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Structure-activity relationship of 6-methylidene penems bearing tricyclic heterocycles as broad-spectrum beta-lactamase inhibitors: crystallographic structures show unexpected binding of 1,4-thiazepine intermediates.
Venkatesan AM, Gu Y, Dos Santos O, Abe T, Agarwal A, Yang Y, Petersen PJ, Weiss WJ, Mansour TS, Nukaga M, Hujer AM, Bonomo RA, Knox JR. Venkatesan AM, et al. Among authors: nukaga m. J Med Chem. 2004 Dec 16;47(26):6556-68. doi: 10.1021/jm049680x. J Med Chem. 2004. PMID: 15588091
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