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Year Number of Results
1996 3
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2005 3
2006 4
2007 2
2008 3
2009 5
2010 14
2011 16
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578 results

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Page 1
Alzheimer's disease.
Scheltens P, De Strooper B, Kivipelto M, Holstege H, Chételat G, Teunissen CE, Cummings J, van der Flier WM. Scheltens P, et al. Lancet. 2021 Apr 24;397(10284):1577-1590. doi: 10.1016/S0140-6736(20)32205-4. Epub 2021 Mar 2. Lancet. 2021. PMID: 33667416 Free PMC article. Review.
The risk of Alzheimer's disease is 60-80% dependent on heritable factors, with more than 40 Alzheimer's disease-associated genetic risk loci already identified, of which the APOE alleles have the strongest association with the d …
The risk of Alzheimer's disease is 60-80% dependent on heritable factors, with more than 40 Alzheimer's …
Systematic druggable genome-wide Mendelian randomisation identifies therapeutic targets for Alzheimer's disease.
Su WM, Gu XJ, Dou M, Duan QQ, Jiang Z, Yin KF, Cai WC, Cao B, Wang Y, Chen YP. Su WM, et al. J Neurol Neurosurg Psychiatry. 2023 Nov;94(11):954-961. doi: 10.1136/jnnp-2023-331142. Epub 2023 Jun 22. J Neurol Neurosurg Psychiatry. 2023. PMID: 37349091 Free PMC article.
BACKGROUND: Alzheimer's disease (AD) is the leading cause of dementia. Currently, there are no effective disease-modifying treatments for AD. Mendelian randomisation (MR) has been widely used to repurpose licensed drugs and discover novel therap …
BACKGROUND: Alzheimer's disease (AD) is the leading cause of dementia. Currently, there are no effective disease …
Pinpointing novel risk loci for Lewy body dementia and the shared genetic etiology with Alzheimer's disease and Parkinson's disease: a large-scale multi-trait association analysis.
Guo P, Gong W, Li Y, Liu L, Yan R, Wang Y, Zhang Y, Yuan Z. Guo P, et al. BMC Med. 2022 Jun 22;20(1):214. doi: 10.1186/s12916-022-02404-2. BMC Med. 2022. PMID: 35729600 Free PMC article.
In addition, the genetic determinants underlying LBD and the shared genetic etiology with Alzheimer's disease (AD) and Parkinson's disease (PD) remain poorly understood. METHODS: Using the largest GWAS summary statistics of LBD to date (2591 cases and …
In addition, the genetic determinants underlying LBD and the shared genetic etiology with Alzheimer's disease (AD) and …
The complex genetic architecture of Alzheimer's disease: novel insights and future directions.
Andrews SJ, Renton AE, Fulton-Howard B, Podlesny-Drabiniok A, Marcora E, Goate AM. Andrews SJ, et al. EBioMedicine. 2023 Apr;90:104511. doi: 10.1016/j.ebiom.2023.104511. Epub 2023 Mar 10. EBioMedicine. 2023. PMID: 36907103 Free PMC article. Review.
BACKGROUND: Alzheimer's disease (AD) is a complex multifactorial neurodegenerative disorder and the most common form of dementia. ...Until recently these efforts had identified 39 disease susceptibility loci in European ancestry populations. REC …
BACKGROUND: Alzheimer's disease (AD) is a complex multifactorial neurodegenerative disorder and the most common form of …
Novel loci for Alzheimer's disease identified by a genome-wide association study in Ashkenazi Jews.
Li D, Farrell JJ, Mez J, Martin ER, Bush WS, Ruiz A, Boada M, de Rojas I, Mayeux R, Haines JL, Vance MAP, Wang LS, Schellenberg GD, Lunetta KL, Farrer LA. Li D, et al. Alzheimers Dement. 2023 Dec;19(12):5550-5562. doi: 10.1002/alz.13117. Epub 2023 Jun 1. Alzheimers Dement. 2023. PMID: 37260021 Free PMC article.
INTRODUCTION: Most Alzheimer's disease (AD) loci have been discovered in individuals with European ancestry (EA). ...
INTRODUCTION: Most Alzheimer's disease (AD) loci have been discovered in individuals with European ancestry (EA) …
Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk.
Jansen IE, Savage JE, Watanabe K, Bryois J, Williams DM, Steinberg S, Sealock J, Karlsson IK, Hägg S, Athanasiu L, Voyle N, Proitsi P, Witoelar A, Stringer S, Aarsland D, Almdahl IS, Andersen F, Bergh S, Bettella F, Bjornsson S, Brækhus A, Bråthen G, de Leeuw C, Desikan RS, Djurovic S, Dumitrescu L, Fladby T, Hohman TJ, Jonsson PV, Kiddle SJ, Rongve A, Saltvedt I, Sando SB, Selbæk G, Shoai M, Skene NG, Snaedal J, Stordal E, Ulstein ID, Wang Y, White LR, Hardy J, Hjerling-Leffler J, Sullivan PF, van der Flier WM, Dobson R, Davis LK, Stefansson H, Stefansson K, Pedersen NL, Ripke S, Andreassen OA, Posthuma D. Jansen IE, et al. Nat Genet. 2019 Mar;51(3):404-413. doi: 10.1038/s41588-018-0311-9. Epub 2019 Jan 7. Nat Genet. 2019. PMID: 30617256 Free PMC article.
Alzheimer's disease (AD) is highly heritable and recent studies have identified over 20 disease-associated genomic loci. ...These results are a step forward in identifying the genetic factors that contribute to AD risk and add novel insig …
Alzheimer's disease (AD) is highly heritable and recent studies have identified over 20 disease-associated genom …
Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel: A Meta-analysis.
Kunkle BW, Schmidt M, Klein HU, Naj AC, Hamilton-Nelson KL, Larson EB, Evans DA, De Jager PL, Crane PK, Buxbaum JD, Ertekin-Taner N, Barnes LL, Fallin MD, Manly JJ, Go RCP, Obisesan TO, Kamboh MI, Bennett DA, Hall KS, Goate AM, Foroud TM, Martin ER, Wang LS, Byrd GS, Farrer LA, Haines JL, Schellenberg GD, Mayeux R, Pericak-Vance MA, Reitz C; Writing Group for the Alzheimer’s Disease Genetics Consortium (ADGC); Graff-Radford NR, Martinez I, Ayodele T, Logue MW, Cantwell LB, Jean-Francois M, Kuzma AB, Adams LD, Vance JM, Cuccaro ML, Chung J, Mez J, Lunetta KL, Jun GR, Lopez OL, Hendrie HC, Reiman EM, Kowall NW, Leverenz JB, Small SA, Levey AI, Golde TE, Saykin AJ, Starks TD, Albert MS, Hyman BT, Petersen RC, Sano M, Wisniewski T, Vassar R, Kaye JA, Henderson VW, DeCarli C, LaFerla FM, Brewer JB, Miller BL, Swerdlow RH, Van Eldik LJ, Paulson HL, Trojanowski JQ, Chui HC, Rosenberg RN, Craft S, Grabowski TJ, Asthana S, Morris JC, Strittmatter SM, Kukull WA. Kunkle BW, et al. JAMA Neurol. 2021 Jan 1;78(1):102-113. doi: 10.1001/jamaneurol.2020.3536. JAMA Neurol. 2021. PMID: 33074286 Free PMC article.
MAIN OUTCOMES AND MEASURES: Diagnosis of Alzheimer disease. RESULTS: A total of 2784 individuals with Alzheimer disease (1944 female [69.8%]) and 5222 controls (3743 female [71.7%]) were analyzed (mean [SD] age at last evaluation, 74.2 [13.6] years). . …
MAIN OUTCOMES AND MEASURES: Diagnosis of Alzheimer disease. RESULTS: A total of 2784 individuals with Alzheimer dise …
Mouse Models of Alzheimer's Disease.
Esquerda-Canals G, Montoliu-Gaya L, Güell-Bosch J, Villegas S. Esquerda-Canals G, et al. J Alzheimers Dis. 2017;57(4):1171-1183. doi: 10.3233/JAD-170045. J Alzheimers Dis. 2017. PMID: 28304309 Review.
Alzheimer's disease (AD) is a neurodegenerative disorder that nowadays affects more than 40 million people worldwide and it is predicted to exponentially increase in the coming decades. ...Further novel information about the disease will allow f …
Alzheimer's disease (AD) is a neurodegenerative disorder that nowadays affects more than 40 million people worldwide an …
Proteomic landscape of Alzheimer's Disease: novel insights into pathogenesis and biomarker discovery.
Bai B, Vanderwall D, Li Y, Wang X, Poudel S, Wang H, Dey KK, Chen PC, Yang K, Peng J. Bai B, et al. Mol Neurodegener. 2021 Aug 12;16(1):55. doi: 10.1186/s13024-021-00474-z. Mol Neurodegener. 2021. PMID: 34384464 Free PMC article. Review.
Mass spectrometry-based proteomics empowers deep profiling of proteome and protein posttranslational modifications (PTMs) in Alzheimer's disease (AD). Here we review the advances and limitations in historic and recent AD proteomic research. ...In particular, …
Mass spectrometry-based proteomics empowers deep profiling of proteome and protein posttranslational modifications (PTMs) in Alzheimer …
Interpretation of risk loci from genome-wide association studies of Alzheimer's disease.
Andrews SJ, Fulton-Howard B, Goate A. Andrews SJ, et al. Lancet Neurol. 2020 Apr;19(4):326-335. doi: 10.1016/S1474-4422(19)30435-1. Epub 2020 Jan 24. Lancet Neurol. 2020. PMID: 31986256 Free PMC article. Review.
This meta-analysis discovered 19 susceptibility loci for Alzheimer's disease in populations of European ancestry. RECENT DEVELOPMENTS: Three new Alzheimer's disease GWAS published in 2018 and 2019, which used larger sample sizes an …
This meta-analysis discovered 19 susceptibility loci for Alzheimer's disease in populations of European ancestry …
578 results