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Year Number of Results
1997 1
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2002 13
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2005 30
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2007 32
2008 64
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2010 74
2011 75
2012 100
2013 122
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2,358 results

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Page 1
Oxidative Stress.
Sies H, Berndt C, Jones DP. Sies H, et al. Annu Rev Biochem. 2017 Jun 20;86:715-748. doi: 10.1146/annurev-biochem-061516-045037. Epub 2017 Apr 24. Annu Rev Biochem. 2017. PMID: 28441057 Review.
Redox balance is maintained by prevention, interception, and repair, and concomitantly the regulatory potential of molecular thiol-driven master switches such as Nrf2/Keap1 or NF-kappaB/IkappaB is used for system-wide oxidative stress response. Nonradical species su …
Redox balance is maintained by prevention, interception, and repair, and concomitantly the regulatory potential of molecular thiol-driven ma …
Glutathione synthesis.
Lu SC. Lu SC. Biochim Biophys Acta. 2013 May;1830(5):3143-53. doi: 10.1016/j.bbagen.2012.09.008. Epub 2012 Sep 17. Biochim Biophys Acta. 2013. PMID: 22995213 Free PMC article. Review.
Key transcription factors that regulate the expression of these genes include NF-E2 related factor 2 (Nrf2) via the antioxidant response element (ARE), AP-1, and nuclear factor kappa B (NFkappaB). ...This article is part of a Special Issue entitled Cellular f …
Key transcription factors that regulate the expression of these genes include NF-E2 related factor 2 (Nrf2) via the antioxidant …
Remote ischemic conditioning attenuates oxidative stress and inflammation via the Nrf2/HO-1 pathway in MCAO mice.
Sun YY, Zhu HJ, Zhao RY, Zhou SY, Wang MQ, Yang Y, Guo ZN. Sun YY, et al. Redox Biol. 2023 Oct;66:102852. doi: 10.1016/j.redox.2023.102852. Epub 2023 Aug 16. Redox Biol. 2023. PMID: 37598463 Free PMC article.
This study aimed to investigate whether RIC could reduce oxidative stress and inflammatory responses in middle cerebral artery occlusion (MCAO)-reperfusion mice via the nuclear factor-E2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) pathway. ...Oxidative stress le …
This study aimed to investigate whether RIC could reduce oxidative stress and inflammatory responses in middle cerebral artery occlus …
The thioredoxin antioxidant system.
Lu J, Holmgren A. Lu J, et al. Free Radic Biol Med. 2014 Jan;66:75-87. doi: 10.1016/j.freeradbiomed.2013.07.036. Epub 2013 Jul 27. Free Radic Biol Med. 2014. PMID: 23899494 Review.
Moreover, Trx systems play critical roles in the immune response, virus infection, and cell death via interaction with thioredoxin-interacting protein. In mammalian cells, the cytosolic and mitochondrial Trx systems, in which TrxRs are high molecular weight selenoenzymes, …
Moreover, Trx systems play critical roles in the immune response, virus infection, and cell death via interaction with thioredoxin-in …
Redox regulation: mechanisms, biology and therapeutic targets in diseases.
Li B, Ming H, Qin S, Nice EC, Dong J, Du Z, Huang C. Li B, et al. Signal Transduct Target Ther. 2025 Mar 7;10(1):72. doi: 10.1038/s41392-024-02095-6. Signal Transduct Target Ther. 2025. PMID: 40050273 Free PMC article. Review.
Under physiological conditions, oxidative free radicals generated by the mitochondrial oxidative respiratory chain, endoplasmic reticulum, and NADPH oxidases can be effectively neutralized by NRF2-mediated antioxidant responses. These responses elevate …
Under physiological conditions, oxidative free radicals generated by the mitochondrial oxidative respiratory chain, endoplasmic reticulum, a …
The Nrf2 antioxidant defense system in intervertebral disc degeneration: Molecular insights.
Xiang Q, Zhao Y, Lin J, Jiang S, Li W. Xiang Q, et al. Exp Mol Med. 2022 Aug;54(8):1067-1075. doi: 10.1038/s12276-022-00829-6. Epub 2022 Aug 17. Exp Mol Med. 2022. PMID: 35978054 Free PMC article. Review.
Accumulating evidence has revealed that Nrf2 can facilitate the transcription of downstream antioxidant genes in disc cells by binding to antioxidant response elements (AREs) in promoter regions, including heme oxygenase-1 (HO-1), glutathione (G …
Accumulating evidence has revealed that Nrf2 can facilitate the transcription of downstream antioxidant genes in disc cells by …
Fasting Drives Nrf2-Related Antioxidant Response in Skeletal Muscle.
Lettieri-Barbato D, Minopoli G, Caggiano R, Izzo R, Santillo M, Aquilano K, Faraonio R. Lettieri-Barbato D, et al. Int J Mol Sci. 2020 Oct 21;21(20):7780. doi: 10.3390/ijms21207780. Int J Mol Sci. 2020. PMID: 33096672 Free PMC article.
The nuclear factor erythroid 2-related factor 2 (Nrf2) controls adaptive responses and remains the major regulator of quenching mechanisms underlying different types of stress. ...In particular, by using in vivo and in vitro models of fasting, we found that typical …
The nuclear factor erythroid 2-related factor 2 (Nrf2) controls adaptive responses and remains the major regulator of quenchin …
The Keap1-Nrf2-antioxidant response element pathway: a review of its regulation by melatonin and the proteasome.
Vriend J, Reiter RJ. Vriend J, et al. Mol Cell Endocrinol. 2015 Feb 5;401:213-20. doi: 10.1016/j.mce.2014.12.013. Epub 2014 Dec 17. Mol Cell Endocrinol. 2015. PMID: 25528518 Review.
Recent evidence suggests that the antioxidant action of both melatonin and proteasome inhibitors involves the Keap1-ARE (Keap1 antioxidant response element) pathway via the upregulation of Nrf2. Melatonin and proteasome inhibitors suppress the degradat …
Recent evidence suggests that the antioxidant action of both melatonin and proteasome inhibitors involves the Keap1-ARE (Keap1 ant …
Resveratrol inhibits African swine fever virus replication via the Nrf2-mediated reduced glutathione and antioxidative activities.
Liu D, Li LF, Zhai H, Wang T, Lan J, Cao M, Yao M, Wang Y, Li J, Song X, Sun Y, Qiu HJ. Liu D, et al. Emerg Microbes Infect. 2025 Dec;14(1):2469662. doi: 10.1080/22221751.2025.2469662. Epub 2025 Mar 3. Emerg Microbes Infect. 2025. PMID: 39964001 Free PMC article.
Moreover, overexpressing Nrf2 can significantly inhibit ASFV replication. Through high-throughput screening of natural small molecules against ASFV, we identify resveratrol (RES), an Nrf2 activator, as a compound capable of inducing the cellular antiviral respons …
Moreover, overexpressing Nrf2 can significantly inhibit ASFV replication. Through high-throughput screening of natural small molecule …
Iodoacetic acid activates Nrf2-mediated antioxidant response in vitro and in vivo.
Wang S, Zheng W, Liu X, Xue P, Jiang S, Lu D, Zhang Q, He G, Pi J, Andersen ME, Tan H, Qu W. Wang S, et al. Environ Sci Technol. 2014 Nov 18;48(22):13478-88. doi: 10.1021/es502855x. Epub 2014 Nov 4. Environ Sci Technol. 2014. PMID: 25332096
Here we evaluated the toxicity of IAA by examining nuclear factor E2-related factor 2 (Nrf2)-mediated antioxidant response, luciferase antioxidant response element (ARE) activity, and intracellular glutathione (GSH) in HepG2 cells. ...Mor …
Here we evaluated the toxicity of IAA by examining nuclear factor E2-related factor 2 (Nrf2)-mediated antioxidant response …
2,358 results