Novinec M - Search Results

1

Zinc pyrithione is a potent inhibitor of PL^Pro and cathepsin L enzymes with ex vivo inhibition of SARS-CoV-2 entry and replication.

Kladnik J, Dolinar A, Kljun J, Perea D, Grau-Expósito J, Genescà M, Novinec M, Buzon MJ, Turel I. Kladnik J, et al. Among authors: novinec m. J Enzyme Inhib Med Chem. 2022 Dec;37(1):2158-2168. doi: 10.1080/14756366.2022.2108417. J Enzyme Inhib Med Chem. 2022. PMID: 35943189 Free PMC article.

2

Regioselective Synthesis of 5- and 3-Hydroxy-N-Aryl-1H-Pyrazole-4-Carboxylates and Their Evaluation as Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase.

Vah L, Medved T, Grošelj U, Klemenčič M, Podlipnik Č, Štefane B, Wagger J, Novinec M, Svete J. Vah L, et al. Among authors: novinec m. Molecules. 2022 Jul 25;27(15):4764. doi: 10.3390/molecules27154764. Molecules. 2022. PMID: 35897941 Free PMC article.

3

Evolutionary Analysis of Dipeptidyl Peptidase I.

Varda N, Novinec M. Varda N, et al. Among authors: novinec m. Int J Mol Sci. 2022 Feb 6;23(3):1852. doi: 10.3390/ijms23031852. Int J Mol Sci. 2022. PMID: 35163774 Free PMC article.

4

Structural polymorphism of coiled-coils from the stalk domain of SARS-CoV-2 spike protein.

Živič Z, Strmšek Ž, Novinec M, Lah J, Hadži S. Živič Z, et al. Among authors: novinec m. FASEB J. 2022 Mar;36(3):e22199. doi: 10.1096/fj.202101670R. FASEB J. 2022. PMID: 35157347 Free PMC article.

5

Synthesis and kinetic characterization of hyperbolic inhibitors of human cathepsins K and S based on a succinimide scaffold.

Goričan T, Ciber L, Petek N, Svete J, Novinec M. Goričan T, et al. Among authors: novinec m. Bioorg Chem. 2021 Oct;115:105213. doi: 10.1016/j.bioorg.2021.105213. Epub 2021 Jul 28. Bioorg Chem. 2021. PMID: 34364050

6

Inhibition of Human Cathepsins B and L by Caffeic Acid and Its Derivatives.

Ulčakar L, Novinec M. Ulčakar L, et al. Among authors: novinec m. Biomolecules. 2020 Dec 29;11(1):31. doi: 10.3390/biom11010031. Biomolecules. 2020. PMID: 33383850 Free PMC article.

7

Interplay between tetrameric structure, enzymatic activity and allosteric regulation of human dipeptidyl-peptidase I.

Rebernik M, Snoj T, Klemenčič M, Novinec M. Rebernik M, et al. Among authors: novinec m. Arch Biochem Biophys. 2019 Oct 30;675:108121. doi: 10.1016/j.abb.2019.108121. Epub 2019 Sep 28. Arch Biochem Biophys. 2019. PMID: 31574257

8

Tetrahydro-1H,5H-pyrazolo[1,2-a]pyrazole-1-carboxylates as inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase.

Strašek N, Lavrenčič L, Oštrek A, Slapšak D, Grošelj U, Klemenčič M, Brodnik Žugelj H, Wagger J, Novinec M, Svete J. Strašek N, et al. Among authors: novinec m. Bioorg Chem. 2019 Aug;89:102982. doi: 10.1016/j.bioorg.2019.102982. Epub 2019 May 15. Bioorg Chem. 2019. PMID: 31132601

9

The catalytic domain of cathepsin C (dipeptidyl-peptidase I) alone is a fully functional endoprotease.

Rebernik M, Lenarčič B, Novinec M. Rebernik M, et al. Among authors: novinec m. Protein Expr Purif. 2019 May;157:21-27. doi: 10.1016/j.pep.2019.01.009. Epub 2019 Jan 29. Protein Expr Purif. 2019. PMID: 30703555

10

Synthesis and biological evaluation of 7-(aminoalkyl)pyrazolo[1,5-a]pyrimidine derivatives as cathepsin K inhibitors.

Petek N, Štefane B, Novinec M, Svete J. Petek N, et al. Among authors: novinec m. Bioorg Chem. 2019 Mar;84:226-238. doi: 10.1016/j.bioorg.2018.11.029. Epub 2018 Nov 19. Bioorg Chem. 2019. PMID: 30502634

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