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Extracellular HMGB1 promotes differentiation of nurse-like cells in chronic lymphocytic leukemia.
Jia L, Clear A, Liu FT, Matthews J, Uddin N, McCarthy A, Hoxha E, Durance C, Iqbal S, Gribben JG. Jia L, et al. Blood. 2014 Mar 13;123(11):1709-19. doi: 10.1182/blood-2013-10-529610. Epub 2014 Jan 24. Blood. 2014. PMID: 24464016 Free PMC article.
Chronic lymphocytic leukemia (CLL) is a disease of an accumulation of mature B cells that are highly dependent on the microenvironment for maintenance and expansion. ...CLL cells passively released HMGB1, and the timing and concentrations …
Chronic lymphocytic leukemia (CLL) is a disease of an accumulation of mature B cells that are highly depe …
A Small Molecule Antagonist of CX3CR1 (KAND567) Inhibited the Tumor Growth-Promoting Effect of Monocytes in Chronic Lymphocytic Leukemia (CLL).
Zhong W, Kokhaei P, Mulder TA, Ghaderi A, Moshfegh A, Lundin J, Palma M, Schultz J, Olin T, Österborg A, Mellstedt H, Hojjat-Farsangi M. Zhong W, et al. Cancers (Basel). 2024 Nov 13;16(22):3821. doi: 10.3390/cancers16223821. Cancers (Basel). 2024. PMID: 39594776 Free PMC article.
BACKGROUND/OBJECTIVES: Nurse-like cells (NLCs) derived from monocytes in the tumor microenvironment support the growth of chronic lymphocytic leukemia (CLL) cells. ...CX3CR1 was found on monocytes but not B cells in p …
BACKGROUND/OBJECTIVES: Nurse-like cells (NLCs) derived from monocytes in the tumor microenvironment support the growth …
ZAP-70 expression is associated with enhanced ability to respond to migratory and survival signals in B-cell chronic lymphocytic leukemia (B-CLL).
Richardson SJ, Matthews C, Catherwood MA, Alexander HD, Carey BS, Farrugia J, Gardiner A, Mould S, Oscier D, Copplestone JA, Prentice AG. Richardson SJ, et al. Blood. 2006 May 1;107(9):3584-92. doi: 10.1182/blood-2005-04-1718. Epub 2005 Dec 6. Blood. 2006. PMID: 16332969 Free article.
Molecular markers like IgV(H) mutational status, chromosomal abnormalities, and CD38 and ZAP-70 expression have prognostic value in B-cell chronic lymphocytic leukemia (B-CLL). These may be pathogenetic because of the coincidental express …
Molecular markers like IgV(H) mutational status, chromosomal abnormalities, and CD38 and ZAP-70 expression have prognostic value in B …