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Regulation of epithelial apical junctional complex by Rho family GTPases.
Samarin S, Nusrat A. Samarin S, et al. Front Biosci (Landmark Ed). 2009 Jan 1;14:1129-42. doi: 10.2741/3298. Front Biosci (Landmark Ed). 2009. PMID: 19273120 Review.
The apical junctional complex (AJC), encompassing the tight junction (TJ) and adherens junction (AJ) plays a vital role in regulating epithelial cell differentiation and barrier function of simple epithelia. ...These interactions are tightly controlled by a number o …
The apical junctional complex (AJC), encompassing the tight junction (TJ) and adherens junction (AJ) plays a vital role in regulating …
Rho protein regulates tight junctions and perijunctional actin organization in polarized epithelia.
Nusrat A, Giry M, Turner JR, Colgan SP, Parkos CA, Carnes D, Lemichez E, Boquet P, Madara JL. Nusrat A, et al. Proc Natl Acad Sci U S A. 1995 Nov 7;92(23):10629-33. doi: 10.1073/pnas.92.23.10629. Proc Natl Acad Sci U S A. 1995. PMID: 7479854 Free PMC article.
Tight junctions are membrane microdomains.
Nusrat A, Parkos CA, Verkade P, Foley CS, Liang TW, Innis-Whitehouse W, Eastburn KK, Madara JL. Nusrat A, et al. J Cell Sci. 2000 May;113 ( Pt 10):1771-81. J Cell Sci. 2000. PMID: 10769208
Differential detergent extraction and isopycnic sucrose density gradients were utilized to isolate TJ-enriched membranes from a polarized intestinal epithelial cell line, T84. ...Immunoprecipitation studies revealed coprecipitation of a pool of occludin with caveoli …
Differential detergent extraction and isopycnic sucrose density gradients were utilized to isolate TJ-enriched membranes from a polar …
Human junction adhesion molecule regulates tight junction resealing in epithelia.
Liu Y, Nusrat A, Schnell FJ, Reaves TA, Walsh S, Pochet M, Parkos CA. Liu Y, et al. J Cell Sci. 2000 Jul;113 ( Pt 13):2363-74. J Cell Sci. 2000. PMID: 10852816
Analysis of the primary structure of human JAM, cloned from T84 epithelial cells, predicts a transmembrane protein with an extracellular domain that contains two IgV loops. Monoclonal antibodies generated against the putative extracellular domain were reactive with a
Analysis of the primary structure of human JAM, cloned from T84 epithelial cells, predicts a transmembrane protein with an extracellu …
Modulation of tight junction structure and function by cytokines.
Walsh SV, Hopkins AM, Nusrat A. Walsh SV, et al. Adv Drug Deliv Rev. 2000 Jun 30;41(3):303-13. doi: 10.1016/s0169-409x(00)00048-x. Adv Drug Deliv Rev. 2000. PMID: 10854688 Review.
Disruption of tight junction function drastically alters paracellular permeability and is a hallmark of many pathologic states. ...
Disruption of tight junction function drastically alters paracellular permeability and is a hallmark of many pathologic states. ...
Modulation of tight junction function by G protein-coupled events.
Hopkins AM, Li D, Mrsny RJ, Walsh SV, Nusrat A. Hopkins AM, et al. Adv Drug Deliv Rev. 2000 Jun 30;41(3):329-40. doi: 10.1016/s0169-409x(00)00050-8. Adv Drug Deliv Rev. 2000. PMID: 10854690 Review.
Small G proteins or GTPases comprise a growing family of signal transduction molecules with inducible properties dependent upon reversible interactions with guanine nucleotides. ...
Small G proteins or GTPases comprise a growing family of signal transduction molecules with inducible properties dependent upon rever …
The coiled-coil domain of occludin can act to organize structural and functional elements of the epithelial tight junction.
Nusrat A, Chen JA, Foley CS, Liang TW, Tom J, Cromwell M, Quan C, Mrsny RJ. Nusrat A, et al. J Biol Chem. 2000 Sep 22;275(38):29816-22. doi: 10.1074/jbc.M002450200. J Biol Chem. 2000. PMID: 10887180
A number of other proteins have also been described to localize to the TJ. We have used a novel bait peptide method to investigate potential protein-protein interactions of the putative coiled-coil domain of occludin with some of these other TJ proteins. A 27
A number of other proteins have also been described to localize to the TJ. We have used a novel bait peptide method to investi
Molecular physiology and pathophysiology of tight junctions. IV. Regulation of tight junctions by extracellular stimuli: nutrients, cytokines, and immune cells.
Nusrat A, Turner JR, Madara JL. Nusrat A, et al. Am J Physiol Gastrointest Liver Physiol. 2000 Nov;279(5):G851-7. doi: 10.1152/ajpgi.2000.279.5.G851. Am J Physiol Gastrointest Liver Physiol. 2000. PMID: 11052980 Review.
The epithelial lining of the gastrointestinal tract forms a regulated, selectively permeable barrier between luminal contents and the underlying tissue compartments. ...The TJ is composed of a multiprotein complex that affiliates with the underlying apical actomyosi …
The epithelial lining of the gastrointestinal tract forms a regulated, selectively permeable barrier between luminal contents and the …
Clostridium difficile toxins disrupt epithelial barrier function by altering membrane microdomain localization of tight junction proteins.
Nusrat A, von Eichel-Streiber C, Turner JR, Verkade P, Madara JL, Parkos CA. Nusrat A, et al. Infect Immun. 2001 Mar;69(3):1329-36. doi: 10.1128/IAI.69.3.1329-1336.2001. Infect Immun. 2001. PMID: 11179295 Free PMC article.
A. Bobak, J. Biol. Chem. 273:16021-16026, 1998). We utilized purified reference toxins of C. difficile, TcdA-10463 (TcdA) and TcdB-10463 (TcdB), and a model intestinal epithelial cell line to characterize their influence on tight-junction (TJ) organization and hence
A. Bobak, J. Biol. Chem. 273:16021-16026, 1998). We utilized purified reference toxins of C. difficile, TcdA-10463 (TcdA) and TcdB-10
Neutrophil transepithelial migration: regulation at the apical epithelial surface by Fc-mediated events.
Reaves TA, Colgan SP, Selvaraj P, Pochet MM, Walsh S, Nusrat A, Liang TW, Madara JL, Parkos CA. Reaves TA, et al. Am J Physiol Gastrointest Liver Physiol. 2001 Apr;280(4):G746-54. doi: 10.1152/ajpgi.2001.280.4.G746. Am J Physiol Gastrointest Liver Physiol. 2001. PMID: 11254502
Neutrophil (PMN) transepithelial migration is a major effector of epithelial defense in inflammatory diseases involving mucosal surfaces. ...These results identify a new mechanism for retention of PMN at the apical epithelial surface following transepithelial migrat …
Neutrophil (PMN) transepithelial migration is a major effector of epithelial defense in inflammatory diseases involving mucosal surfa …
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