Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

My NCBI Filters
Text availability
Article attribute
Article type
Publication date

Search Results

194 results
Filters applied: . Clear all Results are displayed in a computed author sort order. Results by year timeline is unavailable
Page 1
Paradoxical decrease in mutant frequencies and chromosomal rearrangements in a transgenic lacZ reporter gene in Ku80 null mice deficient in DNA double strand break repair.
Rockwood LD, Nussenzweig A, Janz S. Rockwood LD, et al. Mutat Res. 2003 Aug 28;529(1-2):51-8. doi: 10.1016/s0027-5107(03)00108-8. Mutat Res. 2003. PMID: 12943919
To examine the impact of NHEJ deficiency on genomic integrity in Ku80 null (Ku-) mice, the chromosomally integrated shuttle vector pUR288, which includes a lacZ reporter gene, was used to measure mutations in vivo. ...The determination of the mutant spectrum in lacZ reveal …
To examine the impact of NHEJ deficiency on genomic integrity in Ku80 null (Ku-) mice, the chromosomally integrated shuttle vector pUR288, w …
Suppression of heat-induced hsp70 expression by the 70-kDa subunit of the human Ku autoantigen.
Li GC, Yang SH, Kim D, Nussenzweig A, Ouyang H, Wei J, Burgman P, Li L. Li GC, et al. Proc Natl Acad Sci U S A. 1995 May 9;92(10):4512-6. doi: 10.1073/pnas.92.10.4512. Proc Natl Acad Sci U S A. 1995. PMID: 7753835 Free PMC article.
These findings support a model in which hsp70 gene expression is controlled by a second regulatory factor in addition to the positive activator HSF1. The Ku autoantigen, or a protein closely related to it, is likely to be involved in the regulation of hsp70 e …
These findings support a model in which hsp70 gene expression is controlled by a second regulatory factor in addition to the p …
Requirement for Ku80 in growth and immunoglobulin V(D)J recombination.
Nussenzweig A, Chen C, da Costa Soares V, Sanchez M, Sokol K, Nussenzweig MC, Li GC. Nussenzweig A, et al. Nature. 1996 Aug 8;382(6591):551-5. doi: 10.1038/382551a0. Nature. 1996. PMID: 8700231
In mutant mice, T and B lymphocyte development is arrested at early progenitor stages and there is a profound deficiency in V(D)J rearrangement. ...The unexpected growth phenotype suggests a new and important link between Ku80 and growth control....
In mutant mice, T and B lymphocyte development is arrested at early progenitor stages and there is a profound deficiency in V(D)J rea …
Cloning and characterization of rat Ku70: involvement of Ku autoantigen in the heat-shock response.
Yang SH, Nussenzweig A, Yang WH, Kim D, Li GC. Yang SH, et al. Radiat Res. 1996 Dec;146(6):603-11. Radiat Res. 1996. PMID: 8955709
To study the role of the Ku autoantigen in the heat-shock response, we have cloned the 70-kDa subunit (the DNA-binding component of Ku) from a rat cDNA library. ...While the formation of the Ku70 and Ku80 complex is important for repair of DNA double-strand breaks our data …
To study the role of the Ku autoantigen in the heat-shock response, we have cloned the 70-kDa subunit (the DNA-binding component of Ku) from …
Ku70 is required for DNA repair but not for T cell antigen receptor gene recombination In vivo.
Ouyang H, Nussenzweig A, Kurimasa A, Soares VC, Li X, Cordon-Cardo C, Li Wh, Cheong N, Nussenzweig M, Iliakis G, Chen DJ, Li GC. Ouyang H, et al. J Exp Med. 1997 Sep 15;186(6):921-9. doi: 10.1084/jem.186.6.921. J Exp Med. 1997. PMID: 9294146 Free PMC article.
Ku is a complex of two proteins, Ku70 and Ku80, and functions as a heterodimer to bind DNA double-strand breaks (DSB) and activate DNA-dependent protein kinase. ...Like Ku80(-/-) mice, Ku70(-/-) mice showed a profound deficiency in DNA DSB repair and were pro …
Ku is a complex of two proteins, Ku70 and Ku80, and functions as a heterodimer to bind DNA double-strand breaks (DSB) and acti …
Hypersensitivity of Ku80-deficient cell lines and mice to DNA damage: the effects of ionizing radiation on growth, survival, and development.
Nussenzweig A, Sokol K, Burgman P, Li L, Li GC. Nussenzweig A, et al. Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):13588-93. doi: 10.1073/pnas.94.25.13588. Proc Natl Acad Sci U S A. 1997. PMID: 9391070 Free PMC article.
We recently have shown that mice deficient for the 86-kDa component (Ku80) of the DNA-dependent protein kinase exhibit growth retardation and a profound deficiency in V(D)J (variable, diversity, and joining) recombination. ...Ku80(-/-) mice display a hypersensitivit …
We recently have shown that mice deficient for the 86-kDa component (Ku80) of the DNA-dependent protein kinase exhibit growth retardation an …
Ku80 is required for immunoglobulin isotype switching.
Casellas R, Nussenzweig A, Wuerffel R, Pelanda R, Reichlin A, Suh H, Qin XF, Besmer E, Kenter A, Rajewsky K, Nussenzweig MC. Casellas R, et al. EMBO J. 1998 Apr 15;17(8):2404-11. doi: 10.1093/emboj/17.8.2404. EMBO J. 1998. PMID: 9545251 Free PMC article.
We have investigated the role of DNA DSB repair in switch recombination in mice that are unable to repair DSBs due to a deficiency in Ku80 (Ku80(-/-)). ...Thus, Ku80 is essential for switch recombination in vivo, suggesting a significant overlap between the molecula …
We have investigated the role of DNA DSB repair in switch recombination in mice that are unable to repair DSBs due to a deficiency in …
DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation.
Difilippantonio MJ, Zhu J, Chen HT, Meffre E, Nussenzweig MC, Max EE, Ried T, Nussenzweig A. Difilippantonio MJ, et al. Nature. 2000 Mar 30;404(6777):510-4. doi: 10.1038/35006670. Nature. 2000. PMID: 10761921 Free PMC article.
Tumours result from a specific set of chromosomal translocations and gene amplifications involving IgH and c-Myc, reminiscent of Burkitt's lymphoma. We conclude that Ku80 is a caretaker gene that maintains the integrity of the genome by a mechanism involving …
Tumours result from a specific set of chromosomal translocations and gene amplifications involving IgH and c-Myc, reminiscent of Burk …
Immature thymocytes undergoing receptor rearrangements are resistant to an Atm-dependent death pathway activated in mature T cells by double-stranded DNA breaks.
Bhandoola A, Dolnick B, Fayad N, Nussenzweig A, Singer A. Bhandoola A, et al. J Exp Med. 2000 Sep 18;192(6):891-7. doi: 10.1084/jem.192.6.891. J Exp Med. 2000. PMID: 10993919 Free PMC article.
Immature CD4(+)CD8(+) thymocytes rearrange their T cell receptor (TCR)-alpha gene locus to generate clonotypic alpha/beta TCR, after which a few cells expressing selectable TCR are signaled to further differentiate into mature T cells. Because of requirements for self-tole …
Immature CD4(+)CD8(+) thymocytes rearrange their T cell receptor (TCR)-alpha gene locus to generate clonotypic alpha/beta TCR, after which …
Response to RAG-mediated VDJ cleavage by NBS1 and gamma-H2AX.
Chen HT, Bhandoola A, Difilippantonio MJ, Zhu J, Brown MJ, Tai X, Rogakou EP, Brotz TM, Bonner WM, Ried T, Nussenzweig A. Chen HT, et al. Science. 2000 Dec 8;290(5498):1962-5. doi: 10.1126/science.290.5498.1962. Science. 2000. PMID: 11110662 Free PMC article.
194 results
Jump to page
Feedback