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Identification of pyrazolopyridazinones as PDEδ inhibitors.
Papke B, Murarka S, Vogel HA, Martín-Gago P, Kovacevic M, Truxius DC, Fansa EK, Ismail S, Zimmermann G, Heinelt K, Schultz-Fademrecht C, Al Saabi A, Baumann M, Nussbaumer P, Wittinghofer A, Waldmann H, Bastiaens PI. Papke B, et al. Among authors: nussbaumer p. Nat Commun. 2016 Apr 20;7:11360. doi: 10.1038/ncomms11360. Nat Commun. 2016. PMID: 27094677 Free PMC article.
Development of Pyridazinone Chemotypes Targeting the PDEδ Prenyl Binding Site.
Murarka S, Martín-Gago P, Schultz-Fademrecht C, Al Saabi A, Baumann M, Fansa EK, Ismail S, Nussbaumer P, Wittinghofer A, Waldmann H. Murarka S, et al. Among authors: nussbaumer p. Chemistry. 2017 May 2;23(25):6083-6093. doi: 10.1002/chem.201603222. Epub 2016 Nov 3. Chemistry. 2017. PMID: 27809361
Insight into Targeting Exon20 Insertion Mutations of the Epidermal Growth Factor Receptor with Wild Type-Sparing Inhibitors.
Lategahn J, Tumbrink HL, Schultz-Fademrecht C, Heimsoeth A, Werr L, Niggenaber J, Keul M, Parmaksiz F, Baumann M, Menninger S, Zent E, Landel I, Weisner J, Jeyakumar K, Heyden L, Russ N, Müller F, Lorenz C, Brägelmann J, Spille I, Grabe T, Müller MP, Heuckmann JM, Klebl BM, Nussbaumer P, Sos ML, Rauh D. Lategahn J, et al. Among authors: nussbaumer p. J Med Chem. 2022 May 12;65(9):6643-6655. doi: 10.1021/acs.jmedchem.1c02080. Epub 2022 Apr 29. J Med Chem. 2022. PMID: 35486541
Dynarrestin, a Novel Inhibitor of Cytoplasmic Dynein.
Höing S, Yeh TY, Baumann M, Martinez NE, Habenberger P, Kremer L, Drexler HCA, Küchler P, Reinhardt P, Choidas A, Zischinsky ML, Zischinsky G, Nandini S, Ledray AP, Ketcham SA, Reinhardt L, Abo-Rady M, Glatza M, King SJ, Nussbaumer P, Ziegler S, Klebl B, Schroer TA, Schöler HR, Waldmann H, Sterneckert J. Höing S, et al. Among authors: nussbaumer p. Cell Chem Biol. 2018 Apr 19;25(4):357-369.e6. doi: 10.1016/j.chembiol.2017.12.014. Epub 2018 Jan 27. Cell Chem Biol. 2018. PMID: 29396292 Free PMC article.
Picomolar, selective, and subtype-specific small-molecule inhibition of TRPC1/4/5 channels.
Rubaiy HN, Ludlow MJ, Henrot M, Gaunt HJ, Miteva K, Cheung SY, Tanahashi Y, Hamzah N, Musialowski KE, Blythe NM, Appleby HL, Bailey MA, McKeown L, Taylor R, Foster R, Waldmann H, Nussbaumer P, Christmann M, Bon RS, Muraki K, Beech DJ. Rubaiy HN, et al. Among authors: nussbaumer p. J Biol Chem. 2017 May 19;292(20):8158-8173. doi: 10.1074/jbc.M116.773556. Epub 2017 Mar 21. J Biol Chem. 2017. PMID: 28325835 Free PMC article.
Identification of Atuveciclib (BAY 1143572), the First Highly Selective, Clinical PTEFb/CDK9 Inhibitor for the Treatment of Cancer.
Lücking U, Scholz A, Lienau P, Siemeister G, Kosemund D, Bohlmann R, Briem H, Terebesi I, Meyer K, Prelle K, Denner K, Bömer U, Schäfer M, Eis K, Valencia R, Ince S, von Nussbaum F, Mumberg D, Ziegelbauer K, Klebl B, Choidas A, Nussbaumer P, Baumann M, Schultz-Fademrecht C, Rühter G, Eickhoff J, Brands M. Lücking U, et al. Among authors: nussbaumer p. ChemMedChem. 2017 Nov 8;12(21):1776-1793. doi: 10.1002/cmdc.201700447. Epub 2017 Oct 16. ChemMedChem. 2017. PMID: 28961375 Free PMC article.
Design, synthesis and biological evaluation of 3,5-disubstituted 2-amino thiophene derivatives as a novel class of antitumor agents.
Romagnoli R, Baraldi PG, Lopez-Cara C, Salvador MK, Preti D, Tabrizi MA, Balzarini J, Nussbaumer P, Bassetto M, Brancale A, Fu XH, Yang-Gao, Li J, Zhang SZ, Hamel E, Bortolozzi R, Basso G, Viola G. Romagnoli R, et al. Among authors: nussbaumer p. Bioorg Med Chem. 2014 Sep 15;22(18):5097-109. doi: 10.1016/j.bmc.2013.12.030. Epub 2013 Dec 24. Bioorg Med Chem. 2014. PMID: 24398384 Free PMC article.
96 results