inhibition proved cytotoxic to AML cells, …
Tumor angiogenesis.
Kerbel RS. Kerbel RS. N Engl J Med. 2008 May 8;358(19):2039-49. doi: 10.1056/NEJMra0706596. N Engl J Med. 2008. PMID: 18463380 Free PMC article. Review. No abstract available.
A common IL-4 receptor variant promotes asthma severity via a T(reg) cell GRB2-IL-6-Notch4 circuit.
Benamar M, Harb H, Chen Q, Wang M, Chan TMF, Fong J, Phipatanakul W, Cunningham A, Ertem D, Petty CR, Mousavi AJ, Sioutas C, Crestani E, Chatila TA. Benamar M, et al. Allergy. 2022 Nov;77(11):3377-3387. doi: 10.1111/all.15444. Epub 2022 Jul 25. Allergy. 2022. PMID: 35841382 Free PMC article.
Mice harboring the Il4ra(R576) allele exhibited increased Notch4-dependent allergic airway inflammation that was inhibited upon T(reg) cell-specific Notch4 deletion or treatment with an anti-Notch4 antibody. ...This upregulation was dependent on growth factor …
Mice harboring the Il4ra(R576) allele exhibited increased Notch4-dependent allergic airway inflammation that was inhibited upon T(reg …
JAG1-NOTCH4 mechanosensing drives atherosclerosis.
Souilhol C, Tardajos Ayllon B, Li X, Diagbouga MR, Zhou Z, Canham L, Roddie H, Pirri D, Chambers EV, Dunning MJ, Ariaans M, Li J, Fang Y, Jørgensen HF, Simons M, Krams R, Waltenberger J, Fragiadaki M, Ridger V, De Val S, Francis SE, Chico TJ, Serbanovic-Canic J, Evans PC. Souilhol C, et al. Sci Adv. 2022 Sep 2;8(35):eabo7958. doi: 10.1126/sciadv.abo7958. Epub 2022 Aug 31. Sci Adv. 2022. PMID: 36044575 Free PMC article.
Here, we show using porcine and murine arteries and cultured human coronary artery EC that disturbed flow activates the JAG1-NOTCH4 signaling pathway. Light-sheet imaging revealed enrichment of JAG1 and NOTCH4 in EC of atherosclerotic plaques, and EC-specific geneti …
Here, we show using porcine and murine arteries and cultured human coronary artery EC that disturbed flow activates the JAG1-NOTCH4 s …
Androgen receptor suppresses vasculogenic mimicry in hepatocellular carcinoma via circRNA7/miRNA7-5p/VE-cadherin/Notch4 signalling.
Bao S, Jin S, Wang C, Tu P, Hu K, Lu J. Bao S, et al. J Cell Mol Med. 2020 Dec;24(23):14110-14120. doi: 10.1111/jcmm.16022. Epub 2020 Oct 28. J Cell Mol Med. 2020. PMID: 33118329 Free PMC article.
Androgen receptor (AR) can suppress hepatocellular carcinoma (HCC) invasion and metastasis at an advanced stage. ...The results suggested that AR could down-regulate circular RNA (circRNA) 7, up-regulate micro RNA (miRNA) 7-5p, and suppress the formation of VM in HCC Small …
Androgen receptor (AR) can suppress hepatocellular carcinoma (HCC) invasion and metastasis at an advanced stage. ...The results sugge …
Notch4 regulatory T cells and SARS-CoV-2 viremia shape COVID19 survival outcome.
Benamar M, Lai PS, Huang CY, Chen Q, Oktelik FB, Contini P, Wang M, Okin D, Crestani E, Fong J, Fion TMC, Gokbak MN, Harb H, Phipatanakul W, Marri L, Vassallo C, Guastalla A, Kim M, Sui HY, Berra L, Goldberg MB, Angelini C, De Palma R, Chatila TA. Benamar M, et al. Allergy. 2025 Feb;80(2):557-569. doi: 10.1111/all.16333. Epub 2024 Oct 3. Allergy. 2025. PMID: 39361431 Free PMC article.
A mouse model of lethal H1N1 influenza infection was used to analyze the therapeutic potential of Notch4 and pyroptosis inhibition in disease outcome. RESULTS: Stratifying patients based on %Notch4(+) Treg cells and/or the presence of plasma viremia identified four …
A mouse model of lethal H1N1 influenza infection was used to analyze the therapeutic potential of Notch4 and pyroptosis inhibition in …
Stroke genetics update.
Alberts MJ. Alberts MJ. Stroke. 2003 Feb;34(2):342-4. doi: 10.1161/01.str.0000054263.67434.be. Stroke. 2003. PMID: 12574530 Review. No abstract available.
553 results